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For two representative examples from the patent literature, see:
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84873834959
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For advanced syntheses of N-cyano sulfoximines, see:
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For advanced syntheses of N-cyano sulfoximines, see:
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For a related study demonstrating COX inhibition and estrogen receptor binding of sulfoximines with a triaryl olefin core, see
-
For a related study demonstrating COX inhibition and estrogen receptor binding of sulfoximines with a triaryl olefin core, see: X. Y. Chen, S. J. Park, H. Buschmann, M. DeRosa, C. Bolm, Bioorg. Med. Chem. Lett. 2012, 22, 4307.
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19
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85099490941
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50 values are given in the Supporting Information.
-
50 values are given in the Supporting Information.
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-
-
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20
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84873831141
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Compounds 3-6 are analogues of known sulfone-based COX inhibitors. Compound 3:
-
Compounds 3-6 are analogues of known sulfone-based COX inhibitors. Compound 3:
-
-
-
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21
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0033535523
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Compound 4:
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W. C. Black, C. Brideau, C. C. Chan, S. Charleson, N. Chauret, D. Claveau, D. Ethier, R. Gordon, G. Greig, J. Guay, G. Hughes, P. Jolicoeur, Y. Leblanc, D. Nicoll-Griffith, N. Ouimet, D. Riendeau, D. Visco, Z. Wang, L. Xu, P. Prasit, J. Med. Chem. 1999, 42, 1274; Compound 4:
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Hughes, G.11
Jolicoeur, P.12
Leblanc, Y.13
Nicoll-Griffith, D.14
Ouimet, N.15
Riendeau, D.16
Visco, D.17
Wang, Z.18
Xu, L.19
Prasit, P.20
more..
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22
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0032491270
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Compound 5:
-
R. W. Friesen, C. Brideau, C. C. Chan, S. Charleson, D. Deschênes, D. Dubé, D. Ethier, R. Fortin, J. Y. Gauthier, Y. Girard, R. Gordon, G. M. Greig, D. Riendeau, C. Savoie, Z. Wang, E. Wong, D. Visco, L. J. Xu, R. N. Young, Bioorg. Med. Chem. Lett. 1998, 8, 2777; Compound 5:
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Bioorg. Med. Chem. Lett.
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Friesen, R.W.1
Brideau, C.2
Chan, C.C.3
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Dubé, D.6
Ethier, D.7
Fortin, R.8
Gauthier, J.Y.9
Girard, Y.10
Gordon, R.11
Greig, G.M.12
Riendeau, D.13
Savoie, C.14
Wang, Z.15
Wong, E.16
Visco, D.17
Xu, L.J.18
Young, R.N.19
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23
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84873833367
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5-Arylpyrazole Compounds, K. Nakamura, T. Terasaka, T. Ogino, Y. Noda, T. Manabe, Fujisawa Pharmaceuticals Co. Ltd, Osaka, Japan), WO/1999/25695A1
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5-Arylpyrazole Compounds, K. Nakamura, T. Terasaka, T. Ogino, Y. Noda, T. Manabe, (Fujisawa Pharmaceuticals Co. Ltd, Osaka, Japan), WO/1999/25695A1, 1999;
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(1999)
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-
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24
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13444266910
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In analogy to celecoxib as reported in, Compound 6:
-
In analogy to celecoxib as reported in T. D. Penning, J. J. Talley, S. R. Bertenshaw, J. S. Carter, P. W. Collins, S. Docter, M. J. Graneto, L. F. Lee, J. W. Malecha, J. M. Miyashiro, R. S. Rogers, D. J. Rogier, S. S. Yu, G. D. Anderson, E. G. Burton, J. N. Cogburn, S. A. Gregory, C. M. Koboldt, W. E. Perkins, K. Seibert, A. W. Veenhuizen, Y. Y. Zhang, P. C. Isakson, J. Med. Chem. 1997, 40, 1347; Compound 6:
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J. Med. Chem.
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Penning, T.D.1
Talley, J.J.2
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Carter, J.S.4
Collins, P.W.5
Docter, S.6
Graneto, M.J.7
Lee, L.F.8
Malecha, J.W.9
Miyashiro, J.M.10
Rogers, R.S.11
Rogier, D.J.12
Yu, S.S.13
Anderson, G.D.14
Burton, E.G.15
Cogburn, J.N.16
Gregory, S.A.17
Koboldt, C.M.18
Perkins, W.E.19
Seibert, K.20
Veenhuizen, A.W.21
Zhang, Y.Y.22
Isakson, P.C.23
more..
