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1
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34948825774
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Role of the t cell in the genesis of angiotensin II induced hypertension and vascular dysfunction
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Guzik TJ, Hoch NE, Brown KA, et al. Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med 2007; 204:2449-2460.
-
(2007)
J Exp Med
, vol.204
, pp. 2449-2460
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Guzik, T.J.1
Hoch, N.E.2
Brown, K.A.3
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2
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84880736883
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Immunosenescent cd8+ t cells and c-x-c chemokine receptor type 3 chemokines are increased in human hypertension
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Youn JC , Yu HT, Lim BJ, et al. Immunosenescent CD8+ T cells and C-X-C chemokine receptor type 3 chemokines are increased in human hypertension. Hypertension 2013; 62:126-133. 3.
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(2013)
Hypertension
, vol.62
, pp. 126-133
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Youn, J.C.1
Yu, H.T.2
Lim, B.J.3
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3
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84919714927
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Oligoclonalcd8+t cells play a critical role in the development of hypertension
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This study demonstrated that CD8+, and not CD4+ T cells, were required for Ang II-induced hypertension. Furthermore, CD8mice were resistant to the antinatiuretic and antidiuretic effects of Ang II
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TrottDW,ThabetSR, Kirabo A, et al. OligoclonalCD8+T cells play a critical role in the development of hypertension. Hypertension 2014; 64:1108-1115. This study demonstrated that CD8+, and not CD4+ T cells, were required for Ang II-induced hypertension. Furthermore, CD8mice were resistant to the antinatiuretic and antidiuretic effects of Ang II. 4.
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(2014)
Hypertension
, vol.64
, pp. 1108-1115
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Trott, D.W.1
Thabet, S.R.2
Kirabo, A.3
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4
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84922394056
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Cd4+ t cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia
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Through adoptive transfer studies, this article highlighted the importance of CD4+ T cells in the development of oxidative stress and high blood pressure during preeclampsia
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Wallace K, Cornelius DC, Scott J, et al. CD4+ T cells are important mediators of oxidative stress that cause hypertension in response to placental ischemia. Hypertension 2014; 64:1151-1158. Through adoptive transfer studies, this article highlighted the importance of CD4+ T cells in the development of oxidative stress and high blood pressure during preeclampsia. 5.
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(2014)
Hypertension
, vol.64
, pp. 1151-1158
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Wallace, K.1
Cornelius, D.C.2
Scott, J.3
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5
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84930893678
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Th17 polarization in pulmonary arterial hypertension
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[Epub ahead of print]. This is the first study to d emonstrate polarization of T cells to the pathogenic Th17 phenotype in patients with pulmonary arterial hypertension
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Hautefort A, Girerd B, Montani D, et al. Th17 polarization in pulmonary arterial hypertension. Chest 2015; 147:1610-1620. doi: 10.1378/chest.14-1678. [Epub ahead of print]. This is the first study to d emonstrate polarization of T cells to the pathogenic Th17 phenotype in patients with pulmonary arterial hypertension.
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(2015)
Chest
, vol.147
, pp. 1610-1620
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Hautefort, A.1
Girerd, B.2
Montani, D.3
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6
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84897086339
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Spironolactone decreases doca-saltinduced organ damage by bl ocking the activation of t helper 17 and the downregulation of regulatory t lymphocytes
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This study showed that the DOCA-salt model of hypertension altered the Th17/Treg ratio, and inhibition of IL-17 reduced arterial hypertension and prevented cardiac remodeling
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Amador CA, Barrientos V, Pena J, et al. Spironolactone decreases DOCA-saltinduced organ damage by bl ocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes. Hypertension 2014; 63:797-803. This study showed that the DOCA-salt model of hypertension altered the Th17/Treg ratio, and inhibition of IL-17 reduced arterial hypertension and prevented cardiac remodeling. 7.
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(2014)
Hypertension
, vol.63
, pp. 797-803
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Amador, C.A.1
Barrientos, V.2
Pena, J.3
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7
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84904472491
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Sex differences in t-lymphocyte tissue infiltration and development of angiotensin II hypertension
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This article highlights that the sex differences observed in hypertension may be because of difference in T cell function, since transfer of male, but not female, T cells recapitulated Ang II-induced hypertensi on in Rag1mice
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Pollow DP, Uhrlaub J, Romero-Aleshire MJ, et al. Sex differences in T-lymphocyte tissue infiltration and development of angiotensin II hypertension. Hyp ertension 2014; 64:384-390. This article highlights that the sex differences observed in hypertension may be because of difference in T cell function, since transfer of male, but not female, T cells recapitulated Ang II-induced hypertensi on in Rag1mice.
