-
1
-
-
84859973999
-
-
[CrossRef] [PubMed]
-
Christakos, S.; Ajibade, D.V.; Dhawan, P.; Fechner, A.J.; Mady, L.J. Vitamin D: Metabolism. Rheum. Dis. Clin. N. Am. 2012, 38, 1–11. [CrossRef] [PubMed]
-
(2012)
Metabolism. Rheum. Dis. Clin. N. Am
, vol.38
, pp. 1-11
-
-
Christakos, S.1
Ajibade, D.V.2
Dhawan, P.3
Fechner, A.J.4
Mady, L.J.5
Vitamin, D.6
-
2
-
-
2442699046
-
Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
-
[CrossRef] [PubMed]
-
Cheng, J.B.; Levine, M.A.; Bell, N.H.; Mangelsdorf, D.J.; Russell, D.W. Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc. Natl. Acad. Sci. USA 2004, 101, 7711–7715. [CrossRef] [PubMed]
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 7711-7715
-
-
Cheng, J.B.1
Levine, M.A.2
Bell, N.H.3
Mangelsdorf, D.J.4
Russell, D.W.5
-
3
-
-
84884597662
-
CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo
-
[CrossRef] [PubMed]
-
Zhu, J.G.; Ochalek, J.T.; Kaufmann, M.; Jones, G.; Deluca, H.F. CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo. Proc. Natl. Acad. Sci. USA 2013, 110, 15650–15655. [CrossRef] [PubMed]
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 15650-15655
-
-
Zhu, J.G.1
Ochalek, J.T.2
Kaufmann, M.3
Jones, G.4
Deluca, H.F.5
-
4
-
-
77950658080
-
Vitamin D gene regulation
-
3rd ed.; Bilezikian, J.P., Raisz, L.G., Eds.; Elsevier: San Diego, CA, USA
-
Christakos, S. Vitamin D gene regulation. In Principles of Bone Biology, 3rd ed.; Bilezikian, J.P., Raisz, L.G., Eds.; Elsevier: San Diego, CA, USA, 2008; Volume 1, pp. 770–794.
-
(2008)
Principles of Bone Biology
, vol.1
, pp. 770-794
-
-
Christakos, S.1
-
5
-
-
84873710626
-
Molecular mechanisms of vitamin D action
-
[CrossRef] [PubMed]
-
Haussler, M.R.; Whitfield, G.K.; Kaneko, I.; Haussler, C.A.; Hsieh, D.; Hsieh, J.C.; Jurutka, P.W. Molecular mechanisms of vitamin D action. Calcif. Tissue Int. 2013, 92, 77–98. [CrossRef] [PubMed]
-
(2013)
Calcif. Tissue Int
, vol.92
, pp. 77-98
-
-
Haussler, M.R.1
Whitfield, G.K.2
Kaneko, I.3
Haussler, C.A.4
Hsieh, D.5
Hsieh, J.C.6
Jurutka, P.W.7
-
6
-
-
84906790954
-
Fundamentals of vitamin D hormone-regulated gene expression
-
[CrossRef] [PubMed]
-
Pike, J.W.; Meyer, M.B. Fundamentals of vitamin D hormone-regulated gene expression. J. Steroid Biochem. Mol. Biol. 2014, 144, 5–11. [CrossRef] [PubMed]
-
(2014)
J. Steroid Biochem. Mol. Biol
, vol.144
, pp. 5-11
-
-
Pike, J.W.1
Meyer, M.B.2
-
7
-
-
61349169039
-
AMPed up immunity: How antimicrobial peptides have multiple roles in immune defense
-
[CrossRef] [PubMed]
-
Lai, Y.; Gallo, R.L. AMPed up immunity: How antimicrobial peptides have multiple roles in immune defense. Trends Immunol. 2009, 30, 131–141. [CrossRef] [PubMed]
-
(2009)
Trends Immunol
, vol.30
, pp. 131-141
-
-
Lai, Y.1
Gallo, R.L.2
-
8
-
-
0028949278
-
Human CAP18: A novel antimicrobial lipopolysaccharide-binding protein
-
PubMed]
-
Larrick, J.W.; Hirata, M.; Balint, R.F.; Lee, J.; Zhong, J.; Wright, S.C. Human CAP18: A novel antimicrobial lipopolysaccharide-binding protein. Infect. Immun. 1995, 63, 1291–1297. PubMed]
-
(1995)
Infect. Immun
, vol.63
, pp. 1291-1297
-
-
Larrick, J.W.1
Hirata, M.2
Balint, R.F.3
Lee, J.4
Zhong, J.5
Wright, S.C.6
-
9
-
-
84871027267
-
A comprehensive summary of LL-37, the factotum human cathelicidin peptide
-
[CrossRef] [PubMed]
-
Vandamme, D.; Landuyt, B.; Luyten, W.; Schoofs, L. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol. 2012, 280, 22–35. [CrossRef] [PubMed]
-
(2012)
Cell Immunol
, vol.280
, pp. 22-35
-
-
Vandamme, D.1
Landuyt, B.2
Luyten, W.3
Schoofs, L.4
-
10
-
-
0038052326
-
Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37
-
[CrossRef] [PubMed]
-
Henzler, W.K.; Lee, D.K.; Ramamoorthy, A. Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37. Biochemistry 2003, 42, 6545–6558. [CrossRef] [PubMed]
-
(2003)
Biochemistry
, vol.42
, pp. 6545-6558
-
-
Henzler, W.K.1
Lee, D.K.2
Ramamoorthy, A.3
-
11
-
-
4344665018
-
Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression
-
[CrossRef] [PubMed]
-
Wang, T.T.; Nestel, F.P.; Bourdeau, V.; Nagai, Y.; Wang, Q.; Liao, J.; Tavera-Mendoza, L.; Lin, R.; Hanrahan, J.W.; Mader, S.et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J. Immunol. 2004, 173, 2909–2912. [CrossRef] [PubMed]
-
(2004)
J. Immunol
, vol.173
, pp. 2909-2912
-
-
Wang, T.T.1
Nestel, F.P.2
Bourdeau, V.3
Nagai, Y.4
Wang, Q.5
Liao, J.6
Tavera-Mendoza, L.7
Lin, R.8
Hanrahan, J.W.9
Mader, S.10
-
12
-
-
21744438757
-
Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3
-
[CrossRef] [PubMed]
-
Gombart, A.F.; Borregaard, N.; Koeffler, H.P. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005, 19, 1067–1077. [CrossRef] [PubMed]
-
(2005)
FASEB J
, vol.19
, pp. 1067-1077
-
-
Gombart, A.F.1
Borregaard, N.2
Koeffler, H.P.3
-
13
-
-
35648933859
-
Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D3
-
[CrossRef] [PubMed]
-
Yim, S.; Dhawan, P.; Ragunath, C.; Christakos, S.; Diamond, G. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D3. J. Cyst. Fibros. 2007, 6, 403–410. [CrossRef] [PubMed]
-
(2007)
J. Cyst. Fibros
, vol.6
, pp. 403-410
-
-
Yim, S.1
Dhawan, P.2
Ragunath, C.3
Christakos, S.4
Diamond, G.5
-
14
-
-
77954398213
-
Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future
-
[CrossRef] [PubMed]
-
White, J.H. Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: Past, present and future. J. Steroid Biochem. Mol. Biol. 2010, 121, 234–238. [CrossRef] [PubMed]
-
(2010)
J. Steroid Biochem. Mol. Biol
, vol.121
, pp. 234-238
-
-
White, J.H.1
-
15
-
-
33746087225
-
Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli
-
[CrossRef] [PubMed]
-
Schauber, J.; Dorschner, R.A.; Yamasaki, K.; Brouha, B.; Gallo, R.L. Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli. Immunology 2006, 118, 509–519. [CrossRef] [PubMed]
-
(2006)
Immunology
, vol.118
, pp. 509-519
-
-
Schauber, J.1
Dorschner, R.A.2
Yamasaki, K.3
Brouha, B.4
Gallo, R.L.5
-
16
-
-
62149136595
-
Induces innate antibacterial responses in human trophoblasts via an intracrine pathway
-
[CrossRef] [PubMed]
-
Liu, N.; Kaplan, A.T.; Low, J.; Nguyen, L.; Liu, G.Y.; Equils, O.; Hewison, M. Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway. Biol. Reprod. 2009, 80, 398–406. [CrossRef] [PubMed]
-
(2009)
Biol. Reprod
, vol.80
, pp. 398-406
-
-
Liu, N.1
Kaplan, A.T.2
Low, J.3
Nguyen, L.4
Liu, G.Y.5
Equils, O.6
Hewison, M.7
Vitamin, D.8
-
17
-
-
33645224419
-
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
-
[CrossRef] [PubMed]
-
Liu, P.T.; Stenger, S.; Li, H.; Wenzel, L.; Tan, B.H.; Krutzik, S.R.; Ochoa, M.T.; Schauber, J.; Wu, K.; Meinken, C et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006, 311, 1770–1773. [CrossRef] [PubMed]
-
(2006)
Science
, vol.311
, pp. 1770-1773
-
-
Liu, P.T.1
Stenger, S.2
Li, H.3
Wenzel, L.4
Tan, B.H.5
Krutzik, S.R.6
Ochoa, M.T.7
Schauber, J.8
Wu, K.9
Meinken, C.10
-
18
-
-
40649127503
-
Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3
-
[CrossRef] [PubMed]
-
Schauber, J.; Oda, Y.; Buchau, A.S.; Yun, Q.C.; Steinmeyer, A.; Zugel, U.; Bikle, D.D.; Gallo, R.L. Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3. J. Investig. Dermatol. 2008, 128, 816–824. [CrossRef] [PubMed]
-
(2008)
J. Investig. Dermatol
, vol.128
, pp. 816-824
-
-
Schauber, J.1
Oda, Y.2
Buchau, A.S.3
Yun, Q.C.4
Steinmeyer, A.5
Zugel, U.6
Bikle, D.D.7
Gallo, R.L.8
-
19
-
-
84911061366
-
C/EBPalpha and the vitamin D receptor cooperate in the regulation of cathelicidin in lung epithelial cells
-
[CrossRef] [PubMed]
-
Dhawan, P.; Wei, R.; Sun, C.; Gombart, A.F.; Koeffler, H.P.; Diamond, G.; Christakos, S. C/EBPalpha and the vitamin D receptor cooperate in the regulation of cathelicidin in lung epithelial cells. J. Cell Physiol. 2015, 230, 464–472. [CrossRef] [PubMed]
-
(2015)
J. Cell Physiol
, vol.230
, pp. 464-472
-
-
Dhawan, P.1
Wei, R.2
Sun, C.3
Gombart, A.F.4
