A mutation in transmembrane domain 7 (TM7) of excitatory amino acid transporters disrupts the substrate-dependent gating of the intrinsic anion conductance and drives the channel into a constitutively open state

Journal of Biological Chemistry

Volumn 290, Issue 38, 2015, Pages 22977-22990

  Torres Salazar, Delany ^a   Jiang, Jie ^b,c   Divito, Christopher B ^b   Garcia Olivares, Jennie ^a   Amara, Susan G ^a,b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; DIGITAL STORAGE; IONS; MAMMALS;

CENTRAL NERVOUS SYSTEMS; EXCITATORY AMINO ACIDS; EXTRACELLULAR SPACE; NEGATIVELY CHARGED; SATURATING CONCENTRATION; STRUCTURAL COUPLING; SUBSTRATE INDEPENDENTS; TRANS-MEMBRANE DOMAINS;

SUBSTRATES;

EXCITATORY AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; EXCITATORY AMINO ACID TRANSPORTER 4; GLUTAMIC ACID; MEMBRANE PROTEIN; SODIUM; TRANSMEMBRANE DOMAIN 7; UNCLASSIFIED DRUG; RECOMBINANT PROTEIN; SLC1A3 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; BIOTINYLATION; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ION CONDUCTANCE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN TRANSPORT; VOLTAGE CLAMP TECHNIQUE; ANIMAL; GENE EXPRESSION; GENETICS; HUMAN; ION TRANSPORT; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; XENOPUS LAEVIS;

AMINO ACID SUBSTITUTION; ANIMALS; EXCITATORY AMINO ACID TRANSPORTER 1; GENE EXPRESSION; HUMANS; ION CHANNEL GATING; ION TRANSPORT; MUTATION, MISSENSE; OOCYTES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 84942860897     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.660860     Document Type: Article

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