Shear-dependent attenuation of cellular ROS levels can suppress proinflammatory cytokine injury to human brain microvascular endothelial barrier properties

Journal of Cerebral Blood Flow and Metabolism

Volumn 35, Issue 10, 2015, Pages 1648-1656

  Rochfort, Keith D ^a   Collins, Laura E ^a   McLoughlin, Alisha ^a   Cummins, Philip M ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

blood brain barrier; cerebrovascular disease; endothelium; free radicals

Indexed keywords

CLAUDIN 5; CYTOKINE; INTERLEUKIN 6; OCCLUDIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TUMOR NECROSIS FACTOR ALPHA; VASCULAR ENDOTHELIAL CADHERIN;

ARTICLE; BRAIN CAPILLARY ENDOTHELIAL CELL; BRAIN INJURY; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SHEAR STRESS; VASCULAR ENDOTHELIUM; BIOSYNTHESIS; BLOOD BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CELL JUNCTION; DOSE RESPONSE; DRUG EFFECTS; MECHANICAL STRESS; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE;

BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; INTERCELLULAR JUNCTIONS; INTERLEUKIN-6; NADPH OXIDASE; PRIMARY CELL CULTURE; REACTIVE OXYGEN SPECIES; STRESS, MECHANICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84942982903     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2015.102     Document Type: Article

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