Koeffler, H.P.5
Diamond, G.6
Christakos, S.7
-
20
-
-
49449112567
-
PU.1 and bacterial metabolites regulate the human gene CAMP encoding antimicrobial peptide LL-37 in colon epithelial cells
-
[CrossRef] [PubMed]
-
Termen, S.; Tollin, M.; Rodriguez, E.; Sveinsdottir, S.H.; Johannesson, B.; Cederlund, A.; Sjovall, J.; Agerberth, B.; Gudmundsson, G.H. PU.1 and bacterial metabolites regulate the human gene CAMP encoding antimicrobial peptide LL-37 in colon epithelial cells. Mol. Immunol. 2008, 45, 3947–3955. [CrossRef] [PubMed]
-
(2008)
Mol. Immunol
, vol.45
, pp. 3947-3955
-
-
Termen, S.1
Tollin, M.2
Rodriguez, E.3
Sveinsdottir, S.H.4
Johannesson, B.5
Cederlund, A.6
Sjovall, J.7
Agerberth, B.8
Gudmundsson, G.H.9
-
21
-
-
71249140211
-
Phenylbutyrate induces antimicrobial peptide expression
-
[CrossRef] [PubMed]
-
Steinmann, J.; Halldorsson, S.; Agerberth, B.; Gudmundsson, G.H. Phenylbutyrate induces antimicrobial peptide expression. Antimicrob. Agents Chemother. 2009, 53, 5127–5133. [CrossRef] [PubMed]
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, pp. 5127-5133
-
-
Steinmann, J.1
Halldorsson, S.2
Agerberth, B.3
Gudmundsson, G.H.4
-
22
-
-
67149094732
-
Convergence of IL-1 and VDR activation pathways in human TLR2/1-induced antimicrobial responses
-
[CrossRef] [PubMed]
-
Liu, P.T.; Schenk, M.; Walker, V.P.; Dempsey, P.W.; Kanchanapoomi, M.; Wheelwright, M.; Vazirnia, A.; Zhang, X.; Steinmeyer, A.; Zugel, U. et al. Convergence of IL-1 and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS ONE 2009, 4, e5810. [CrossRef] [PubMed]
-
(2009)
Plos ONE
, vol.4
-
-
Liu, P.T.1
Schenk, M.2
Walker, V.P.3
Dempsey, P.W.4
Kanchanapoomi, M.5
Wheelwright, M.6
Vazirnia, A.7
Zhang, X.8
Steinmeyer, A.9
Zugel, U.10
-
23
-
-
0035929603
-
1,25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase
-
[CrossRef] [PubMed]
-
Sly, L.M.; Lopez, M.; Nausseef, W.M.; Reiner, N.E. 1,25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase. J. Biol. Chem. 2001, 276, 35482–35493. [CrossRef] [PubMed]
-
(2001)
J. Biol. Chem
, vol.276
, pp. 35482-35493
-
-
Sly, L.M.1
Lopez, M.2
Nausseef, W.M.3
Reiner, N.E.4
-
24
-
-
78651077774
-
Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling
-
[CrossRef] [PubMed]
-
Shin, D.M.; Yuk, J.M.; Lee, H.M.; Lee, S.H.; Son, J.W.; Harding, C.V.; Kim, J.M.; Modlin, R.L.; Jo, E.K. Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling. Cell. Microbiol. 2010, 12, 1648–1665. [CrossRef] [PubMed]
-
(2010)
Cell. Microbiol
, vol.12
, pp. 1648-1665
-
-
Shin, D.M.1
Yuk, J.M.2
Lee, H.M.3
Lee, S.H.4
Son, J.W.5
Harding, C.V.6
Kim, J.M.7
Modlin, R.L.8
Jo, E.K.9
-
25
-
-
50249179101
-
Vitamin effects on the immune system: Vitamins A and D take centre stage
-
[CrossRef] [PubMed]
-
Mora, J.R.; Iwata, M.; von Andrian, U.H. Vitamin effects on the immune system: Vitamins A and D take centre stage. Nat. Rev. Immunol. 2008, 8, 685–698. [CrossRef] [PubMed]
-
(2008)
Nat. Rev. Immunol
, vol.8
, pp. 685-698
-
-
Mora, J.R.1
Iwata, M.2
Von Andrian, U.H.3
-
26
-
-
84901022347
-
Impact of vitamin D on immune function: Lessons learned from genome-wide analysis
-
[CrossRef] [PubMed]
-
Chun, R.F.; Liu, P.T.; Modlin, R.L.; Adams, J.S.; Hewison, M. Impact of vitamin D on immune function: Lessons learned from genome-wide analysis. Front. Physiol. 2014, 5. [CrossRef] [PubMed]
-
(2014)
Front. Physiol
, pp. 5
-
-
Chun, R.F.1
Liu, P.T.2
Modlin, R.L.3
Adams, J.S.4
Hewison, M.5
-
27
-
-
77957373318
-
Mechanisms underlying the effect of vitamin D on the immune system
-
[CrossRef] [PubMed]
-
Cantorna, M.T. Mechanisms underlying the effect of vitamin D on the immune system. Proc. Nutr. Soc. 2010, 69, 286–289. [CrossRef] [PubMed]
-
(2010)
Proc. Nutr. Soc
, vol.69
, pp. 286-289
-
-
Cantorna, M.T.1
-
28
-
-
0022256520
-
1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro
-
[PubMed]
-
