The efficacy of rhBMP-2 for posterolateral lumbar fusion in smokers

Spine

Volumn 32, Issue 15, 2007, Pages 1693-1698

  Glassman, Steven D ^a,e   Dimar, John R ^a   Burkus, Kenneth ^b   Hardacker, James W ^c   Pryor, Philip W ^c   Boden, Scott D ^d   Carreon, Leah Y ^a  

^a NORTON LEATHERMAN SPINE CENTER   (United States)

^b HUGHSTON CLINIC   (United States)

^c Spine Institute   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NONE   (United States)

Author keywords

Bone graft; Lumbar fusion; rhBMP 2; Smoking

Indexed keywords

AMPLIFY; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BACKACHE; BONE GRAFT; CLINICAL ASSESSMENT; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISABILITY; FEMALE; HUMAN; ILIAC CREST; INTERMETHOD COMPARISON; LEG PAIN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIOGRAPHY; RADIOLOGIST; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; SHORT FORM 36; SMOKING; SPINE FUSION;

BONE AND BONES; BONE MORPHOGENETIC PROTEINS; BONE TRANSPLANTATION; FEMALE; HUMANS; ILIUM; INTERNAL FIXATORS; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; SMOKING; SPINAL FUSION; TOMOGRAPHY, X-RAY COMPUTED; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME; WOUND HEALING;

EID: 34447297304     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e318074c366     Document Type: Article

References (31)

1. Glassman SD, Anagnost SC, Parker A, et al. The effect of cigarette smoking and smoking cessation on spinal fusion. Spine 2000;20:2608-15.
2. Andersen T, Christensen FB, Laursen M, et al. Smoking as a predictor of negative outcome in lumbar spinal fusion. Spine 2001;23:2623-8.
3. Kwon BK, Hilibrand AS, Malloy K, et al. A critical analysis of the literature regarding surgical approach and outcome for adult low-grade isthmic spondylolisthesis. J Spinal Disord Tech 2005;18(suppl):30-40.
4. Brown CW, Orme TJ, Richardson HD. The rate of pseudoarthrosis (surgical nonunion) in patients who are smokers and patients who are nonsmokers: a comparison study. Spine 1986;11:942-3.
5. Whitesides TE, Hanley EN, Fellrath RF. Controversies smoking abstinence: is it necessary before spinal fusion? Spine 1994;17:2012-4.
6. Mirovsky Y, Halperin N, Anekstein Y, et al. Good results of circumferential spine fusion in smokers, using autograft and allograft. Cell Tissue Banking 2002;3:169-73.
7. Burkus JK, Gornet MF, Dickman CA, et al. Anterior lumbar interbody fusion using rhBMP-2 with tapered inter body cages. J Spinal Disord Tech 2002;15:337-47.
8. Burkus JK, Sandhu HS, Gornet MF, et al. Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery. J Bone Joint Surg Am 2005;87:1205-12.
9. Burkus JK, Dorchak JD, Sanders DL. Radiographic assessment of interbody fusion using recombinant human bone morphogenetic protein Type 2. Spine 2003;28:372-7.
10. Abraham EP, Alexander DI, Bailey SI, et al. Evaluation of a new rhBMP-2 formulation in two-level posterolateral lumbar spine fusion. Abstract presented to the American Academy of Orthopaedic Surgeons. 2005:002.
11. Alexander DI, Abraham EP, Bailey SI, et al. A new rhBMP-2 formulation in posterolateral lumbar spine fusion: a prospective, randomized study. Abstract presented to the American Academy of Orthopaedic Surgeons. 2005:003.
12. Patel TC, Erulkar JS, Grauer JN, et al. Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion. Spine 2001;15:1656-61.
13. Silcox DH, Boden SD, Schimandle JH, et al. Reversing the inhibitory effect of nicotine on spinal fusion using an osteoinductive protein extract. Spine 1998;23:291-6.
14. McGeary DD, Mayer TG, Gatchel RJ, et al. Smoking status and psychosocioeconomic outcomes of functional restoration in patients with chronic spinal disability. Spine J 2004;4:170-5.
15. Mooney V, McDermott KL, Song J. Effects of smoking and maturation on long-term maintenance of lumbar spinal fusion success. J Spinal Disord 1999;5:380-5.
16. Lee TC, Ueng SWN, Chen HH, et al. The effect of acute smoking on spinal fusion: an experimental study among rabbits. J Trauma 2005;59:401-7.
17. Daftari TK, Whitesides TE, Heller JG, et al. Nicotine on the revascularization of bone graft. Spine 1994;8:904-11.
18. Wing KJ, Fisher CG, O'Connell JX, et al. Stopping nicotine exposure before surgery. Spine 2000;1:30-4.
19. Theiss SM, Boden SD, Hair G, et al. The effect of nicotine on gene expression during spine fusion. Spine 2000;20:2588-94.
20. Wang H, Yu MJ, Ochani M, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2003;421:384-8.
21. Miao FJ, Green PG, Benowitz N, et al. Central terminals of nociceptors are targets for nicotine suppression of inflammation. Neuroscience 2004;123:777-84.
22. Glassman SD, Rose SM, Dimar JR, et al. The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion. Spine 1998;23:834-8.
23. Reuben SS, Ablett D, Kaye R. High dose nonsteroidal anti-inflammatory drugs compromise spinal fusion. Can J Anesth 2005;52:5:506-12.
24. Park SY, Moon SH, Park MS, et al. The effects of Ketorolac injected via patient controlled analgesic postoperatively on spinal fusion. Yonsei Med J 2005;2:245-51.
25. Battie MC, Videman T, Gill K, et al. Smoking and lumbar intervertebral disc degeneration: an MRI study of identical twins. Spine 1991;16:1015-21.
26. Hadley M, Reddy S. Smoking and the human vertebral column: a review of the impact of cigarette use on vertebral bone metabolism and spinal fusion. Neurosurgery 1997;41:116-24.
27. Cook SD, Patron LP, Christakis PM, et al. Comparison of methods for determining the presence and extent of anterior lumbar interbody fusion. Spine 2004;29:1118-23.
28. Govender PV, Rampersaud YR, Rickards L, et al. Use of Osteogenic protein-1 in spinal fusion: literature review and preliminary results in a prospective series of high-risk cases. Neurosurg Focus 2002;13:e4:1-6.
29. Glassman S, Dimar J, Carreon L, et al. Initial fusion rates with rh-BMP-2 and an HA-TCP/collagen carrier in posterolateral fusion. Spine 2005;30:1694-8.
30. Molinari RW, Bridwell KH, Klepps SJ, et al. Minimum 5-year follow-up of anterior column structural allografts in the thoracic and lumbar spine. Spine 1999;24:967-72.
31. Cizek GR, Boyd LM. Imaging pitfalls of interbody spinal implants. Spine 2000;25:2633-6.