The fate of L5-S1 with low-dose BMP-2 and pelvic fixation, with or without interbody fusion, in adult deformity surgery

Spine

Volumn 40, Issue 11, 2015, Pages E634-E639

  Annis, Prokopis ^a   Brodke, Darrel S ^a   Spiker, William R ^a   Daubs, Michael D ^b   Lawrence, Brandon D ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEVADA   (United States)

Author keywords

Interbody fusion; Lumbosacral fixation; Pelvic fixation; Pseudarthrosis at L5 S1; rhBMP 2

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BMP2 PROTEIN, HUMAN;

ADULT; AGED; ALLOGRAFT; ARTICLE; AUTOGRAFT; BONE IMPLANT; BONE RADIOGRAPHY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; FOLLOW UP; HUMAN; LOW DRUG DOSE; LUMBOSACRAL SPINE; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE COMPLICATION; PELVIS SURGERY; PRIORITY JOURNAL; PSEUDARTHROSIS; RETROSPECTIVE STUDY; SACRUM; SPINE FUSION; SPINE MALFORMATION; SURGICAL APPROACH; ADVERSE EFFECTS; DEVICES; INTERNAL FIXATOR; LUMBAR VERTEBRA; MIDDLE AGED; PROCEDURES; RADIOGRAPHY; REOPERATION; SCOLIOSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BONE MORPHOGENETIC PROTEIN 2; FEMALE; HUMANS; INTERNAL FIXATORS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; PSEUDARTHROSIS; REOPERATION; RETROSPECTIVE STUDIES; SACRUM; SCOLIOSIS; SPINAL FUSION;

EID: 84942605322     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0000000000000867     Document Type: Article

References (53)