Lemire, J.M.; Adams, J.S.; Kermani-Arab, V.; Bakke, A.C.; Sakai, R.; Jordan, S.C. 1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro. J. Immunol. 1985, 134, 3032–3035. [PubMed]
-
(1985)
J. Immunol
, vol.134
, pp. 3032-3035
-
-
Lemire, J.M.1
Adams, J.S.2
Kermani-Arab, V.3
Bakke, A.C.4
Sakai, R.5
Jordan, S.C.6
-
29
-
-
0029149894
-
Transcriptional repression of the interleukin-2 gene by vitamin D3: Direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor
-
[PubMed]
-
Alroy, I.; Towers, T.L.; Freedman, L.P. Transcriptional repression of the interleukin-2 gene by vitamin D3: Direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol. Cell. Biol. 1995, 15, 5789–5799. [PubMed]
-
(1995)
Mol. Cell. Biol
, vol.15
, pp. 5789-5799
-
-
Alroy, I.1
Towers, T.L.2
Freedman, L.P.3
-
30
-
-
80052387833
-
1,25-Dihydroxyvitamin D3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A
-
[CrossRef] [PubMed]
-
Joshi, S.; Pantalena, L.C.; Liu, X.K.; Gaffen, S.L.; Liu, H.; Rohowsky-Kochan, C.; Ichiyama, K.; Yoshimura, A.; Steinman, L.; Christakos, S. et al. 1,25-Dihydroxyvitamin D3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol. Cell. Biol. 2011, 31, 3653–3669. [CrossRef] [PubMed]
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 3653-3669
-
-
Joshi, S.1
Pantalena, L.C.2
Liu, X.K.3
Gaffen, S.L.4
Liu, H.5
Rohowsky-Kochan, C.6
Ichiyama, K.7
Yoshimura, A.8
Steinman, L.9
Christakos, S.10
-
31
-
-
0031595992
-
Vitamin D3: A transcriptional modulator of the interferon-gamma gene
-
[CrossRef]
-
Cippitelli, M.; Santoni, A. Vitamin D3: A transcriptional modulator of the interferon-gamma gene. Eur. J. Immunol. 1998, 28, 3017–3030. [CrossRef]
-
(1998)
Eur. J. Immunol
, vol.28
, pp. 3017-3030
-
-
Cippitelli, M.1
Santoni, A.2
-
32
-
-
84929377526
-
Vitamin D and 1,25(OH)2D regulation of T cells
-
[CrossRef] [PubMed]
-
Cantorna, M.T.; Snyder, L.; Lin, Y.D.; Yang, L. Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients 2015, 7, 3011–3021. [CrossRef] [PubMed]
-
(2015)
Nutrients
, vol.7
, pp. 3011-3021
-
-
Cantorna, M.T.1
Snyder, L.2
Lin, Y.D.3
Yang, L.4
-
33
-
-
84856250752
-
Vitamin D and immune function: An overview
-
[CrossRef] [PubMed]
-
Hewison, M. Vitamin D and immune function: An overview. Proc. Nutr. Soc. 2012, 71, 50–61. [CrossRef] [PubMed]
-
(2012)
Proc. Nutr. Soc
, vol.71
, pp. 50-61
-
-
Hewison, M.1
-
34
-
-
84907956794
-
Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease
-
[CrossRef] [PubMed]
-
Vasiliou, J.E.; Lui, S.; Walker, S.A.; Chohan, V.; Xystrakis, E.; Bush, A.; Hawrylowicz, C.M.; Saglani, S.; Lloyd, C.M. Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease. Allergy 2014, 69, 1380–1389. [CrossRef] [PubMed]
-
(2014)
Allergy
, vol.69
, pp. 1380-1389
-
-
Vasiliou, J.E.1
Lui, S.2
Walker, S.A.3
Chohan, V.4
Xystrakis, E.5
Bush, A.6
Hawrylowicz, C.M.7
Saglani, S.8
Lloyd, C.M.9
-
35
-
-
70449368149
-
Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD-L1
-
[CrossRef] [PubMed]
-
Unger, W. W.; Laban, S.; Kleijwegt, F.S.; van der Slik, A. R.; Roep, B.O. Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD-L1. Eur. J. Immunol. 2009, 39, 3147–3159. [CrossRef] [PubMed]
-
(2009)
Eur. J. Immunol
, vol.39
, pp. 3147-3159
-
-
Unger, W.W.1
Laban, S.2
Kleijwegt, F.S.3
Van Der Slik, A.R.4
Roep, B.O.5
-
36
-
-
84926621134
-
1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients
-
[CrossRef] [PubMed]
-
Van Belle, T.L.; Vanherwegen, A.S.; Feyaerts, D.; de Clercq, P.; Verstuyf, A.; Korf, H.; Gysemans, C.; Mathieu, C. 1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients. PLoS ONE 2014, 9, e109194. [CrossRef] [PubMed]
-
(2014)
Plos ONE
, vol.9
-
-
Van Belle, T.L.1
Vanherwegen, A.S.2
Feyaerts, D.3
De Clercq, P.4
Verstuyf, A.5
Korf, H.6
Gysemans, C.7
Mathieu, C.8
-
37
-
-
77951253745
-
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3
-
[CrossRef] [PubMed]
-
Jeffery, L.E.; Burke, F.; Mura, M.; Zheng, Y.; Qureshi, O.S.; Hewison, M.; Walker, L.S.; Lammas, D.A.; Raza, K.; Sansom, D.M. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J. Immunol. 2009, 183, 5458–5467. [CrossRef] [PubMed]
