Genetics of insulin resistance in polycystic ovary syndrome

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 18, Issue 4, 2015, Pages 401-406

  Obermayer Pietsch, Barbara ^a   Trummer, Christian ^a   Schwetz, Verena ^a   Schweighofer, Natascha ^a   Pieber, Thomas ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Androgens; Genetics; Insulin resistance; Polycystic ovary syndrome; Type 2 diabetes mellitus

Indexed keywords

INSULIN;

BODY WEIGHT; CHRONIC INFLAMMATION; FAMILY HISTORY; FEMALE; GENETIC ASSOCIATION; HUMAN; INSULIN RESISTANCE; MOLECULAR GENETICS; MOLECULAR PATHOLOGY; NONHUMAN; OVARY POLYCYSTIC DISEASE; PHARMACOGENETICS; REVIEW; ENERGY METABOLISM; FEMALE INFERTILITY; GENETICS; NON INSULIN DEPENDENT DIABETES MELLITUS;

DIABETES MELLITUS, TYPE 2; ENERGY METABOLISM; FEMALE; HUMANS; INFERTILITY, FEMALE; INSULIN RESISTANCE; PHARMACOGENETICS; POLYCYSTIC OVARY SYNDROME;

EID: 84942804008     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000190     Document Type: Review

References (27)

1. Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41-47.
2. Azziz R, Carmina E, Dewailly D, et al. Task Force on the Phenotype of the Polycystic Ovary Syndrome of The Androgen Excess and PCOS Society. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: The complete task force report. Fertil Steril 2009; 91: 456-488.
3. Jayasena CN, Franks S. The management of patients with polycystic ovary syndrome. Nat Rev Endocrinol 2014; 10: 624-636.
4. Vélez LM, Motta AB. Association between polycystic ovary syndrome and metabolic syndrome. Curr Med Chem 2014; 21: 3999-4012.
5. Yaghootkar H, Scott RA, White CC, et al. Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes. Diabetes 2014; 63: 4369-4377.
6. Ibáñez L, Ong KK, López-Bermejo A, et al. Hyperinsulinaemic androgen excess in adolescent girls. Nat Rev Endocrinol 2014; 10: 499-508.
7. Della Torre S, Benedusi V, Fontana R, Maggi A. Energy metabolism and fertility: A balance preserved for female health. Nat Rev Endocrinol 2014; 10: 13-23.
8. Dumesic DA, Abbott DH, Padmanabhan V. Polycystic ovary syndrome and its developmental origins. Rev Endocr Metab Disord 2007; 8: 127-141.
9. Lerchbaum E, Trummer O, Giuliani A, et al. Susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21, and 9q33.3 in a cohort of Caucasian women. Horm Metab Res 2011; 43: 743-747.
10. Chen L, Xu WM, Zhang D. Association of abdominal obesity, insulin resistance, and oxidative stress in adipose tissue in women with polycystic ovary syndrome. Fertil Steril 2014; 102: 1167-1174.
11. Roemer KL, Young SL, Savaris RF. Characterization of GAB1 expression over the menstrual cycle in women with and without polycystic ovarian syndrome provides a new insight into its pathophysiology. J Clin Endocrinol Metab 2014; 99: E2162-E2168.
12. Raja-Khan N, Urbanek M, Rodgers RJ, Legro RS. The role of TGF-b in polycystic ovary syndrome. Reprod Sci 2014; 21: 20-31.
13. Quilter CR, Cooper WN, Cliffe KM, et al. Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk. FASEB J 2014; 28: 4868-4879.
14. Lerchbaum E, Schwetz V, Giuliani A, Obermayer-Pietsch B. Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women. Eur J Endocrinol 2014; 170: 727-739.
15. Keramati AR, Fathzadeh M, Mani A. A form of the metabolic syndrome associated with mutations in DYRK1B. N Engl J Med 2014; 371: 785-786.
16. Scott RA, Fall T, Pasko D, et al., RISC Study Group; EPIC-InterAct Consortium. Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity. Diabetes 2014; 63: 4378-4387.
17. Prokopenko I, Poon W, Mäqi R, et al. A central role for GRB10 in regulation of islet function in man. PLoS Genet 2014; 10: E1004235.
18. Tang Y, Axelsson AS, Spé gel P, et al. Genotype-based treatment of type 2 diabetes with an a2A-adrenergic receptor antagonist. Sci Transl Med 2014; 6: 257ra139.
19. Lenarcik-Kabza A, Laczmań ski L, Milewicz A, et al. The influence of endocannabinoid receptor 1 gene variations on anthropometric and metabolic parameters of women with polycystic ovary syndrome. Endokrynol Pol 2014; 65: 181-188.
20. Thathapudi S, Kodati V, Erukkambattu J, et al. Tumor necrosis factor-alpha and polycystic ovarian syndrome: A clinical, biochemical, and molecular genetic study. Genet Test Mol Biomarkers 2014; 18: 605-609.
21. Bhatt S, Mutharasan P, Garcia OA, et al. The inflammatory gene pathway is not a major contributor to polycystic ovary syndrome. J Clin Endocrinol Metab 2014; 99: E567-E571.
22. Lam UD, Lerchbaum E, Schweighofer N, et al. Association of MEP1A gene variants with insulin metabolism in central European women with polycystic ovary syndrome. Gene 2014; 537: 245-252.
23. Baldani DP, Skrgatic L, Cerne JZ, et al. Association of PPARG/Pro12Ala polymorphism with insulin sensitivity and body mass index in patients with polycystic ovary syndrome. Biomed Rep 2014; 2: 199-206.
24. Yang Z, Yang X, Xu J, et al. Association between adiponectin receptor 1 gene polymorphism and insulin resistance in Chinese patients with polycystic ovary syndrome. Gynecol Obstet Invest 2014; 77: 45-49.
25. Ben-Salem A, Ajina M, Suissi M, et al. Polymorphisms of transcription factor-7- like 2 (TCF7L2) gene in Tunisian women with polycystic ovary syndrome (PCOS). Gene 2014; 533: 554-557.
26. Schweighofer N, Lerchbaum E, Trummer O, et al. Metformin resistance alleles in polycystic ovary syndrome: Pattern and association with glucose metabolism. Pharmacogenomics 2014; 15: 305-317.
27. Gaberscek S, Zaletel K, Schwetz V, et al. Mechanisms in endocrinology: Thyroid and polycystic ovary syndrome. Eur J Endocrinol 2015; 172: R9-R21.