Comparative analysis of two gene-targeting approaches challenges the tumor-suppressive role of the protein kinase MK5/PRAK

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Ronkina, Natalia ^a   Johansen, Claus ^b   Bohlmann, Lisa ^a   Lafera, Juri ^a   Menon, Manoj B ^a   Tiedje, Christopher ^a   Laaß, Kathrin ^a   Turk, Benjamin E ^c   Iversen, Lars ^b   Kotlyarov, Alexey ^a   Gaestel, Matthias ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 7; PROTEIN KINASE; PROTEIN PRAK; UNCLASSIFIED DRUG; MAP-KINASE-ACTIVATED KINASE 5; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CATALYSIS; CELL CULTURE; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME STABILITY; EXON; EXON SKIPPING; GENE SILENCING; GENE TARGETING; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; SKIN CARCINOMA; ANIMAL; C57BL MOUSE; GENE DELETION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; PATHOLOGY; PROCEDURES; PROTEIN STABILITY; RNA INTERFERENCE; SKIN; SKIN TUMOR;

ANIMALS; CELLS, CULTURED; EXONS; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE, INBRED C57BL; PROTEIN STABILITY; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SKIN; SKIN NEOPLASMS; TUMOR SUPPRESSOR PROTEINS;

EID: 84942890681     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136138     Document Type: Article

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