-
(2009)
J. Immunol
, vol.183
, pp. 5458-5467
-
-
Jeffery, L.E.1
Burke, F.2
Mura, M.3
Zheng, Y.4
Qureshi, O.S.5
Hewison, M.6
Walker, L.S.7
Lammas, D.A.8
Raza, K.9
Sansom, D.M.10
-
38
-
-
77958605267
-
1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of Th17 cells to protect against experimental autoimmune encephalomyelitis
-
[CrossRef] [PubMed]
-
Chang, J.H.; Cha, H.R.; Lee, D.S.; Seo, K.Y.; Kweon, M.N. 1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of Th17 cells to protect against experimental autoimmune encephalomyelitis. PLoS ONE 2010, 5, e12925. [CrossRef] [PubMed]
-
(2010)
Plos ONE
, vol.5
-
-
Chang, J.H.1
Cha, H.R.2
Lee, D.S.3
Seo, K.Y.4
Kweon, M.N.5
-
39
-
-
74849095189
-
1,25-Dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis
-
[CrossRef] [PubMed]
-
Colin, E.M.; Asmawidjaja, P.S.; van Hamburg, J.P.; Mus, A.M.; van Driel, M.; Hazes, J.M.; van Leeuwen, J.P.; Lubberts, E. 1,25-Dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum. 2010, 62, 132–142. [CrossRef] [PubMed]
-
(2010)
Arthritis Rheum
, vol.62
, pp. 132-142
-
-
Colin, E.M.1
Asmawidjaja, P.S.2
Van Hamburg, J.P.3
Mus, A.M.4
Van Driel, M.5
Hazes, J.M.6
Van Leeuwen, J.P.7
Lubberts, E.8
-
40
-
-
78651407519
-
Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells
-
[CrossRef] [PubMed]
-
Palmer, M.T.; Lee, Y.K.; Maynard, C.L.; Oliver, J.R.; Bikle, D.D.; Jetten, A.M.; Weaver, C.T. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J. Biol. Chem. 2011, 286, 997–1004. [CrossRef] [PubMed]
-
(2011)
J. Biol. Chem
, vol.286
, pp. 997-1004
-
-
Palmer, M.T.1
Lee, Y.K.2
Maynard, C.L.3
Oliver, J.R.4
Bikle, D.D.5
Jetten, A.M.6
Weaver, C.T.7
-
41
-
-
0034161714
-
1,25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation
-
[CrossRef] [PubMed]
-
Penna, G.; Adorini, L. 1,25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J. Immunol. 2000, 164, 2405–2411. [CrossRef] [PubMed]
-
(2000)
J. Immunol
, vol.164
, pp. 2405-2411
-
-
Penna, G.1
Adorini, L.2
-
42
-
-
0035811015
-
Dendritic cell modulation by 1,25-dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo
-
[CrossRef] [PubMed]
-
Griffin, M.D.; Lutz, W.; Phan, V.A.; Bachman, L.A.; McKean, D.J.; Kumar, R. Dendritic cell modulation by 1,25-dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc. Natl. Acad. Sci. USA 2001, 98, 6800–6805. [CrossRef] [PubMed]
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6800-6805
-
-
Griffin, M.D.1
Lutz, W.2
Phan, V.A.3
Bachman, L.A.4
McKean, D.J.5
Kumar, R.6
-
43
-
-
0034852081
-
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) hampers the maturation of fully active immature dendritic cells from monocytes
-
[CrossRef] [PubMed]
-
Canning, M.O.; Grotenhuis, K.; de Wit, H.; Ruwhof, C.; Drexhage, H.A. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) hampers the maturation of fully active immature dendritic cells from monocytes. Eur. J. Endocrinol. 2001, 145, 351–357. [CrossRef] [PubMed]
-
(2001)
Eur. J. Endocrinol
, vol.145
, pp. 351-357
-
-
Canning, M.O.1
Grotenhuis, K.2
De Wit, H.3
Ruwhof, C.4
Drexhage, H.A.5
-
44
-
-
0031974910
-
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene
-
[CrossRef] [PubMed]
-
D’Ambrosio, D.; Cippitelli, M.; Cocciolo, M.G.; Mazzeo, D.; di Lucia, P.; Lang, R.; Sinigaglia, F.; Panina-Bordignon, P. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J. Clin. Investig. 1998, 101, 252–262. [CrossRef] [PubMed]
-
(1998)
J. Clin. Investig
, vol.101
, pp. 252-262
-
-
D’Ambrosio, D.1
Cippitelli, M.2
Cocciolo, M.G.3
Mazzeo, D.4
Di Lucia, P.5
Lang, R.6
Sinigaglia, F.7
Panina-Bordignon, P.8
-
45
-
-
80052610245
-
Latitude is significantly associated with the prevalence of multiple sclerosis: A meta-analysis
-
[CrossRef] [PubMed]
-
Simpson, S.J.; Blizzard, L.; Otahal, P.; van der Mei, I.; Taylor, B. Latitude is significantly associated with the prevalence of multiple sclerosis: A meta-analysis. J. Neurol. Neurosurg. Psychiatry 2011, 82, 1132–1141. [CrossRef] [PubMed]
