Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes

Clinical Science

Volumn 129, Issue 7, 2015, Pages 561-574

  Tocchetti, Carlo G ^a,b   Stanley, Brian A ^a   Sivakumaran, Vidhya ^a   Bedja, Djahida ^a,c   O'Rourke, Brian ^a   Paolocci, Nazareno ^a   Cortassa, Sonia ^a   Aon, Miguel A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c MACQUARIE UNIVERSITY   (Australia)

Author keywords

Adrenergic stimulation; Calcium transient; Contractility; Diabetes; Energetic transitions; Glutathione; Hyperglycaemia; Redox balance

Indexed keywords

ADENOSINE DIPHOSPHATE; CATALASE; CYTOCHROME C OXIDASE; FATTY ACID; GLUCOSE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; INSULIN; INSULIN GLARGINE; ISOPRENALINE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; OXIDIZING AGENT; OXYGEN; PALMITIC ACID; PEROXIREDOXIN; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE; THIOREDOXIN 1; THIOREDOXIN 2; THIOREDOXIN REDUCTASE 1; THIOREDOXIN REDUCTASE 2; BETA ADRENERGIC RECEPTOR; CALCIUM; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; CELL ISOLATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG INFUSION; ENERGY RESOURCE; GUINEA PIG; HEART CONTRACTION; HEART FUNCTION; HEART MUSCLE CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SENSITIVITY; INSULIN TREATMENT; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MYOCARDIAL DISEASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REDOX STRESS; RESPIRATORY CHAIN; SHAM PROCEDURE; ANIMAL; CHEMISTRY; CYTOLOGY; DISEASE MODEL; FLUORESCENCE MICROSCOPY; GLUCOSE BLOOD LEVEL; HEART MITOCHONDRION; MALE; METABOLISM; MUSCLE CELL; MUSCLE CONTRACTION; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; SARCOMERE;

ANIMALS; BLOOD GLUCOSE; CALCIUM; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; FATTY ACIDS; GUINEA PIGS; HYDROGEN PEROXIDE; INSULIN; MALE; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIA, HEART; MUSCLE CELLS; MUSCLE CONTRACTION; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; OXYGEN; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RECEPTORS, ADRENERGIC, BETA; SARCOMERES;

EID: 84942932965     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150204     Document Type: Article

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