Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 20, 2015, Pages 4437-4440

  Hendriks, Christine M M ^a   Penning, Trevor M ^b   Zang, Tianzhu ^b   Wiemuth, Dominik ^c   Gründer, Stefan ^c   Sanhueza, Italo A ^a   Schoenebeck, Franziska ^a   Bolm, Carsten ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

AKR1C3 inhibitor; Bile acid sensitive ion channel; Computational conformational analyses; Flufenamic acid; Ion channel modulator; Pentafluorosulfanyl group

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; FLUFENAMIC ACID; FLUOROSULFONIC ACID; ION CHANNEL; LACTOYLGLUTATHIONE LYASE; 15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; AKR1C3 PROTEIN, HUMAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENZYME INHIBITOR; THIOL DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CASTRATION RESISTANT PROSTATE CANCER; CATALYSIS; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

3-HYDROXYSTEROID DEHYDROGENASES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLUFENAMIC ACID; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 84942837633     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.09.012     Document Type: Article

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