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(2014)
Hypertension
, vol.64
, pp. 384-390
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Pollow, D.P.1
Uhrlaub, J.2
Romero-Aleshire, M.J.3
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8
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33745712914
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The sympathetic control of blood pressure
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Guyenet PG. The sympathetic control of blood pressure. Nat Rev Neurosci 2006; 7:335-346.
-
(2006)
Nat Rev Neurosci
, vol.7
, pp. 335-346
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Guyenet, P.G.1
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9
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84930847152
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Roles for the sympathetic nervous system, renal nerves, and cns melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats
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Maranon RO, Lima R, Spradley FT, et al. Roles for the sympathetic nervous system, renal nerves, and CNS melanocortin-4 receptor in the elevated blood pressure in hyperandrogenemic female rats. Am J Physiol Regul Int egr Comp Physiol 2014; 308:R708-R713.
-
(2014)
Am J Physiol Regul Integr Comp Physiol
, vol.308
, pp. R708-R713
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Maranon, R.O.1
Lima, R.2
Spradley, F.T.3
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10
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77955171998
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Central and peripheral mechanisms of tlymphocyte activation and vascular inflammation produced by angiotensin iiinduce d hypertension
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Marvar PJ, Thabet SR, Guzik TJ, et al. Central and peripheral mechanisms of Tlymphocyte activation and vascular inflammation produced by angiotensin IIinduce d hypertension. Circ Res 2010; 107:263-270.
-
(2010)
Circ Res
, vol.107
, pp. 263-270
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Marvar, P.J.1
Thabet, S.R.2
Guzik, T.J.3
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11
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83655167069
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Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic k idney disease
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Fujita M, Ando K, Kawarazaki H, et al. Sympathoexcitation by brain oxidative stress mediates arterial pressure elevation in salt-induced chronic k idney disease. Hypertension 2012; 59:105-112.
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(2012)
Hypertension
, vol.59
, pp. 105-112
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Fujita, M.1
Ando, K.2
Kawarazaki, H.3
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12
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84863116727
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How nacl raises blood pressure: A new paradigm for the pathogenesis of salt-dependent hypertension
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Blaustein MP, Leenen FH, Chen L, et al. How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol 2012; 302:H1031-H1049.
-
(2012)
Am J Physiol Heart Circ Physiol
, vol.302
, pp. H1031-H1049
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Blaustein, M.P.1
Leenen, F.H.2
Chen, L.3
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13
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84912085339
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The angiogenic factor plgf mediates a neuroimmune interaction in the spleen to allow the onset of hypertension
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This study revealed that the ' angiogenic cytokine' placental growth factor served as a link connecting the sympathetic nervous system and the splenic immune system
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Carnevale D, Pallante F, Fardella V, et al. The angiogenic factor PlGF mediates a neuroimmune interaction in the spleen to allow the onset of hypertension. Immunity 2014; 41:737-752. This study revealed that the ' angiogenic cytokine' placental growth factor served as a link connecting the sympathetic nervous system and the splenic immune system.
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(2014)
Immunity
, vol.41
, pp. 737-752
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Carnevale, D.1
Pallante, F.2
Fardella, V.3
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14
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78650711240
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Inhibition and genetic ablation of the b7/cd28 t-cell costimulation axis prevents experimental hypertension
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Vinh A, Chen W, Bli nder Y, et al. Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation 2010; 122:2529-2537.
-
(2010)
Circulation
, vol.122
, pp. 2529-2537
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Vinh, A.1
Chen, W.2
Bli nder, Y.3
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15
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84894492650
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Cd247 modulates blood pressure by altering t-lymphocyte infiltration in the kidney
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Through zinc finger nuclease technology, this is the first study to demonstrate genetic manipulation of the T cell receptor in rats, resulting in blunted amplification of salt-induced hypertension and renal damage
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Rudemiller N, Lund H, Jacob HJ, et al. CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney. Hypertension 2014; 63:559-564. Through zinc finger nuclease technology, this is the first study to demonstrate genetic manipulation of the T cell receptor in rats, resulting in blunted amplification of salt-induced hypertension and renal damage.
