메뉴 건너뛰기




Volumn 10, Issue 8, 2015, Pages

Characterization of Sin1 isoforms reveals an mTOR-dependent and independent function of sin1γ

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; SIN1 BETA PROTEIN; SIN1 PROTEIN; UNCLASSIFIED DRUG; MAPKAP1 PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2; TUBULIN;

EID: 84942944786     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135017     Document Type: Article
Times cited : (22)

References (26)
  • 1
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • PMID: 22500797
    • Laplante M, Sabatini DM (2012) mTOR signaling in growth control and disease. Cell 149: 274-293. doi:10.1016/j.cell.2012.03.017 PMID: 22500797
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 2
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • PMID:20965424
    • Sengupta S, Peterson TR, Sabatini DM (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40: 310-322. doi:10.1016/j.molcel.2010.09.026 PMID:20965424
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 3
    • 81855169682 scopus 로고    scopus 로고
    • Mammalian TOR signaling to the AGC kinases
    • PMID: 21981278
    • Su B, Jacinto E (2011) Mammalian TOR signaling to the AGC kinases. Crit Rev Biochem Mol Biol 46: 527-547. doi:10.3109/10409238.2011.618113 PMID: 21981278
    • (2011) Crit Rev Biochem Mol Biol , vol.46 , pp. 527-547
    • Su, B.1    Jacinto, E.2
  • 4
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • PMID: 21157483
    • Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35. doi:10.1038/nrm3025 PMID: 21157483
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 5
    • 39749100492 scopus 로고    scopus 로고
    • TOR regulation of AGC kinases in yeast and mammals
    • PMID: 18215152
    • Jacinto E, Lorberg A (2008) TOR regulation of AGC kinases in yeast and mammals. Biochem J 410: 19-37. doi:10.1042/BJ20071518 PMID: 18215152
    • (2008) Biochem J , vol.410 , pp. 19-37
    • Jacinto, E.1    Lorberg, A.2
  • 6
    • 33750068623 scopus 로고    scopus 로고
    • MTOR, translation initiation and cancer
    • PMID: 17041626
    • Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N (2006) mTOR, translation initiation and cancer. Oncogene 25: 6416-6422. PMID: 17041626
    • (2006) Oncogene , vol.25 , pp. 6416-6422
    • Mamane, Y.1    Petroulakis, E.2    LeBacquer, O.3    Sonenberg, N.4
  • 7
    • 47949125486 scopus 로고    scopus 로고
    • The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
    • PMID: 18566586
    • Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C et al. (2008) The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 27: 1932-1943. doi: 10.1038/emboj.2008.120 PMID: 18566586
    • (2008) EMBO J , vol.27 , pp. 1932-1943
    • Facchinetti, V.1    Ouyang, W.2    Wei, H.3    Soto, N.4    Lazorchak, A.5    Gould, C.6
  • 8
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • PMID: 16962653
    • Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY et al. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127: 125-137. PMID: 16962653
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6
  • 9
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • PMID: 15467718
    • Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 6: 1122-1128. PMID: 15467718
    • (2004) Nat Cell Biol , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6
  • 10
    • 33751079895 scopus 로고    scopus 로고
    • Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
    • PMID: 17043309
    • Yang Q, Inoki K, Ikenoue T, Guan KL (2006) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20: 2820-2832. PMID: 17043309
    • (2006) Genes Dev , vol.20 , pp. 2820-2832
    • Yang, Q.1    Inoki, K.2    Ikenoue, T.3    Guan, K.L.4
