Immunolocalization of WNK4 in mouse kidney

Histochemistry and Cell Biology

Volumn 136, Issue 1, 2011, Pages 25-35

  Ohno, Mayuko ^a   Uchida, Keiko ^a   Ohashi, Teiko ^a   Nitta, Kosaku ^a   Ohta, Akihito ^b   Chiga, Motoko ^b   Sasaki, Sei ^b   Uchida, Shinichi ^b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

AQP2 water channel; Immunoelectron microscopy; Immunofluorescence; Na Cl co transporter; WNK kinase

Indexed keywords

PROTEIN KINASE WNK4;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CELLULAR DISTRIBUTION; ENZYME LOCALIZATION; GLOMERULUS; HENLE LOOP; IMMUNOFLUORESCENCE; IMMUNOLOCALIZATION; KIDNEY; KIDNEY COLLECTING TUBULE; KIDNEY CORTEX; KIDNEY DISTAL TUBULE; KIDNEY MEDULLA; MOUSE; NEPHRON; NONHUMAN; PODOCYTE; PRIORITY JOURNAL;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; FLUORESCENT ANTIBODY TECHNIQUE; KIDNEY; KIDNEY TUBULES, DISTAL; MICE; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, DRUG; SYMPORTERS;

EID: 79960277897     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-011-0827-x     Document Type: Article

References (25)

