Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis

Kidney International

Volumn 89, Issue 1, 2016, Pages 127-134

  Terker, Andrew S ^a   Zhang, Chong ^b   Erspamer, Kayla J ^a   Gamba, Gerardo ^c   Yang, Chao Ling ^a,d   Ellison, David H ^a,d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

cell signaling; distal convoluted tubule; mineral metabolism; potassium channels; thiazide sensitive NaCl cotransporter

Indexed keywords

CHLORIDE; POTASSIUM ION; PROTEIN KINASE WNK1; PROTEIN KINASE WNK3; PROTEIN KINASE WNK4; PROTEIN SERINE THREONINE KINASE; SODIUM CHLORIDE COTRANSPORTER; UNCLASSIFIED DRUG; MINOR HISTOCOMPATIBILITY ANTIGEN; POTASSIUM; POTASSIUM INTAKE; PRKWNK4 PROTEIN, MOUSE; SIGNAL PEPTIDE; STK39 PROTEIN, HUMAN; STK39 PROTEIN, MOUSE; WNK1 PROTEIN, HUMAN; WNK1 PROTEIN, MOUSE; WNK3 PROTEIN, HUMAN; WNK3 PROTEIN, MOUSE; WNK4 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME INHIBITION; HEK293 CELL LINE; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEPHRON; NONHUMAN; OOCYTE; POTASSIUM BLOOD LEVEL; POTASSIUM HOMEOSTASIS; PRIORITY JOURNAL; XENOPUS; ADMINISTRATION AND DOSAGE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; C57BL MOUSE; CYTOLOGY; GENETICS; KIDNEY DISTAL TUBULE; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; POTASSIUM INTAKE;

ANIMALS; CHLORIDES; HEK293 CELLS; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY TUBULES, DISTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MINOR HISTOCOMPATIBILITY ANTIGENS; MUTATION; NEPHRONS; PHOSPHORYLATION; POTASSIUM; POTASSIUM, DIETARY; PROTEIN-SERINE-THREONINE KINASES; SOLUTE CARRIER FAMILY 12, MEMBER 3;

EID: 84942645605     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2015.289     Document Type: Article

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