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25
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0025160887
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Schmidt, W.K.6
Smith, C.7
Hewes, W.E.8
Ackerman, N.R.9
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26
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84873821681
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Experimental details and analytical data for all products are given in the Supporting Information.
-
Experimental details and analytical data for all products are given in the Supporting Information.
-
-
-
-
27
-
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84873815314
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-
Because enantiopure 6 was noncrystalline, the absolute configuration was assigned by comparing calculated and measured electronic circular dichroism (ECD) spectra. Unfortunately, significant peak shifts and signal fluctuations were observed, allowing only tentative data interpretation. Accordingly, compounds 6-A and 6-B are believed to have the R and S configuration, respectively. For details, see the Supporting Information.
-
Because enantiopure 6 was noncrystalline, the absolute configuration was assigned by comparing calculated and measured electronic circular dichroism (ECD) spectra. Unfortunately, significant peak shifts and signal fluctuations were observed, allowing only tentative data interpretation. Accordingly, compounds 6-A and 6-B are believed to have the R and S configuration, respectively. For details, see the Supporting Information.
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-
-
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30
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84873826363
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Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, US National Cancer Institute (NCI)/National Institutes of Health (NIH);
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Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, US National Cancer Institute (NCI)/National Institutes of Health (NIH); http://dtp.cancer.gov.
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31
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84873818062
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All one-dose-mean graphs for compounds 2c, 3-6 and the five-dose-response curve for compound 6 are presented in the Supporting Information.
-
All one-dose-mean graphs for compounds 2c, 3-6 and the five-dose-response curve for compound 6 are presented in the Supporting Information.
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32
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0023852747
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Fusenig, N.E.6
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in, 2nded., Eds.: W. Krämer, U. Schirmer, P. Jeschke, M. Witschel), Wiley-VCH, Weinheim
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Joint United Nations Food and Agriculture Organization (FAO)/World Health Organization (WHO) Meeting on Pesticide Residues (JMPR), report no. 252, 2011 (available here: http://www.fao.org/publications/en/).
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G. Reifferscheid, H. M. Maes, B. Allner, J. Badurova, S. Belkin, K. Bluhm, F. Brauer, J. Bressling, S. Domeneghetti, T. Elad, S. Flückinger-Isler, H. J. Grummt, R. Gürtler, A. Hecht, M. B. Heringa, H. Hollert, S. Huber, M. Kramer, A. Magdeburg, H. T. Ratte, R. Sauerborn-Klobucar, A. Sokolowski, P. Soldan, T. Smital, D. Stalter, P. Venier, C. Ziemann, J. Zipperle, S. Buchinger, Environ. Mol. Mutagen. 2012, 53, 185.
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Reifferscheid, G.1
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Allner, B.3
Badurova, J.4
Belkin, S.5
Bluhm, K.6
Brauer, F.7
Bressling, J.8
Domeneghetti, S.9
Elad, T.10
Flückinger-Isler, S.11
Grummt, H.J.12
Gürtler, R.13
Hecht, A.14
Heringa, M.B.15
Hollert, H.16
Huber, S.17
Kramer, M.18
Magdeburg, A.19
Ratte, H.T.20
Sauerborn-Klobucar, R.21
Sokolowski, A.22
Soldan, P.23
Smital, T.24
Stalter, D.25
Venier, P.26
Ziemann, C.27
Zipperle, J.28
Buchinger, S.29
more..
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84873873087
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Water quality-Determination of the genotoxicity of water and wastewater using the Salmonella/microsome fluctuation test (Ames fluctuation test), International Standards Organization (ISO), document no. ISO11350, 2012.
-
Water quality-Determination of the genotoxicity of water and wastewater using the Salmonella/microsome fluctuation test (Ames fluctuation test), International Standards Organization (ISO), document no. ISO11350, 2012.
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-
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37
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84873805937
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For test principles and experimental details, see the Supporting Information.
-
For test principles and experimental details, see the Supporting Information.
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