Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 39, 2015, Pages 12151-12156

  Moreau, Hélène D ^a,b,c   Lemaître, Fabrice ^a,b   Garrod, Kym R ^a,b   Garcia, Zacarias ^a,b   Lennon Duménil, Ana Maria ^d   Bousso, Philippe ^a,b   Cahalan, Michael D ^e  

^a INSTITUT PASTEUR   (France)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d PSL RESEARCH UNIVERSITY   (France)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Kinapse; Migration; Synapse; T cell

Indexed keywords

ACTIN RELATED PROTEIN 2-3 COMPLEX; T LYMPHOCYTE RECEPTOR; CALCIUM; T LYMPHOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; DECELERATION; EXPLORATORY BEHAVIOR; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SYNAPSE; T LYMPHOCYTE; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; CELL MOTION; CELLULAR IMMUNITY; FLOW CYTOMETRY; IMMUNOLOGICAL SYNAPSE; IMMUNOLOGY; METABOLISM; NONPARAMETRIC TEST; TUMOR MICROENVIRONMENT;

ACTIN-RELATED PROTEIN 2-3 COMPLEX; ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CALCIUM; CELL MOVEMENT; CELLULAR MICROENVIRONMENT; FLOW CYTOMETRY; IMMUNITY, CELLULAR; IMMUNOLOGICAL SYNAPSES; MICE; MICE, INBRED C57BL; STATISTICS, NONPARAMETRIC; T-LYMPHOCYTES;

EID: 84942863487     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1506654112     Document Type: Article

References (27)

1. Miller MJ, Wei SH, Parker I, Cahalan M.D. (2002) Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296(5574):1869-1873.
2. Bajénoff M, et al (2006) Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25(6):989-1001.
3. Dustin ML (2008) T-cell activation through immunological synapses and kinapses. Immunol Rev 221:77-89.
4. Moreau HD, Bousso P. (2014) Visualizing how T cells collect activation signals in vivo. Curr Opin Immunol 26:56-62.
5. Bhakta NR, Oh DY, Lewis R.S. (2005) Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environment. Nat Immunol 6(2):143-151.
6. Skokos D, et al (2007) Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat Immunol 8(8):835-844.
7. Waite JC, et al (2013) Interference with Ca(2+) release activated Ca(2+) (CRAC) channel function delays T-cell arrest in vivo. Eur J Immunol 43(12):3343-3354.
8. Mempel TR, Henrickson SE, Von Andrian UH (2004) T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427(6970):154-159.
9. Miller MJ, Safrina O, Parker I, Cahalan M.D. (2004) Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes. J Exp Med 200(7):847-856.
10. Hugues S, et al (2004) Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity. Nat Immunol 5(12):1235-1242.
11. Moreau HD, et al (2012) Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo. Immunity 37(2):351-363.
12. Shulman Z, et al (2014) Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science 345(6200):1058-1062.
13. Gunzer M, et al (2000) Antigen presentation in extracellular matrix: Interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 13(3): 323-332.
14. Friedman RS, Beemiller P, Sorensen CM, Jacobelli J, Krummel M.F. (2010) Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med 207(12):2733-2749.
15. Faure-André G, et al. (2008) Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain. Science 322(5908):1705-1710.
16. Jacobelli J, et al (2010) Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol 11(10): 953-961.
17. Zehn D, Lee SY, Bevan M.J. (2009) Complete but curtailed T-cell response to very low-affinity antigen. Nature 458(7235):211-214.
18. Negulescu PA, Krasieva TB, Khan A, Kerschbaum HH, Cahalan M.D. (1996) Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 4(5):421-430.
19. Ritter AT, Angus KL, Griffiths G.M. (2013) The role of the cytoskeleton at the immunological synapse. Immunol Rev 256(1):107-117.
20. Sims TN, et al (2007) Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell 129(4):773-785.
21. Kumari S, et al (2015) Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway. Elife 4:e04953.
22. Jacobelli J, Bennett FC, Pandurangi P, Tooley AJ, Krummel M.F. (2009) Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration. J Immunol 182(4):2041-2050.
23. Liu YJ, et al (2015) Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cells. Cell 160(4):659-672.
24. Gérard A, et al (2014) Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g. Cell 158(3):492-505.
25. Celli S, Lemaître F, Bousso P. (2007) Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation. Immunity 27(4):625-634.
26. Piel M, Meyer P, Khodjakov A, Rieder CL, Bornens M. (2000) The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells. J Cell Biol 149(2):317-330.
27. Azar GA, Lemaître F, Robey EA, Bousso P. (2010) Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes. Proc Natl Acad Sci USA 107(8): 3675-3680.