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(2014)
Hypertension
, vol.63
, pp. 559-564
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Rudemiller, N.1
Lund, H.2
Jacob, H.J.3
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16
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29444437733
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Beta 1)-Adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy
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Jahns R,Boivin V Lohse MJ. beta 1)-Adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy. Trends Cardiovasc Med 2006 16 20-24.
-
(2006)
Trends Cardiovasc Med
, vol.16
, pp. 20-24
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Jahns, R.1
Boivin, V.2
Lohse, M.J.3
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17
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0031037595
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Alpha 1-Adrenergic receptor antibodies in patients with primary hypertension
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Luther HP, Homuth V, Wallukat G. Alpha 1-Adrenergic receptor antibodies in patients with primary hypertension. Hypertension 1997; 29: 678-682.
-
(1997)
Hypertension
, vol.29
, pp. 678-682
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Luther, H.P.1
Homuth, V.2
Wallukat, G.3
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18
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84880310628
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Angiotensin receptor agonistic autoantibodies and hypertension: Preeclampsia and beyond
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Xia Y, Kellems RE. Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond. Circ Res 2013; 113:78-87.
-
(2013)
Circ Res
, vol.113
, pp. 78-87
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Xia, Y.1
Kellems, R.E.2
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19
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84914664859
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Preventing autoimmunity protects against the development of hypertension and renal injury
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This study observed decreased cytokine production and attenuation of systemic lupus erythem atosus-induced hypertension by preventing autoimmunity through B cell depletion
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Mathis KW, Wallace K, Flynn ER, et al. Preventing autoimmunity protects against the development of hypertension and renal injury. Hypertension 2014; 64:792-800. This study observed decreased cytokine production and attenuation of systemic lupus erythem atosus-induced hypertension by preventing autoimmunity through B cell depletion.
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(2014)
Hypertension
, vol.64
, pp. 792-800
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Mathis, K.W.1
Wallace, K.2
Flynn, E.R.3
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20
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84861154898
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Activating autoantibodies to the angiotensin II type i receptor play an important role in med iating hypertension in response to adoptive transfer of cd4+ t lymphocytes from placental ischemic rats
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Novotny SR, Wallace K, Heath J, et al. Activating autoantibodies to the angiotensin II type I receptor play an important role in med iating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic rats. Am J Physiol Regulatory Integrative Comparative Physiol 2012; 302:R1197-R1201.
-
(2012)
Am J Physiol Regulatory Integrative Comparative Physiol
, vol.302
, pp. R1197-R1201
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Novotny, S.R.1
Wallace, K.2
Heath, J.3
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21
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79551490166
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Inflammation, immunity, and hypertension
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Harrison DG, Guzik TJ, Lob HE, et al. Inflammation, immunity, and hypertension. Hypertension 2011; 57:132-140.
-
(2011)
Hypertension
, vol.57
, pp. 132-140
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Harrison, D.G.1
Guzik, T.J.2
Lob, H.E.3
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22
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84873280995
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Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension
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Pons H, Ferrebuz A,Quiroz Y, et al. Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension. Am J Physiol Renal Physiol 2013; 304:F289-F299.
-
(2013)
Am J Physiol Renal Physiol
, vol.304
, pp. F289-F299
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Pons, H.1
Ferrebuz Aquiroz, Y.2
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23
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84907494957
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Dc isoketal-modified proteins activate t cells and promote hypertension
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This article suggests that isoketals modified in dendritic cells v ia reactive oxygen species production are no longer recognized as self, and thereby act as a neoantigen inducing cytokine production and activation of T cells
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Kirabo A, Fontana V, de Faria AP, et al. DC isoketal-modified proteins activate T cells and promote hypertension. J Clin Investig 2014; 124: 4642-4656. This article suggests that isoketals modified in dendritic cells v ia reactive oxygen species production are no longer recognized as self, and thereby act as a neoantigen inducing cytokine production and activation of T cells.