-
(2011)
J. Neurol. Neurosurg. Psychiatry
, vol.82
, pp. 1132-1141
-
-
Simpson, S.J.1
Blizzard, L.2
Otahal, P.3
Van Der Mei, I.4
Taylor, B.5
-
46
-
-
84901641094
-
Latitude, sunshine, and human lactase phenotype distributions may contribute to geographic patterns of modern disease: The inflammatory bowel disease model
-
[CrossRef] [PubMed]
-
Szilagyi, A.; Leighton, H.; Burstein, B.; Xue, X. Latitude, sunshine, and human lactase phenotype distributions may contribute to geographic patterns of modern disease: The inflammatory bowel disease model. Clin. Epidemiol. 2014, 6, 183–198. [CrossRef] [PubMed]
-
(2014)
Clin. Epidemiol
, vol.6
, pp. 183-198
-
-
Szilagyi, A.1
Leighton, H.2
Burstein, B.3
Xue, X.4
-
47
-
-
10044281540
-
Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence
-
[PubMed]
-
Cantorna, M.T.; Mahon, B.D. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp. Biol. Med. (Maywood) 2004, 229, 1136–1142. [PubMed]
-
(2004)
Exp. Biol. Med. (Maywood)
, vol.229
, pp. 1136-1142
-
-
Cantorna, M.T.1
Mahon, B.D.2
-
48
-
-
33845720114
-
Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
-
[CrossRef] [PubMed]
-
Munger, K.L.; Levin, L.I.; Hollis, B.W.; Howard, N.S.; Ascherio, A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006, 296, 2832–2838. [CrossRef] [PubMed]
-
(2006)
JAMA
, vol.296
, pp. 2832-2838
-
-
Munger, K.L.1
Levin, L.I.2
Hollis, B.W.3
Howard, N.S.4
Ascherio, A.5
-
49
-
-
79955653072
-
Deficiency in patients with inflammatory bowel disease: Association with disease activity and quality of life
-
[CrossRef] [PubMed]
-
Ulitsky, A.; Ananthakrishnan, A.N.; Naik, A.; Skaros, S.; Zadvornova, Y.; Binion, D.G.; Issa, M. Vitamin D deficiency in patients with inflammatory bowel disease: Association with disease activity and quality of life. JPEN J. Parenter. Enter. Nutr. 2011, 35, 308–316. [CrossRef] [PubMed]
-
(2011)
JPEN J. Parenter. Enter. Nutr
, vol.35
, pp. 308-316
-
-
Ulitsky, A.1
Ananthakrishnan, A.N.2
Naik, A.3
Skaros, S.4
Zadvornova, Y.5
Binion, D.G.6
Issa, M.7
Vitamin, D.8
-
50
-
-
0021342529
-
Prevention of experimental allergic encephalomyelitis (EAE) in the SJL/J mouse by whole body ultraviolet irradiation
-
[PubMed]
-
Hauser, S.L.; Weiner, H.L.; Che, M.; Shapiro, M.E.; Gilles, F.; Letvin, N.L. Prevention of experimental allergic encephalomyelitis (EAE) in the SJL/J mouse by whole body ultraviolet irradiation. J. Immunol. 1984, 132, 1276–1281. [PubMed]
-
(1984)
J. Immunol
, vol.132
, pp. 1276-1281
-
-
Hauser, S.L.1
Weiner, H.L.2
Che, M.3
Shapiro, M.E.4
Gilles, F.5
Letvin, N.L.6
-
51
-
-
77950910418
-
Radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production
-
[CrossRef] [PubMed]
-
Becklund, B.R.; Severson, K.S.; Vang, S.V.; DeLuca, H.F. UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production. Proc. Natl. Acad. Sci. USA 2010, 107, 6418–6423. [CrossRef] [PubMed]
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 6418-6423
-
-
Becklund, B.R.1
Severson, K.S.2
Vang, S.V.3
Deluca, H.4
-
52
-
-
0025732356
-
1,25-Dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis
-
[CrossRef] [PubMed]
-
Lemire, J.M.; Archer, D.C. 1,25-Dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis. J. Clin. Investig. 1991, 87, 1103–1107. [CrossRef] [PubMed]
-
(1991)
J. Clin. Investig
, vol.87
, pp. 1103-1107
-
-
Lemire, J.M.1
Archer, D.C.2
-
53
-
-
0029821239
-
1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
-
[CrossRef] [PubMed]
-
Cantorna, M.T.; Hayes, C.E.; DeLuca, H.F. 1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc. Natl. Acad. Sci. USA 1996, 93, 7861–7864. [CrossRef] [PubMed]
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7861-7864
-
-
Cantorna, M.T.1
Hayes, C.E.2
Deluca, H.F.3
-
54
-
-
0032702846
-
Dietary calcium is a major factor in 1,25-dihydroxycholecalciferol suppression of experimental autoimmune encephalomyelitis in mice
