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Volumn 8, Issue 2, 2013, Pages 217-220

N-Cyano Sulfoximines: COX Inhibition, Anticancer Activity, Cellular Toxicity, and Mutagenicity

Author keywords

Cancer; Cyclooxygenases; Cytotoxicity; Inhibitors; N cyano sulfoximines

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; N CYANO SULFOXIMINE; UNCLASSIFIED DRUG;

EID: 84873843984     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200403     Document Type: Article
Times cited : (94)

References (37)
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    • For two representative examples from the patent literature, see:
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    • For advanced syntheses of N-cyano sulfoximines, see:
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    • For a related study demonstrating COX inhibition and estrogen receptor binding of sulfoximines with a triaryl olefin core, see
    • For a related study demonstrating COX inhibition and estrogen receptor binding of sulfoximines with a triaryl olefin core, see: X. Y. Chen, S. J. Park, H. Buschmann, M. DeRosa, C. Bolm, Bioorg. Med. Chem. Lett. 2012, 22, 4307.
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    • 50 values are given in the Supporting Information.
    • 50 values are given in the Supporting Information.
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    • Compounds 3-6 are analogues of known sulfone-based COX inhibitors. Compound 3:
    • Compounds 3-6 are analogues of known sulfone-based COX inhibitors. Compound 3:
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    • Experimental details and analytical data for all products are given in the Supporting Information.
    • Experimental details and analytical data for all products are given in the Supporting Information.
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    • Because enantiopure 6 was noncrystalline, the absolute configuration was assigned by comparing calculated and measured electronic circular dichroism (ECD) spectra. Unfortunately, significant peak shifts and signal fluctuations were observed, allowing only tentative data interpretation. Accordingly, compounds 6-A and 6-B are believed to have the R and S configuration, respectively. For details, see the Supporting Information.
    • Because enantiopure 6 was noncrystalline, the absolute configuration was assigned by comparing calculated and measured electronic circular dichroism (ECD) spectra. Unfortunately, significant peak shifts and signal fluctuations were observed, allowing only tentative data interpretation. Accordingly, compounds 6-A and 6-B are believed to have the R and S configuration, respectively. For details, see the Supporting Information.
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    • All one-dose-mean graphs for compounds 2c, 3-6 and the five-dose-response curve for compound 6 are presented in the Supporting Information.
    • All one-dose-mean graphs for compounds 2c, 3-6 and the five-dose-response curve for compound 6 are presented in the Supporting Information.
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    • For test principles and experimental details, see the Supporting Information.
    • For test principles and experimental details, see the Supporting Information.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.