Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs

European Journal of Medicinal Chemistry

Volumn 92, Issue , 2015, Pages 439-448

  Wang, Hao Meng ^a   Zhang, Li ^a   Liu, Jiang ^a   Yang, Zhao Liang ^a   Zhao, Hong Ye ^a   Yang, Yao ^a   Shen, Di ^a   Lu, Kui ^a   Fan, Zhen Chuan ^a,b   Yao, Qing Wei ^c   Zhang, Yong Min ^d   Teng, Yu Ou ^a   Peng, Yu ^a  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Obesita and Algaegen LLC   (United States)

^c Sphinx Scientific Laboratory   (United States)

^d SORBONNE UNIVERSITÉ   (France)

Author keywords

Antitumor agents; Apoptosis; Geranylated chalcones; K562 cell; Prenyled chalcones

Indexed keywords

1 [2,4 DIMETHOXY 3,5 BIS(3 METHYLBUT 2 EN 1 YL)PHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [2,4 DIMETHOXY 5 (3 METHYLBUT 2 EN 1 YL)PHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [3 (3,7 DIMETHYLOCTA 2,6 DIEN 1 YL) 2,4 DIMETHOXY 5 (3 METHYL BUT 2 EN 1 YL)PHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [3 (3,7 DIMETHYLOCTA 2,6 DIEN 1 YL) 5 (3,7 DIMETHYLOCTA 2,6 DIEN 1 YL) 2,4 DIMETHOXYPHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [5 (3,7 DIMETHYLOCTA 2, 6 DIEN 1 YL) 2,4 DIMETHOXYPHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; BAVACHALCONE; CAMPTOTHECIN; CHALCONE DERIVATIVE; ISOBAVACHALCONE; ISOLIQUIRITIGEIN; ISOXANTHOANGELOL; UNCLASSIFIED DRUG; XANTHOANGELOL; BIOLOGICAL PRODUCT; CHALCONE;

ALDOL REACTION; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IODINATION; LEUKEMIA; PROTON NUCLEAR MAGNETIC RESONANCE; SUZUKI REACTION; UMBILICAL VEIN ENDOTHELIAL CELL; ANALOGS AND DERIVATIVES; APOPTOSIS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; K562 CELL LINE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VASCULAR ENDOTHELIUM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL PRODUCTS; CELL PROLIFERATION; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; K562 CELLS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84920757261     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.01.007     Document Type: Article

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