Noise analysis to study unitary properties of transporter-associated ion channels

Channels

Volumn 5, Issue 6, 2011, Pages 468-474

  Machtens, Jan Philipp ^a   Fahlke, Christoph ^a,b   Kovermann, Peter ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

EAAT4; Glutamate; Membrane biophysics; Neurotransmitter transport; Noise analysis

Indexed keywords

ANION CHANNEL; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMIC ACID; NITRATE;

ANALYSIS; ARTICLE; MACROSCOPIC CURRENT RECORDING; NOISE ANALYSIS; RECORDING;

EID: 84455210220     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.5.6.17453     Document Type: Article

References (30)

1. Anderson CR, Stevens CF. Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction. J Physiol (London) 1973; 235:655-91.
2. DeFelice LJ. Introduction to membrane noise, New York, NY: Plenum Press.
3. Sigworth FJ. The variance of sodium current fluctuations at the node of ranvier. J Physiol (London) 1980; 307:97-129. (Pubitemid 11253739)
4. Fischer M, Janssen AG, Fahlke Ch. Barttin activates ClC-K channel function by modulating gating. J Am Soc Nephrol 2010; 21:1281-9.
5. Torres GE, Amara SG. Glutamate and monoamine transporters: new visions of form and function. Curr Opin Neurobiol 2007; 17:304-12. (Pubitemid 46880333)
6. Kanner BI. Structure and function of sodium-coupled GABA and glutamate transporters. J Membr Biol 2006; 213:89-100. (Pubitemid 46626128)
7. Grewer C, et al. Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia. IUBMB Life 2008; 60:609-19.
8. Levy LM, Warr O, Attwell D. Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake. J Neurosci 1998; 18:9620-8. (Pubitemid 28543743)
9. Zerangue N, Kavanaugh MP. Flux coupling in a neuronal glutamate transporter. Nature 1996; 383:634-7. (Pubitemid 26347587)
10. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 1995; 375:599-603.
11. Wadiche JI, Kavanaugh MP. Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel. J Neurosci 1998; 18:7650-61. (Pubitemid 28441007)
12. Melzer N, Biela A, Fahlke Ch. Glutamate modifies ion conduction and voltage-dependent gating of excitatory amino acid transporter-associated anion channels. J Biol Chem 2003; 278:50112-9. (Pubitemid 37548848)
13. Melzer N, Torres-Salazar D, Fahlke Ch. A dynamic switch between inhibitory and excitatory currents in a neuronal glutamate transporter. Proc Natl Acad Sci USA 2005; 102:19214-8. (Pubitemid 43049592)
14. Grewer C, Watzke N, Wiessner M, Rauen T. Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds. Proc Natl Acad Sci USA 2000; 97:9706-11. (Pubitemid 30650840)
15. Grewer C, Rauen T. Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling. J Membr Biol 2005; 203:1-20. (Pubitemid 40576957)
16. Leinenweber A, Machtens JP, Begemann B, Fahlke Ch. Regulation of glial glutamate transporters by C-terminal domains. J Biol Chem 2011; 286:1927-37.
17. Bergles DE, Tzingounis AV, Jahr CE. Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters. J Neurosci 2002; 22:10153-62. (Pubitemid 35416854)
18. Otis TS, Kavanaugh MP. Isolation of current components and partial reaction cycles in the glial glutamate transporter EAAT2. J Neurosci 2000; 20:2749-57. (Pubitemid 30220298)
19. Watzke N, Bamberg E, Grewer C. Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1. J Gen Physiol 2001; 117:547-62. (Pubitemid 32552263)
20. Torres-Salazar D, Fahlke Ch. Neuronal glutamate transporters vary in substrate transport rate but not in unitary anion channel conductance. J Biol Chem 2007; 282:34719-26. (Pubitemid 350232448)
21. Mim C, Balani P, Rauen T, Grewer C. The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism. J Gen Physiol 2005; 126:571-89. (Pubitemid 41713738)
22. Machtens JP, Kovermann P, Fahlke Ch. Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4. J Biol Chem 2011; 286:23780-8.
23. Kovermann P, Machtens JP, Ewers D, Fahlke Ch. A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4). J Biol Chem 2010; 285:23676-86.
24. DeFelice LJ, Galli A. Fluctuation analysis of norepinephrine and serotonin transporter currents. Meth Enzym 1998; 296:578-93. (Pubitemid 28455047)
25. Reyes N, Ginter C, Boudker O. Transport mechanism of a bacterial homologue of glutamate transporters. Nature 2009; 462:880-5.
26. Gillespie DT. Exact stochastic simulation of coupled chemical reactions. J Phys Chem 1977; 81:2340-61.
27. Clay JR, DeFelice LJ. Relationship between membrane excitability and single channel open-close kinetics. Biophys J 1983; 42:151-7. (Pubitemid 13064265)
28. Neher E, Stevens CF. Conductance fluctuations and ionic pores in membranes. Annu Rev Biophys Bioeng 1977; 6:345-81.
29. Ks channels and channels formed with two minK mutants that cause long QT syndrome. J Gen Physiol 1998; 112:651-63.
30. Garcia-Olivares J, et al. Gating of human ClC-2 chloride channels and regulation by carboxy-terminal domains. J Physiol (London) 2008; 586:5325-36.