1. Finger T, Bayerl S, Onken J, et al. Sacropelvic fixation versus fusion to the sacrum for spondylodesis in multilevel degenerative spine disease. Eur Spine J 2014; 23: 1013-20.
2. Edwards CC II, Bridwell KH, Patel A, et al. Long adult deformity fusions to L5 and the sacrum. A matched cohort analysis. Spine 2004; 29: 1996-2005.
3. Leong JC, Lu WW, Zheng Y, et al. Comparison of the strengths of lumbosacral fixation achieved with techniques using one and two triangulated sacral screws. Spine 1998; 23: 2289-94.
4. Kim YJ, Bridwell KH, Lenke LG, et al. Pseudarthrosis in primary fusions for adult idiopathic scoliosis: incidence, risk factors, and outcome analysis. Spine 2005; 30: 468-74.
5. Alegre GM, Gupta MC, Bay BK, et al. S1 screw bending moment with posterior spinal instrumentation across the lumbosa-cral junction after unilateral iliac crest harvest. Spine 2001; 26: 1950-5.
6. Allen BL Jr, Ferguson RL. The Galveston technique of pelvic fixation with L-rod instrumentation of the spine. Spine 1984; 9: 388-94.
7. Cunningham BW, Lewis SJ, Long J, et al. Biomechanical evaluation of lumbosacral reconstruction techniques for spondylolisthesis: an in vitro porcine model. Spine 2002; 27: 2321-7.
8. Jackson RP, McManus AC. The iliac buttress. A computed tomo-graphic study of sacral anatomy. Spine 1993; 18: 1318-28.
9. O'Brien JR, Yu W, Kaufman BE, et al. Biomechanical evaluation of S2 alar-iliac screws: effect of length and quad-cortical purchase as compared with iliac fixation. Spine 2013; 38: E1250-5.
10. Kuklo TR, Bridwell KH, Lewis SJ, et al. Minimum 2-year analysis of sacropelvic fixation and L5-S1 fusion using S1 and iliac screws. Spine 2001; 26: 1976-83.
11. Tsuchiya K, Bridwell KH, Kuklo TR, et al. Minimum 5-year analysis of L5-S1 fusion using sacropelvic fixation (bilateral S1 and iliac screws) for spinal deformity. Spine 2006; 31: 303-8.
12. Hsieh PC, Koski TR, O'Shaughnessy BA, et al. Anterior lumbar interbody fusion in comparison with transforaminal lumbar inter-body fusion: implications for the restoration of foraminal height, local disc angle, lumbar lordosis, and sagittal balance. J Neurosurg Spine 2007; 7: 379-86.
13. Jagannathan J, Sansur CA, Oskouian RJ Jr, et al. Radiographic restoration of lumbar alignment after transforaminal lumbar inter-body fusion. Neurosurgery 2009; 64: 955-63; discussion 63-4.
14. Kepler CK, Rihn JA, Radcliff KE, et al. Restoration of lordosis and disk height after single-level transforaminal lumbar interbody fusion. Orthop Surg 2012; 4: 15-20.
15. Kim SB, Jeon TS, Heo YM, et al. Radiographic results of single level transforaminal lumbar interbody fusion in degenerative lumbar spine disease: focusing on changes of segmental lordosis in fusion segment. Clin Orthop Surg 2009; 1: 207-13.
16. Buttermann GR, Glazer PA, Hu SS, et al. Anterior and posterior allografts in symptomatic thoracolumbar deformity. J Spinal Dis-ord 2001; 14: 54-66.
17. Lippman CR, Spence CA, Youssef AS, et al. Correction of adult sco-liosis via a posterior-only approach. Neurosurg Focus 2003; 14: e5.
18. Cho KJ, Suk SI, Park SR, et al. Short fusion versus long fusion for degenerative lumbar scoliosis. Eur Spine J 2008; 17: 650-6.
19. Weistroffer JK, Perra JH, Lonstein JE, et al. Complications in long fusions to the sacrum for adult scoliosis: minimum five-year analysis of fifty patients. Spine 2008; 33: 1478-83.
20. Crandall DG, Revella J. Transforaminal lumbar interbody fusion versus anterior lumbar interbody fusion as an adjunct to posterior instrumented correction of degenerative lumbar scoliosis: three year clinical and radiographic outcomes. Spine 2009; 34: 2126-33.
21. Dimar JR, Glassman SD, Burkus KJ, et al. Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. Spine 2006; 31: 2534-9; discussion 40.
22. Glassman SD, Dimar JR III, Burkus K, et al. The efficacy of rhBMP-2 for posterolateral lumbar fusion in smokers. Spine 2007; 32: 1693-8.
23. Luhmann SJ, Bridwell KH, Cheng I, et al. Use of bone mor-phogenetic protein-2 for adult spinal deformity. Spine 2005; 30: S110-7.
24. Rahman RK, Buchowski JM, Stephens B, et al. Comparison of TLIF with rhBMP-2 versus no TLIF and higher posterolateral rhBMP-2 dose at L5-S1 for long fusions to the sacrum with sacropelvic fixation in patients with primary adult deformity. Spine 2013; 38: 2264-71.
25. Lenke LG, Bridwell KH, Bullis D, et al. Results of in situ fusion for isthmic spondylolisthesis. J Spinal Disord 1992; 5: 433-42.
26. Brantigan JW, Steffee AD. A carbon fiber implant to aid interbody lumbar fusion. Two-year clinical results in the first 26 patients. Spine 1993; 18: 2106-7.