-
[PubMed]
-
Cantorna, M.T.; Humpal-Winter, J.; DeLuca, H.F. Dietary calcium is a major factor in 1,25-dihydroxycholecalciferol suppression of experimental autoimmune encephalomyelitis in mice. J. Nutr. 1999, 129, 1966–1971. [PubMed]
-
(1999)
J. Nutr
, vol.129
, pp. 1966-1971
-
-
Cantorna, M.T.1
Humpal-Winter, J.2
Deluca, H.F.3
-
55
-
-
0033975024
-
Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D3
-
[CrossRef]
-
Mattner, F.; Smiroldo, S.; Galbiati, F.; Muller, M.; di Lucia, P.; Poliani, P.L.; Martino, G.; Panina-Bordignon, P.; Adorini, L. Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D3. Eur. J. Immunol. 2000, 30, 498–508. [CrossRef]
-
(2000)
Eur. J. Immunol
, vol.30
, pp. 498-508
-
-
Mattner, F.1
Smiroldo, S.2
Galbiati, F.3
Muller, M.4
Di Lucia, P.5
Poliani, P.L.6
Martino, G.7
Panina-Bordignon, P.8
Adorini, L.9
-
56
-
-
33750314525
-
IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis
-
[CrossRef] [PubMed]
-
Spach, K.M.; Nashold, F.E.; Dittel, B.N.; Hayes, C.E. IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J. Immunol. 2006, 177, 6030–6037. [CrossRef] [PubMed]
-
(2006)
J. Immunol
, vol.177
, pp. 6030-6037
-
-
Spach, K.M.1
Nashold, F.E.2
Dittel, B.N.3
Hayes, C.E.4
-
57
-
-
84861575039
-
Vitamin D, multiple sclerosis and inflammatory bowel disease
-
[CrossRef] [PubMed]
-
Cantorna, M.T. Vitamin D, multiple sclerosis and inflammatory bowel disease. Arch. Biochem. Biophys. 2012, 523, 103–106. [CrossRef] [PubMed]
-
(2012)
Arch. Biochem. Biophys
, vol.523
, pp. 103-106
-
-
Cantorna, M.T.1
-
58
-
-
0036919768
-
The vitamin D receptor is necessary for 1,25-dihydroxyvitamin D to suppress experimental autoimmune encepthalomyelitis in mice
-
[CrossRef]
-
Meehan, T.F.; DeLuca, H.F. The vitamin D receptor is necessary for 1,25-dihydroxyvitamin D to suppress experimental autoimmune encepthalomyelitis in mice. Arch. Biochem. Biophys. 2002, 408, 200–204. [CrossRef]
-
(2002)
Arch. Biochem. Biophys
, vol.408
, pp. 200-204
-
-
Meehan, T.F.1
Deluca, H.F.2
-
59
-
-
84861881222
-
Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor
-
[CrossRef] [PubMed]
-
Wang, Y.; Marling, S.J.; Zhu, J.G.; Severson, K.S.; DeLuca, H.F. Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor. Proc. Natl. Acad. Sci. USA 2013, 109, 8501–8504. [CrossRef] [PubMed]
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 8501-8504
-
-
Wang, Y.1
Marling, S.J.2
Zhu, J.G.3
Severson, K.S.4
Deluca, H.F.5
-
60
-
-
34247282706
-
VitaminDand the vitaminDreceptor are critical for control of the innate immune response to colonic injury
-
[CrossRef] [PubMed]
-
Froicu, M.; Cantorna, M.T. VitaminDand the vitaminDreceptor are critical for control of the innate immune response to colonic injury. BMC Immunol. 2007, 8. [CrossRef] [PubMed]
-
(2007)
BMC Immunol
, pp. 8
-
-
Froicu, M.1
Cantorna, M.T.2
-
61
-
-
0029918501
-
Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: Effects in CD4(+)-cell depleted, athymic and NK-cell depleted SCID mice
-
[CrossRef] [PubMed]
-
Axelsson, L.G.; Landstrom, E.; Goldschmidt, T.J.; Gronberg, A.; Bylund-Fellenius, A.C. Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: Effects in CD4(+)-cell depleted, athymic and NK-cell depleted SCID mice. Inflamm. Res. 1996, 45, 181–191. [CrossRef] [PubMed]
-
(1996)
Inflamm. Res
, vol.45
, pp. 181-191
-
-
Axelsson, L.G.1
Landstrom, E.2
Goldschmidt, T.J.3
Gronberg, A.4
Bylund-Fellenius, A.C.5
-
62
-
-
84894898256
-
Transgenic expression of the vitamin D receptor (VDR) restricted to the ileum, cecum and colon of VDR knockout mice rescues VDR dependent rickets
-
Dhawan, P.; Hsaio, C.; Yehia, G.; Porta, A.; Lieben, L.; Carmeliet, G.; Christakos, S. Transgenic expression of the vitamin D receptor (VDR) restricted to the ileum, cecum and colon of VDR knockout mice rescues VDR dependent rickets. J. Bone Min. Res. 2012, 27 (Suppl. S1), S34.