-
(2014)
J Clin Investig
, vol.124
, pp. 4642-4656
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Kirabo, A.1
Fontana, V.2
De Faria, A.P.3
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24
-
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0042417593
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Autoimmune factors associated with infarction of the kidney
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White FN, Grollman A. Autoimmune factors associated with infarction of the kidney. Nephron 1964; 1:93-102.
-
(1964)
Nephron
, vol.1
, pp. 93-102
-
-
White, F.N.1
Grollman, A.2
-
25
-
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0017194521
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Evidence for an initial, thymus independent and a chronic, thymus dependent phase of doca and salt hypertension in mice
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Svendsen UG. Evidence for an initial, thymus independent and a chronic, thymus dependent phase of DOCA and salt hypertension in mice. Acta Pathol Microbiol Scand A 1976; 84:523-528.
-
(1976)
Acta Pathol Microbiol Scand A
, vol.84
, pp. 523-528
-
-
Svendsen, U.G.1
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26
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84876787121
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Sodium chloride drives autoimmune disease by the induction of pathogenic th17 cells
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Kleinewietfeld M, Manzel A, Titze J, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013; 496:518-522.
-
(2013)
Nature
, vol.496
, pp. 518-522
-
-
Kleinewietfeld, M.1
Manzel, A.2
Titze, J.3
-
27
-
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84876798411
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Induction of pathogenic th17 cells by inducible salt-sensing kinase sgk1
-
Wu C, Yosef N, Thalhamer T, et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 2013; 496:513-517. 28.
-
(2013)
Nature
, vol.496
, pp. 513-517
-
-
Wu, C.1
Yosef, N.2
Thalhamer, T.3
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28
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84925497671
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Sodium chloride, sgk1, and th17 activation
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In-depth review discussing elevated salt, serum-And glucocorticoid-inducible kinase-1 (SGK-1), and the differentiation and aberrant activation of Th17 cells
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Binger KJ, Linker RA, Muller DN, Kleinewietfeld M. Sodium chloride, SGK1, and Th17 activation. Pflugers Arch Eur J Physiol 2015; 467:543-550. In-depth review discussing elevated salt, serum-And glucocorticoid-inducible kinase-1 (SGK-1), and the differentiation and aberrant activation of Th17 cells.
-
(2015)
Pflugers Arch Eur J Physiol
, vol.467
, pp. 543-550
-
-
Binger, K.J.1
Linker, R.A.2
Muller, D.N.3
Kleinewietfeld, M.4
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29
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84930871994
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Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: A longitudinal study
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This recent human longitudinal study examined the effects of long-term salt-intake reduction and changes in the immune system. A reduction in total monocyte number as well as cytokine production was observed in patients maintained on a lower-s alt diet
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Yi B, Titze J, Rykova M, et al. Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: a longitudinal study. Trans l Res 2014. This recent human longitudinal study examined the effects of long-term salt-intake reduction and changes in the immune system. A reduction in total monocyte number as well as cytokine production was observed in patients maintained on a lower-s alt diet.
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(2014)
Transl Res
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Yi, B.1
Titze, J.2
Rykova, M.3
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30
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15744400464
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Dietary protein source determines the degree of hypertension and renal disease in the dahl salt-sensitive rat
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Mattson DL, Meister CJ, Marcelle ML. Dietary protein source determines the degree of hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension 2005; 45:736-741.
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(2005)
Hypertension
, vol.45
, pp. 736-741
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Mattson, D.L.1
Meister, C.J.2
Marcelle, M.L.3
-
31
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79551491896
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High dietary protein exacerbates hypertension and renal damage in dahl ss rats by increasing infiltrating immune cells in the kidney
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De Miguel C, Lund H, Mattson DL. High dietary protein exacerbates hypertension and renal damage in Dahl SS rats by increasing infiltrating immune cells in the kidney. Hypertension 2011; 57:269-274.
-
(2011)
Hypertension
, vol.57
, pp. 269-274
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De Miguel, C.1
Lund, H.2
Mattson, D.L.3
-
32
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84921562280
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Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in dahl salt-sensitive rats
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Geurts AM, Mattson DL, Liu P, et al. Maternal diet during gestation and lactation modifies the severity of salt-induced hypertension and renal injury in Dahl salt-sensitive rats. Hypertension 2015; 65:447-455.
-
(2015)
Hypertension
, vol.65
, pp. 447-455
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Geurts, A.M.1
Mattson, D.L.2
Liu, P.3
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