1. M Chiga T Rai SS Yang A Ohta T Takizawa S Sasaki S Uchida 2008 Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone Kidney Int 74 1403 1409 18800028 10.1038/ki.2008.451 1:CAS:528:DC%2BD1cXhtlOjtrrP
2. C Delaloy E Elvira-Matelot M Clemessy XO Zhou M Imbert-Teboul AM Houot X Jeunemaitre J Hadchouel 2008 Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues Hypertension 52 1149 1154 18955660 10.1161/HYPERTENSIONAHA.108.120899 1:CAS:528: DC%2BD1cXhsVWrt7vI
3. K Fushimi S Uchida Y Hara Y Hirata F Marumo S Sasaki 1993 Cloning and expression of apical membrane water channel of rat kidney collecting tubule Nature 361 549 552 8429910 10.1038/361549a0 1:CAS:528:DyaK3sXisFSjsrk%3D (Pubitemid 23055619)
4. RD Gordon 1986 Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate Hypertension 8 93 102 3002982 1:STN:280: DyaL287htVGiug%3D%3D (Pubitemid 16105215)
5. Y Jiang WB Ferguson JB Peng 2007 WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4 Am J Physiol Renal Physiol 292 F545 F554 17018846 10.1152/ajprenal.00187.2006 1:CAS:528:DC%2BD2sXjt1GmsLc%3D (Pubitemid 46220521)
6. KT Kahle FH Wilson Q Leng MD Lalioti AD O'Connell K Dong AK Rapson GG MacGregor G Giebisch SC Hebert RP Lifton 2003 WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion Nat Genet 35 372 376 14608358 10.1038/ng1271 1:CAS:528:DC%2BD3sXpt1Ciu7g%3D (Pubitemid 37486922)
7. KT Kahle I Gimenez H Hassan FH Wilson RD Wong B Forbush PS Aronson RP Lifton 2004 WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia Proc Natl Acad Sci USA 101 2064 2069 14769928 10.1073/pnas.0308434100 1:CAS:528:DC%2BD2cXhs1Srsr8%3D (Pubitemid 38229015)
8. KT Kahle GG Macgregor FH Wilson AN Van Hoek D Brown T Ardito M Kashgarian G Giebisch SC Hebert EL Boulpaep RP Lifton 2004 Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension Proc Natl Acad Sci USA 101 14877 14882 15465913 10.1073/pnas.0406172101 1:CAS:528:DC%2BD2cXovVyisrk%3D (Pubitemid 39410768)
9. MR Kaplan MD Plotkin WS Lee ZC Xu J Lytton SC Hebert 1996 Apical localization of the Na-K-Cl cotransporter, rBSC1, on rat thick ascending limbs Kidney Int 49 40 47 8770947 10.1038/ki.1996.6 1:CAS:528:DyaK28Xht1amtr8%3D (Pubitemid 26022826)
10. Kriz W, Kaissling B (1985) Structural organization of the mammalian kidney. In: Seldin DW, Giebish G (eds) The Kidney: physiology and pathophysiology, vol 1. Raven Press, New York, pp 265-306
11. J Loffing D Loffing-Cueni V Valderrabano L Klausli SC Hebert BC Rossier JG Hoenderop RJ Bindels B Kaissling 2001 Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron Am J Physiol Renal Physiol 281 F1021 F1027 11704552 1:CAS:528:DC%2BD3MXptlKntbc%3D
12. K Mutig T Saritas S Uchida T Kahl T Borowski A Paliege A Bohlick M Bleich Q Shan S Bachmann 2010 Short-term stimulation of the thiazide-sensitive Na+-Cl- cotransporter by vasopressin involves phosphorylation and membrane translocation Am J Physiol Renal Physiol 298 F502 F509 20007345 10.1152/ajprenal.00476.2009 1:CAS:528:DC%2BC3cXjsFGntLY%3D
13. A Ohta T Rai N Yui M Chiga SS Yang SH Lin E Sohara S Sasaki S Uchida 2009 Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure Hum Mol Genet 18 3978 3986 19633012 10.1093/hmg/ddp344 1:CAS:528:DC%2BD1MXhtFyhu77M
14. M O'Reilly E Marshall HJ Speirs RW Brown 2003 WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain J Am Soc Nephrol 14 2447 2456 14514722 10.1097/01.ASN.0000089830.97681.3B (Pubitemid 37169330)
15. M O'Reilly E Marshall T Macgillivray M Mittal W Xue CJ Kenyon RW Brown 2006 Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo J Am Soc Nephrol 17 2402 2413 16899520 10.1681/ASN.2005111197 (Pubitemid 44300956)
16. FH Rafiqi AM Zuber M Glover C Richardson S Fleming S Jovanovic A Jovanovic KM O'Shaughnessy DR Alessi 2010 Role of the WNK-activated SPAK kinase in regulating blood pressure EMBO Mol Med 2 63 75 20091762 10.1002/emmm. 200900058 1:CAS:528:DC%2BC3cXitlCjurY%3D
17. J Reiche F Theilig FH Rafiqi AS Carlo D Militz K Mutig M Todiras EI Christensen DH Ellison M Bader A Nykjaer S Bachmann D Alessi TE Willnow 2010 SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2 Mol Cell Biol 30 3027 3037 20385770 10.1128/MCB.01560-09 1:CAS:528:DC%2BC3cXotFGqsL4%3D
18. AM Ring SX Cheng Q Leng KT Kahle J Rinehart MD Lalioti HM Volkman FH Wilson SC Hebert RP Lifton 2007 WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo Proc Natl Acad Sci USA 104 4020 4024 17360470 10.1073/pnas.0611727104 1:CAS:528:DC%2BD2sXjt12is70%3D (Pubitemid 47181571)
19. AM Ring Q Leng J Rinehart FH Wilson KT Kahle SC Hebert RP Lifton 2007 An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis Proc Natl Acad Sci USA 104 4025 4029 17360471 10.1073/pnas.0611728104 1:CAS:528:DC%2BD2sXjt12hs7w%3D (Pubitemid 47181572)
20. L Schild Y Lu I Gautschi E Schneeberger RP Lifton BC Rossier 1996 Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome EMBO J 15 2381 2387 8665845 1:CAS:528:DyaK28XjsVGjur4%3D (Pubitemid 26156563)
21. FH Wilson S Disse-Nicodeme KA Choate K Ishikawa C Nelson-Williams I Desitter M Gunel DV Milford GW Lipkin JM Achard MP Feely B Dussol Y Berland RJ Unwin H Mayan DB Simon Z Farfel X Jeunemaitre RP Lifton 2001 Human hypertension caused by mutations in WNK kinases Science 293 1107 1112 11498583 10.1126/science.1062844 1:CAS:528:DC%2BD3MXmtVWrsrw%3D (Pubitemid 32758085)
22. K Yamauchi T Rai K Kobayashi E Sohara T Suzuki T Itoh S Suda A Hayama S Sasaki S Uchida 2004 Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins Proc Natl Acad Sci USA 101 4690 4694 15070779 10.1073/pnas.0306924101 1:CAS:528:DC%2BD2cXjtFKisbs%3D (Pubitemid 38437472)
23. CL Yang J Angell R Mitchell DH Ellison 2003 WNK kinases regulate thiazide-sensitive Na-Cl cotransport J Clin Invest 111 1039 1045 12671053 1:CAS:528:DC%2BD3sXislOgtr0%3D (Pubitemid 36397480)
24. CL Yang X Liu A Paliege X Zhu S Bachmann DC Dawson DH Ellison 2007 WNK1 and WNK4 modulate CFTR activity Biochem Biophys Res Commun 353 535 540 17194447 10.1016/j.bbrc.2006.11.151 1:CAS:528:DC%2BD2sXmtVajsg%3D%3D (Pubitemid 46048702)
25. SS Yang T Morimoto T Rai M Chiga E Sohara M Ohno K Uchida SH Lin T Moriguchi H Shibuya Y Kondo S Sasaki S Uchida 2007 Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model Cell Metab 5 331 344 17488636 10.1016/j.cmet.2007.03.009 1:CAS:528:DC%2BD2sXmt1Wqu74%3D (Pubitemid 46679517)