-
(2012)
J. Bone Min. Res
, vol.27
-
-
Dhawan, P.1
Hsaio, C.2
Yehia, G.3
Porta, A.4
Lieben, L.5
Carmeliet, G.6
Christakos, S.7
-
63
-
-
85018070331
-
Studies in mice with transgenic expression of the vitamin D receptor (VDR) exclusively in the distal intestine of VDR knockout mice provide evidence for a critical role of intestinal epithelial cells in the suppression of inflammatory bowel disease by 1,25(OH)2D3/VDR
-
Wei, R.; Dhawan, P.; Christakos, S. Studies in mice with transgenic expression of the vitamin D receptor (VDR) exclusively in the distal intestine of VDR knockout mice provide evidence for a critical role of intestinal epithelial cells in the suppression of inflammatory bowel disease by 1,25(OH)2D3/VDR. J. Bone Min. Res. 2013, 28 (Suppl. S1), S329.
-
(2013)
J. Bone Min. Res
, vol.28
-
-
Wei, R.1
Dhawan, P.2
Christakos, S.3
-
64
-
-
35448972047
-
Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation
-
[CrossRef] [PubMed]
-
Hinoi, T.; Akyol, A.; Theisen, B.K.; Ferguson, D.O.; Greenson, J.K.; Williams, B.O.; Cho, K.R.; Fearon, E.R. Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation. Cancer Res. 2007, 67, 9721–9730. [CrossRef] [PubMed]
-
(2007)
Cancer Res
, vol.67
, pp. 9721-9730
-
-
Hinoi, T.1
Akyol, A.2
Theisen, B.K.3
Ferguson, D.O.4
Greenson, J.K.5
Williams, B.O.6
Cho, K.R.7
Fearon, E.R.8
-
65
-
-
84880656935
-
Vitamin D biology revealed through the study of knockout and transgenic mouse models
-
[CrossRef] [PubMed]
-
Christakos, S.; Seth, T.; Hirsch, J.; Porta, A.; Moulas, A.; Dhawan, P. Vitamin D biology revealed through the study of knockout and transgenic mouse models. Annu. Rev. Nutr. 2013, 33, 71–85. [CrossRef] [PubMed]
-
(2013)
Annu. Rev. Nutr
, vol.33
, pp. 71-85
-
-
Christakos, S.1
Seth, T.2
Hirsch, J.3
Porta, A.4
Moulas, A.5
Dhawan, P.6
-
66
-
-
67749088132
-
Supplemental calcium attenuates the colitis-related increase in diarrhea, intestinal permeability, and extracellular matrix breakdown in HLA-B27 transgenic rats
-
[CrossRef] [PubMed]
-
Schepens, M.A.; Schonewille, A.J.; Vinck, C.; van Schothorst, E.M.; Kramer, E.; Hendriks, T.; Brummer, R.J.; Keijer, J.; van der Meer, R.; Bovee-Oudenhoven, I.M. Supplemental calcium attenuates the colitis-related increase in diarrhea, intestinal permeability, and extracellular matrix breakdown in HLA-B27 transgenic rats. J. Nutr. 2009, 139, 1525–1533. [CrossRef] [PubMed]
-
(2009)
J. Nutr
, vol.139
, pp. 1525-1533
-
-
Schepens, M.A.1
Schonewille, A.J.2
Vinck, C.3
Van Schothorst, E.M.4
Kramer, E.5
Hendriks, T.6
Brummer, R.J.7
Keijer, J.8
Van Der Meer, R.9
Bovee-Oudenhoven, I.M.10
-
67
-
-
84885693359
-
Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced colitis
-
[CrossRef] [PubMed]
-
Ooi, J.H.; Li, Y.; Rogers, C.J.; Cantorna, M.T. Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced colitis. J. Nutr. 2013, 143, 1679–1686. [CrossRef] [PubMed]
-
(2013)
J. Nutr
, vol.143
, pp. 1679-1686
-
-
Ooi, J.H.1
Li, Y.2
Rogers, C.J.3
Cantorna, M.T.4
-
68
-
-
84883503073
-
Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis
-
[CrossRef] [PubMed]
-
Liu, W.; Chen, Y.; Golan, M.A.; Annunziata, M.L.; Du, J.; Dougherty, U.; Kong, J.; Musch, M.; Huang, Y.; Pekow, J. et al. Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J. Clin. Investig. 2013, 123, 3983–3996. [CrossRef] [PubMed]
-
(2013)
J. Clin. Investig
, vol.123
, pp. 3983-3996
-
-
Liu, W.1
Chen, Y.2
Golan, M.A.3
Annunziata, M.L.4
Du, J.5
Dougherty, U.6
Kong, J.7
Musch, M.8
Huang, Y.9
Pekow, J.10
-
69
-
-
84873977493
-
Antimicrobial peptides and colitis. Curr
-
[PubMed]
-
Ho, S.; Pothoulakis, C.; Koon, H.W. Antimicrobial peptides and colitis. Curr. Pharm. Des. 2013, 19, 40–47. [PubMed]
-
(2013)
Pharm. Des
, vol.19
, pp. 40-47
-
-
Ho, S.1
Pothoulakis, C.2
Koon, H.W.3
|