Characterization of Korean red ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition

Journal of Ginseng Research

Volumn 39, Issue 4, 2015, Pages 384-391

  Lee, Sang Myung ^a   Bae, Bong Seok ^b   Park, Hee Weon ^b   Ahn, Nam Geun ^b   Cho, Byung Gu ^b   Cho, Yong Lae ^b   Kwak, Yi Seong ^b  

^a Mokwon University   (South Korea)

^b Korea Ginseng Corporation   (South Korea)

Author keywords

Chemical components; Historical document; Preparation methods; Red ginseng (Panax ginseng meyer)

Indexed keywords

ARGININE; FRUCTOSE; GINSENOSIDE; GINSENOSIDE F 4; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 10; GINSENOSIDE RG 3; GINSENOSIDE RG 5; GINSENOSIDE RG 6; GINSENOSIDE RG 9; GINSENOSIDE RH 1; GINSENOSIDE RH 4; GINSENOSIDE RK 1; GINSENOSIDE RK 3; GINSENOSIDE RZ 1; GLUCOSE; POLYSACCHARIDE; UNCLASSIFIED DRUG;

BIOLOGICAL ACTIVITY; CHEMICAL COMPOSITION; CONCENTRATION PROCESS; DRUG STRUCTURE; DRUG SYNTHESIS; FINE ROOT; GINSENG; HUMAN; PLANT ROOT; PRIORITY JOURNAL; REVIEW; RHIZOME; TRADITIONAL MEDICINE;

EID: 84942816489     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jgr.2015.04.009     Document Type: Review

References (35)

1. Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol 1969;9:419-30.
2. Kim YJ, Lee OR, Lee SY, Kim KT, Yang DC. Isolation and characterization of the glutathione s-transferase gen from Panax ginseng C.A. Meyer. J Ginseng Res 2012;36:449-60.
3. Liu CX, Xio PG. Recent advances on ginseng research in China. J Ethnopharmacol 1992;35:27-38.
4. Wang J, Li SS, Fan YY, Chen Y, Liu D, Cheng HR, Gao XG, Zhou YF. Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C.A. Meyer. J Ethnopharmacol 2010;130:421-3.
5. Babiker LB, Gadkariem EA, Alashban RM, Aljohar HI. Investigation of stability of Korean ginseng in herbal drug product. Am J Appl Sci 2014;11:160-70.
6. Zhang DT, Yasuda YY, Zheng P, Kawabata T. ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation. Free Radic Biol Med 1996;20: 145-50.
7. Yun TK, Choi SY, Yun HY. Epidemiological study on cancer prevention by ginseng: Are all kinds of cancers preventable by ginseng. J Korean Med Sci 2001:S19-27.
8. Joo SS, Won TJ, Lee I. Reciprocal activity of ginsenosides in the production of proinflammatory repertoire and their potential roles in neuroprotection in vivo. Planta Med 2005;71:476-81.
9. Jung CH, Seog HM, Choi IW, Choi HD, Cho HY. Effects of wild ginseng (panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats. J Ethnopharmacol 2005;98: 245-50.
10. Nam KY. The comparative understanding between red ginseng and white ginsengs processed ginsengs (Panax ginseng C.A. Meyer). J Ginseng Res 2005;29:1-18.
11. Baeg IH, So SH. The world ginseng mark and ginseng (Korea). J Ginseng Res 2013;37:1-7.
12. Christensen LP. Ginsenosides: chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009;55:1-73.
13. Lee SM, Kim SC, Oh JS, Kim JH, Na MK. 20(R)-Ginsenoside Rf: A new ginsenoside from red ginseng extract. Phytochem Lett 2013;6:620-4.
14. Lee SM. Thermal conversion pathways of ginsenoside in red ginseng processing. Nat Prod Sci 2014;20:119-25.
15. Ahn IO, Lee SS, Lee JH, Lee MJ, Cho BG. Comparison of ginsenoside contents and pattern similarity between root parts of new cultivars in Panax ginseng C.A. Meyer. J Ginseng Res 2008;32:15-8.
16. Kitagawa I, Taniyama T, Hayashi T, Yoshikawa M. Malonylginsenoside Rb1, Rb2, Rc, and Rd, four new malonylated dammarane-type triterpen oligosaccharides from Ginseng Radix. Chem Pharm Bull 1983;31:3353-6.
17. Cho EJ, Piao XL, Jang MH, Baek SH, Kim HY, Kang SK, Kwon SW, Park JH. The effect of steaming on the free amino acid contents and antioxidant activity of Panax ginseng. Food Chem 2008;107:876-82.
18. Du QQ, Liu SY, Xu RF, Li M, Song FR, Liu ZQ. Studies on structures and activities of initial Maillard reaction products by electrospray ionization mass spectrometry combined with liquid chromatography in processing of red ginseng. Food Chem 2012;135:832-8.
19. Suzuki Y, Choi KJ, Uchida K, Ko SR, Shon HJ, Park JD. Arginyl-fructosyl-glucose and arginyl-fructose, compounds related to browning reaction in the model system of steaming and heat-drying process for the preparation of red ginseng. J Ginseng Res 2004;28:143-8.
20. Okuda H. Inhibitory substances in Korean red ginseng toward toxohormone L: A toxic substance secreted from tumor cells. The Ginsneg Rev 1992;15:34-7.
21. Nadeem AA, Moinuddin, Alam K, Ali A. Preferential recognition of amadoririch lycine residues by serum antibodies in diabetes mellitus: Role of protein glycation in the disease process. Hum Immunol 2009;70:417-24.
22. Arif B, Ashraf JM, Moinuddin, Ahmed J, Arif Z, Alam K. Structural and immunological characterization of amadori-rich human serum albumin: Role in diabetes mellitus. Arch Biochem Biophys 2012;522:17-25.
23. Ha KS, Jo SH, Kang BH, Apostolidis E, Lee MS, Jang HD, Kwon YI. In vitro and in vivo antihyperglycemic effect of 2 amadori rearrangement compounds, arginyl-fructose and arginyl-fructosyl-glucose. J Food Sci 2011;76:H188-93.
24. Fu P, Gao Q, Wan W, Jiang R, Zhong C, Jiao L. Chemical properties and antitumor activity of polysaccharides from roots of Panax ginseng. J Norman Bethune University of Medical Science 1994;20:439-41.
25. Lee JH, Shim JS, Kim MK, Chung MS, Kim KH. Pectin-like acid polysaccharide from Panax ginseng which selective anti-adhesive activity against pathogenic bacteria. Carbohydr Res 2006;342:1154-63.
26. Luo D, Fang B. Structural identification of ginseng polysaccharides and testing of their antioxidant activities. Carbohydr Polym 2008;72:376-81.
27. Shin MJ, Kim YS, Kwak YS, Song YB, Kim YS, Park JD. Enhancement of antitumor effects of paclitaxel (taxol) in combination with red ginseng acidic polysaccharide (RGAP). Planta Med 2004;70:1033-8.
28. Song JY, Han SK, Son EH, Pyo SN, Yun YS, Yi SY. Induction of secretory and tumoricidal activities in peritoneal macrophages by ginsan. Int Immunopharmacol 2002;2:857-65.
29. Suzuki Y, Hikino H. Mechanism of hypoglycemic activity of Panaxans A and B. glycans of Panax ginseng roots: Effects on the key enzymes of glucose metabolism in the liver of mice. Phytother Res 1989;3:15-9.
30. Kwak YS, Kyung JS, Kim JS, Cho JY, Rhee MH. Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng. Biol Pharm Bull 2010;33:468-72.
31. Byeon SE, Lee JH, Kim JH. Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng. Mediators of Inflammation 2012;732860:7.
32. Wang J, Sun C, Zheng Y, Pan H, Zhou Y, Fan Y. The effective mechanism of the polysaccharides from Panax ginseng on chronic fatigue syndrome. Arch Pharm Res 2014;37:530-8.
33. Zhang X, Yu L, Bi H, Li X, Ni W, Han H, Li N, Wang B, Zhou Y, Tai G. Total fractionation and characterization of the water soluble polysaccharides isolated from Panax ginseng C.A. Meyer. Carbohydr Polym 2009;77:544-52.
34. Takahashi M, Yoshikura M. Studies on the components of Panax ginseng C. A. Meyer. V. On the structure of a new acetylene derivative ‘Panaxynol’ (3). Synthesis of 1,9-(cis)-heptadecadiene- 4,6-diyn-3-O. Yakugaku Zasshi 1966;86:1053-5.
35. Poplawski I, Wrobel JJ, Glinka M. Panaxydol, a new polyacetylenic epoxide from Panax ginseng roots. Phytochemistry 1980;19:1539-41.