27. Pateder DB, Park YS, Kebaish KM, et al. Spinal fusion after revision surgery for pseudarthrosis in adult scoliosis. Spine 2006; 31: E314-9.
28. Bernhardt M, Swartz DE, Clothiaux PL, et al. Posterolateral lumbar and lumbosacral fusion with and without pedicle screw internal fixation. Clin Orthop Relat Res 1992;284: 109-15.
29. Horowitch A, Peek RD, Thomas JC Jr, et al. The Wiltse pedicle screw fixation system. Early clinical results. Spine 1989; 14: 461-7.
30. Molinari R W, Bridwell KH, Lenke LG, et al. Complications in the surgical treatment of pediatric high-grade, isthmic dysplastic spon-dylolisthesis. A comparison of three surgical approaches. Spine 1999; 24: 1701-11.
31. Lebwohl NH, Cunningham BW, Dmitriev A, et al. Biomechani-cal comparison of lumbosacral fixation techniques in a calf spine model. Spine 2002; 27: 2312-20.
32. McCord DH, Cunningham BW, Shono Y, et al. Biome-chanical analysis of lumbosacral fixation. Spine 1992; 17: S235-43.
33. Harimaya K, Mishiro T, Lenke LG, et al. Etiology and revision surgical strategies in failed lumbosacral fixation of adult spinal deformity constructs. Spine 2011; 36: 1701-10.
34. Glassman SD, Carreon L, Djurasovic M, et al. Posterolateral lumbar spine fusion with INFUSE bone graft. Spine J 2007; 7: 44-9.
35. Mulconrey DS, Bridwell KH, Flynn J, et al. Bone morphogenetic protein (RhBMP-2) as a substitute for iliac crest bone graft in multilevel adult spinal deformity surgery: minimum two-year evaluation of fusion. Spine 2008; 33: 2153-9.
36. Maeda T, Buchowski JM, Kim YJ, et al. Long adult spinal deformity fusion to the sacrum using rhBMP-2 versus autogenous iliac crest bone graft. Spine 2009; 34: 2205-12.
37. Carragee EJ, Chu G, Rohatgi R, et al. Cancer risk after use of recombinant bone morphogenetic protein-2 for spinal arthrodesis. J Bone Joint Surg Am 2013; 95: 1537-45.
38. Carragee EJ, Hurwitz EL, Weiner BK. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J 2011; 11: 471-91.
39. Boden SD, Zdeblick TA, Sandhu HS, et al. The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduc-tion in humans: a preliminary report. Spine 2000; 25: 376-81.
40. Haid R W Jr, Branch CL Jr, Alexander JT, et al. Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages. Spine J 2004; 4: 527-38; discussion 38-9.
41. Meisel HJ, Schnoring M, Hohaus C, et al. Posterior lumbar inter-body fusion using rhBMP-2. Eur Spine J 2008; 17: 1735-44.
42. Mummaneni PV, Pan J, Haid RW, et al. Contribution of recom-binant human bone morphogenetic protein-2 to the rapid creation of interbody fusion when used in transforaminal lumbar interbody fusion: a preliminary report. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004. J Neurosurg Spine 2004; 1: 19-23.
43. Shimer AL, Oner FC, Vaccaro AR. Spinal reconstruction and bone morphogenetic proteins: open questions. Injury 2009; 40 (suppl 3): S32-8.
44. Joseph V, Rampersaud YR. Heterotopic bone formation with the use of rhBMP2 in posterior minimal access interbody fusion: a CT analysis. Spine 2007; 32: 2885-90.
45. Chen NF, Smith ZA, Stiner E, et al. Symptomatic ectopic bone formation after off-label use of recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion. J Neu-rosurg Spine 2010; 12: 40-6.
46. Rihn JA, Patel R, Makda J, et al. Complications associated with single-level transforaminal lumbar interbody fusion. Spine J 2009; 9: 623-9.
47. Wong DA, Kumar A, Jatana S, et al. Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF/TLIF use of bone morphogenetic protein-2 (BMP-2). Spine J 2008; 8: 1011-8.
48. McClellan JW, Mulconrey DS, Forbes RJ, et al. Vertebral bone resorption after transforaminal lumbar interbody fusion with bone morphogenetic protein (rhBMP-2). J Spinal Disord Tech 2006; 19: 483-6.
49. Vaidya R, Sethi A, Bartol S, et al. Complications in the use of rhBMP-2 in PEEK cages for interbody spinal fusions. J Spinal Dis-ord Tech 2008; 21: 557-62.
50. Mindea SA, Shih P, Song JK. Recombinant human bone morpho-genetic protein-2-induced radiculitis in elective minimally invasive transforaminal lumbar interbody fusions: a series review. Spine 2009; 34: 1480-4; discussion 5.
51. Villavicencio A T, Burneikiene S, Nelson EL, et al. Safety of trans-foraminal lumbar interbody fusion and intervertebral recombi-nant human bone morphogenetic protein-2. J Neurosurg Spine 2005; 3: 436-43.
52. Christensen TJ, Annis P, Hohl JB, et al. Neuroforaminal chondro-cyte metaplasia and clustering associated with recombinant bone morphogenetic protein-2 usage in transforaminal lumbar interbody fusion. Spine J 2014; 14: e23-8.
53. Boden SD, Kang J, Sandhu H, et al. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in clinical studies. Spine 2002; 27: 2662-73.