  • 11
    • 21744434031 scopus 로고    scopus 로고
    • Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation
    • PMID: 15988011
    • Cheng J, Zhang D, Kim K, Zhao Y, Su B (2005) Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. Mol Cell Biol 25: 5955-5964. PMID: 15988011
    • (2005) Mol Cell Biol , vol.25 , pp. 5955-5964
    • Cheng, J.1    Zhang, D.2    Kim, K.3    Zhao, Y.4    Su, B.5
  • 12
    • 34147097962 scopus 로고    scopus 로고
    • Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling
    • PMID: 17303383
    • Schroder WA, Buck M, Cloonan N, Hancock JF, Suhrbier A, Sculley T et al. (2007) Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. Cell Signal 19: 1279-1289. PMID: 17303383
    • (2007) Cell Signal , vol.19 , pp. 1279-1289
    • Schroder, W.A.1    Buck, M.2    Cloonan, N.3    Hancock, J.F.4    Suhrbier, A.5    Sculley, T.6
  • 13
    • 0033517116 scopus 로고    scopus 로고
    • Sin1: An evolutionarily conserved component of the eukaryotic SAPK pathway
    • PMID: 10428959
    • Wilkinson MG, Pino TS, Tournier S, Buck V, Martin H, Christiansen J et al. (1999) Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway. EMBO J 18: 4210-4221. PMID: 10428959
    • (1999) EMBO J , vol.18 , pp. 4210-4221
    • Wilkinson, M.G.1    Pino, T.S.2    Tournier, S.3    Buck, V.4    Martin, H.5    Christiansen, J.6
  • 14
    • 0025771976 scopus 로고
    • Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae
    • PMID: 1849280
    • Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M. (1991) Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88: 2913-2917. PMID: 1849280
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2913-2917
    • Colicelli, J.1    Nicolette, C.2    Birchmeier, C.3    Rodgers, L.4    Riggs, M.5    Wigler, M.6
  • 15
    • 80053286420 scopus 로고    scopus 로고
    • MTORC2 targets AGC kinases through Sin1-dependent recruitment
    • PMID: 21806543
    • Cameron AJ, Linch MD, Saurin AT, Escribano C, Parker PJ (2011) mTORC2 targets AGC kinases through Sin1-dependent recruitment. Biochem J 439: 287-297. doi: 10.1042/BJ20110678 PMID: 21806543
    • (2011) Biochem J , vol.439 , pp. 287-297
    • Cameron, A.J.1    Linch, M.D.2    Saurin, A.T.3    Escribano, C.4    Parker, P.J.5
  • 16
    • 13844294205 scopus 로고    scopus 로고
    • The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins
    • PMID: 15722200
    • Schroder W, Bushell G, Sculley T (2005) The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins. Cell Signal 17: 761-767. PMID: 15722200
    • (2005) Cell Signal , vol.17 , pp. 761-767
    • Schroder, W.1    Bushell, G.2    Sculley, T.3
  • 17
    • 4444377577 scopus 로고    scopus 로고
    • Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene
    • PMID: 15363842
    • Schroder W, Cloonan N, Bushell G, Sculley T (2004) Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene. Gene 339: 17-23. PMID: 15363842
    • (2004) Gene , vol.339 , pp. 17-23
    • Schroder, W.1    Cloonan, N.2    Bushell, G.3    Sculley, T.4
  • 18
    • 33748471980 scopus 로고    scopus 로고
    • MSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
    • PMID: 16919458
    • Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA et al. (2006) mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol 16: 1865-1870. PMID: 16919458
    • (2006) Curr Biol , vol.16 , pp. 1865-1870
    • Frias, M.A.1    Thoreen, C.C.2    Jaffe, J.D.3    Schroder, W.4    Sculley, T.5    Carr, S.A.6
  • 19
    • 42049121223 scopus 로고    scopus 로고
    • SSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1
    • PMID: 18331714
