Lutein suppresses inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2 microglia

Molecular Nutrition and Food Research

Volumn 59, Issue 9, 2015, Pages 1663-1673

  Wu, Wanqiang ^a   Li, Yuelian ^a   Wu, Yue ^a   Zhang, Yawen ^a   Wang, Zhen ^a   Liu, Xuebo ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

Lutein; Microglia; Neuroinflammation; NF B; Nrf2

Indexed keywords

CYCLOOXYGENASE 2; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NFE2L2 PROTEIN, MOUSE; NITRIC OXIDE; NOS2 PROTEIN, MOUSE; PROTEIN KINASE B; PTGS2 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; XANTHOPHYLL;

ANIMAL; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; GENETICS; INFLAMMATION; METABOLISM; MICROGLIA; MOUSE; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; HEME OXYGENASE-1; INFLAMMATION; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; LUTEIN; MICE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURODEGENERATIVE DISEASES; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84942824931     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201500109     Document Type: Article

References (35)

1. Block, M. L., Zecca, L., Hong, J. S., Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 2007, 8, 57-69.
2. Long-Smith, C. M., Sullivan, A. M., Nolan, Y. M., The influence of microglia on the pathogenesis of Parkinson's disease. Prog. Neurobiol. 2009, 89, 277-287.
3. Amor, S., Puentes, F., Baker, D., van der Valk, P., Inflammation in neurodegenerative diseases. Immunology 2010, 129, 154-169.
4. Lue, L. F., Kuo, Y. M., Beach, T., Walker, D. G., Microglia activation and anti-inflammatory regulation in Alzheimer's disease. Mol. Neurobiol. 2010, 41, 115-128.
5. Dai, J. N., Zong, Y., Zhong, L. M., Li, Y. M. et al., Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PLoS One 2011, 6, 1-9.
6. Yuan, L., Wu, Y. C., Ren, X. M., Liu, Q. et al., Isoorientin attenuates lipopolysaccharide-induced pro-inflammatory responses through down-regulation of ROS-related MAPK/NF-kappa B signaling pathway in BV-2 microglia. Mol. Cell. Biochem. 2014, 386, 153-165.
7. Olumayokun, A. O., Asit, K., Ravikanth, V., Uchechukwu, P. O. et al., Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia. Mol. Nutr. Food Res. 2014, 58, 1843-1851.
8. 2 in NF-kappa B activation. Free Radic. Biol. Med. 2008, 45, 885-896.
9. Kundu, J. K., Surh, Y. J., Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals. Mutat. Res. 2005, 591, 123-146.
10. Lee, J. W., Bae, C. J., Choi, Y. J., Kim, S. I. et al., 3, 4, 5-Trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced endotoxemia model in vivo. Mol. Cell. Biochem. 2014, 390, 143-153.
11. de Vries, H. E., Witte, M., Hondius, D., Rozermuller, A. J. M. et al., Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease? Free Radic. Biol. Med. 2008, 45, 1375-1383.
12. Rafi, M. M., Shafaie, Y., Dietary lutein modulates inducible nitric oxide synthase (iNOS) gene and protein expression in mouse macrophage cells (RAW 264.7). Mol. Nutr. Food Res. 2007, 51, 333-340.
13. Johnson, E. J., A possible role for lutein and zeaxanthin in cognitive function in the elderly. Am. J. Clin. Nutr. 2012, 96, 1161s-1165s.
14. Kim, Y., Seo, J. H., Kim, H., beta-Carotene and lutein inhibit hydrogen peroxideinduced activation of NF-kappa B and IL-8 expression in gastric epithelial AGS cells. J. Nutr. Sci. Vitaminol. 2011, 57, 216-223.
15. Kijlstra, A., Tian, Y., Kelly, E. R., Berendschot, T. T., Lutein: more than just a filter for blue light. Prog. Retin. Eye Res. 2012, 31, 303-315.
16. Wang, H., Joseph, J. A., Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic. Biol. Med. 1999, 27, 612-616.
17. Craft, N. E., Haitema, T. B., Garnett, K. M., Fitch, K. A. et al., Carotenoid, tocopherol, and retinol concentrations in elderly human brain. J. Nutr. Health Aging 2004, 8, 156-162.
18. Vishwanathan, R., Neuringer, M., Snodderly, D. M., Johnson, E. J. et al. Macular lutein and zeaxanthin are related to brain lutein and zeaxanthin in primates. Nutr Neurosci. 2013, 16(1), 21-29.
19. Abbott, N. J., Friedman, A., Overview and introduction: the blood-brain barrier in health and disease. Epilepsia 2012, 53, 1-6.
20. Kidd, P., Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential. Altern. Med. Rev. 2011, 16, 355-364.
21. Li, B. X., Vachali, P., Bernstein, P. S., Human ocular carotenoid-binding proteins. Photochem. Photobiol. Sci. 2010, 9, 1418-1425.
22. Qin, L. Y., Wu, X. F., Block, M. L., Liu, Y. X. et al., Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 2007, 55, 453-462.
23. Kim, Y. H., Koh, H. K., Kim, D. S., Down-regulation of IL-6 production by astaxanthin via ERK-, MSK-, and NF-κB-mediated signals in activated microglia. Int. Immunopharmacol. 2010, 10, 1560-1572.
24. Choi, S. K., Park, Y. S., Choi, D. K., Chang, H. I., Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells. J. Microbiol. Biotechnol. 2008, 18, 1990-1996.
25. Lin, H. Y., Huang, B. R., Yeh, W. L., Lee, C. H. et al., Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/ heme oxygenase-1 pathways. Neurobiol. Aging 2014, 35, 191-202.
26. Speciale, A., Anwar, S., Canali, R., Chirafisi, J. et al., Cyanidin-3-O-glucoside counters the response to TNF-alpha of endothelial cells by activating Nrf2 pathway. Mol. Nutr. Food Res. 2013, 57, 1979-1987.
27. Surh, Y. J., Kundu, J. K., Na, H. K., Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med. 2008, 74, 1526-1539.
28. Buelna-Chontal, M., Zazueta, C., Redox activation of Nrf2 & NF-κB: a double end sword? Cell. Signal. 2013, 25, 2548-2557.
29. Kaulmann, A., Bohn, T., Carotenoids, inflammation, and oxidative stress- implications of cellular signaling pathways and relation to chronic disease prevention. Nutr. Res. 2014, 34, 907-929.
30. Ben-Dor, A., Steiner, M., Gheber, L., Danilenko, M. et al. Carotenoids activate the antioxidant response element transcription system. Mol. Cancer Ther. 2005, 4, 177-186.
31. Linnewiel, K., Ernst, H., Caris-Veyrat, C., Ben-Dor, A. et al., Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system. Free Radic. Biol. Med. 2009, 47, 659-667.
32. Liu, G. H., Qu, J., Shen, X., NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim. Biophys. Acta 2008, 1783, 713-727.
33. Eroglu, A., Harrison, E. H., Carotenoid metabolism in mammals, including man: formation, occurrence, and function of apocarotenoids. J. Lipid Res. 2013, 54, 1719-1730.
34. Khachik, F., de Moura, F.F., Chew, E.Y., Douglass, L.W. et al., The effect of lutein and zeaxanthin supplementation on metabolites of these carotenoids in the serum of persons aged 60 or older. Invest. Ophthalmol. Vis. Sci. 2006, 47, 5234-5242.
35. Yonekura, L., Kobayashi, M., Terasaki, M., Nagao, A., Keto-carotenoids are the major metabolites of dietary lutein and fucoxanthin in mouse tissues. J. Nutr. 2010, 140, 1824-1831.