A conserved aspartate determines pore properties of anion channels associated with Excitatory Amino Acid Transporter 4 (EAAT4)

Journal of Biological Chemistry

Volumn 285, Issue 31, 2010, Pages 23676-23686

  Kovermann, Peter ^a,b   Machtens, Jan Philipp ^a,b   Ewers, David ^a,b   Fahlke, Christoph ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Zentrum für Systemische Neurowissenschaften   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANION CHANNELS; ASPARTATES; ASPARTIC ACIDS; CHANNEL GATING; CONCENTRATION-DEPENDENT; EXCITATORY AMINO ACIDS; GLUTAMATE TRANSPORTERS; HETEROLOGOUS EXPRESSION; INTRACELLULAR LOOP; ISOFORMS; L-GLUTAMATE; MAMMALIAN CELLS; NOISE ANALYSIS; OPEN CHANNELS; PORE PROPERTY; POSITIVE POTENTIAL; RELATIVE ANIONS; RELAXATION CONSTANTS; TRANS-MEMBRANE DOMAINS; TRANSPORT SUBSTRATES; VOLTAGE DEPENDENCE; WHOLE CELL PATCH CLAMP; WILD TYPES;

ACTIVATION ANALYSIS; AMINO ACIDS; MAMMALS; ORGANIC ACIDS; PROBABILITY; SUBSTRATES;

NEGATIVE IONS;

ALANINE; ANION CHANNEL; ASPARTIC ACID; EXCITATORY AMINO ACID TRANSPORTER 4; GLUTAMIC ACID;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; GENE MUTATION; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; ION CONDUCTANCE; ION PERMEABILITY; MEMBRANE DEPOLARIZATION; PRIORITY JOURNAL; WILD TYPE;

ANIONS; ASPARTIC ACID; BIOPHYSICS; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID TRANSPORTER 4; GLUTAMIC ACID; HUMANS; KINETICS; NEUROTRANSMITTER AGENTS; PATCH-CLAMP TECHNIQUES; PERMEABILITY; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY;

MAMMALIA;

EID: 77954929051     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.126557     Document Type: Article

References (38)

1. Fairman, W. A., and Amara, S. G. (1999) Am. J. Physiol. 277, F481-F486
2. Wadiche, J. I., Amara, S. G., and Kavanaugh, M. P. (1995) Neuron 15, 721-728
3. Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaugh, M. P., and Amara, S. G. (1995) Nature 375, 599-603
4. Watzke, N., and Grewer, C. (2001) FEBS Lett. 503, 121-125
5. Melzer, N., Biela, A., and Fahlke, Ch. (2003) J. Biol. Chem. 278, 50112-50119
6. Amara, S. G., and Fontana, A. C. (2002) Neurochem. Int. 41, 313-318
7. Melzer, N., Torres-Salazar, D., and Fahlke, Ch. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 19214-19218
8. Gouaux, E., and Mackinnon, R. (2005) Science 310, 1461-1465
9. Yernool, D., Boudker, O., Jin, Y., and Gouaux, E. (2004) Nature 431, 811-818
10. Boudker, O., Ryan, R. M., Yernool, D., Shimamoto, K., and Gouaux, E. (2007) Nature 445, 387-393
11. Reyes, N., Ginter, C., and Boudker, O. (2009) Nature 462, 880-885
12. Tao, Z., and Grewer, C. (2007) J. Gen. Physiol. 129, 331-344
13. Tao, Z., Zhang, Z., and Grewer, C. (2006) J. Biol. Chem. 281, 10263-10272
14. Larsson, H. P., Tzingounis, A. V., Koch, H. P., and Kavanaugh, M. P. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 3951-3956
15. Koch, H. P., and Larsson, H. P. (2005) J. Neurosci. 25, 1730-1736
16. Yang, N., and Horn, R. (1995) Neuron 15, 213-218
17. Schoppa, N. E., McCormack, K., Tanouye, M. A., and Sigworth, F. J. (1992) Science 255, 1712-1715
18. Fahlke, Ch., Beck, C. L., and George, A. L., Jr. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 2729-2734
19. Ryan, R. M., Mitrovic, A. D., and Vandenberg, R. J. (2004) J. Biol. Chem. 279, 20742-20751
20. Torres-Salazar, D., and Fahlke, Ch. (2006) J. Neurosci. 26, 7513-7522
21. Mim, C., Balani, P., Rauen, T., and Grewer, C. (2005) J. Gen. Physiol. 126, 571-589
22. Torres-Salazar, D., and Fahlke, Ch. (2007) J. Biol. Chem. 282, 34719-34726
23. Sigworth, F. J., and Zhou, J. (1992) Methods Enzymol. 207, 746-762
24. Sesti, F., and Goldstein, S. A. (1998) J. Gen. Physiol. 112, 651-663
25. Bergles, D. E., Tzingounis, A. V., and Jahr, C. E. (2002) J. Neurosci. 22, 10153-10162
26. Arnold, K., Bordoli, L., Kopp, J., and Schwede, T. (2006) Bioinformatics 22, 195-201
27. DeFelice, L. J. (1981) in Introduction to Membrane Noise (DeFelice, L. J., ed) Plenum Press, New York
28. Garcia-Olivares, J., Alekov, A., Boroumand, M. R., Begemann, B., Hidalgo, P., and Fahlke, Ch. (2008) J. Physiol. 586, 5325-5336
29. Fahlke, Ch., Yu, H. T., Beck, C. L., Rhodes, T. H., and George, A. L., Jr. (1997) Nature 390, 529-532
30. Grewer, C., Gameiro, A., Zhang, Z., Tao, Z., Braams, S., and Rauen, T. (2008) IUBMB Life 60, 609-619
31. Shachnai, L., Shimamoto, K., and Kanner, B. I. (2005) Neuropharmacology 49, 862-871
32. Huang, S., and Vandenberg, R. J. (2007) Biochemistry 46, 9685-9692
33. Ryan, R. M., and Mindell, J. A. (2007) Nat. Struct. Mol. Biol. 14, 365-371
34. Vandenberg, R. J., Huang, S., and Ryan, R. M. (2008) Channels 2, 51-58
35. Swenson, R. P., Jr., and Armstrong, C. M. (1981) Nature 291, 427-429
36. Watzke, N., Bamberg, E., and Grewer, C. (2001) J. Gen. Physiol. 117, 547-562
37. Raunser, S., Appel, M., Ganea, C., Geldmacher-Kaufer, U., Fendler, K., and Kühlbrandt, W. (2006) Biochemistry 45, 12796-12805
38. Bouvier, M., Szatkowski, M., Amato, A., and Attwell, D. (1992) Nature 360, 471-474