    • Wang X, Yang Y, Duan Q, Jiang N, Huang Y, Darzynkiewicz Z et al. (2008) sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Dev Cell 14: 331-341. doi:10.1016/j.devcel.2007.12.007 PMID: 18331714
    • (2008) Dev Cell , vol.14 , pp. 331-341
    • Wang, X.1    Yang, Y.2    Duan, Q.3    Jiang, N.4    Huang, Y.5    Darzynkiewicz, Z.6
  • 20
    • 78649957196 scopus 로고    scopus 로고
    • Mechanisms of centrosome separation and bipolar spindle assembly
    • PMID: 21145497
    • Tanenbaum ME, Medema RH (2010) Mechanisms of centrosome separation and bipolar spindle assembly. Dev Cell 19: 797-806. doi:10.1016/j.devcel.2010.11.011 PMID: 21145497
    • (2010) Dev Cell , vol.19 , pp. 797-806
    • Tanenbaum, M.E.1    Medema, R.H.2
  • 21
    • 29144530336 scopus 로고    scopus 로고
    • Mutational analyses reveal a novel function of the nucleotide-binding domain of gamma-tubulin in the regulation of basal body biogenesis
    • PMID: 16344310
    • Shang Y, Tsao CC, Gorovsky MA (2005) Mutational analyses reveal a novel function of the nucleotide-binding domain of gamma-tubulin in the regulation of basal body biogenesis. J Cell Biol 171: 1035-1044. PMID: 16344310
    • (2005) J Cell Biol , vol.171 , pp. 1035-1044
    • Shang, Y.1    Tsao, C.C.2    Gorovsky, M.A.3
  • 22
    • 0035899865 scopus 로고    scopus 로고
    • Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles
    • PMID: 11676918
    • Deane JA, Cole DG, Seeley ES, Diener DR, Rosenbaum JL (2001) Localization of intraflagellar transport protein IFT52 identifies basal body transitional fibers as the docking site for IFT particles. Curr Biol 11: 1586-1590. PMID: 11676918
    • (2001) Curr Biol , vol.11 , pp. 1586-1590
    • Deane, J.A.1    Cole, D.G.2    Seeley, E.S.3    Diener, D.R.4    Rosenbaum, J.L.5
  • 23
    • 35648985644 scopus 로고    scopus 로고
    • Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
    • PMID: 17906624
    • Gerdes JM, Liu Y, Zaghloul NA, Leitch CC, Lawson SS, Kato M et al. (2007) Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet 39: 1350-1360. PMID: 17906624
    • (2007) Nat Genet , vol.39 , pp. 1350-1360
    • Gerdes, J.M.1    Liu, Y.2    Zaghloul, N.A.3    Leitch, C.C.4    Lawson, S.S.5    Kato, M.6
  • 24
    • 84863116083 scopus 로고    scopus 로고
    • Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation
    • PMID: 22308353
    • Yuan S1, Li J, Diener DR, Choma MA, Rosenbaum JL, Sun Z. (2012) Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proc Natl Acad Sci U S A 109: 2021-2026 doi: 10.1073/pnas.1112834109 PMID: 22308353
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 2021-2026
    • Yuan, S.L.1    Li, J.2    Diener, D.R.3    Choma, M.A.4    Rosenbaum, J.L.5    Sun, Z.6
  • 25
    • 80052863830 scopus 로고    scopus 로고
    • Endoplasmic reticulum is a main localization site of mTORC2
    • PMID:21867682
    • Boulbes DR, Shaiken T, Sarbassov dos D (2011) Endoplasmic reticulum is a main localization site of mTORC2. Biochem Biophys Res Commun 413: 46-52. doi: 10.1016/j.bbrc.2011.08.034 PMID:21867682
    • (2011) Biochem Biophys Res Commun , vol.413 , pp. 46-52
    • Boulbes, D.R.1    Shaiken, T.2    Sarbassov Dos, D.3
  • 26
    • 84884729110 scopus 로고    scopus 로고
    • The Bar-det-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the TOR complex
    • PMID: 23727834
    • Cardenas-Rodriguez M, Irigoín F, Osborn DP, Gascue C, Katsanis N, Beales PL et al.(2013) The Bar-det-Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the TOR complex. Hum Mol Genet 22: 4031-42. doi: 10.1093/hmg/ddt253 PMID: 23727834
    • (2013) Hum Mol Genet , vol.22 , pp. 4031-4042
    • Cardenas-Rodriguez, M.1    Irigoín, F.2    Osborn, D.P.3    Gascue, C.4    Katsanis, N.5    Beales, P.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.