QT interval correction assessment in the anesthetized guinea pig

Journal of Pharmacological and Toxicological Methods

Volumn 75, Issue , 2015, Pages 52-61

  Morissette, Pierre ^a   Regan, Hillary K ^a   Fitzgerald, Kevin ^a   Bernasconi, Sylvain ^a,b   Gerenser, Pamela ^a   Travis, Jeffrey ^a   Fanelli, Patrick ^a   Sannajust, Frederick ^a   Regan, Christopher P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE   (France)

Author keywords

Anesthetized guinea pig; Heart rate QT correction; ICH S7A; ICH S7B; Paced guinea pig; Safety pharmacology

Indexed keywords

DOFETILIDE; EPHEDRINE; IVABRADINE; KETAMINE; SOTALOL; XYLAZINE; BENZAZEPINE DERIVATIVE; PHENETHYLAMINE DERIVATIVE; SULFONAMIDE;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG INFUSION; GUINEA PIG; HEART ATRIUM PACING; HEART PACING; HEART RATE; HEART REPOLARIZATION; MALE; NONHUMAN; QTC INTERVAL; SENSITIVITY ANALYSIS; ANIMAL; ANIMAL MODEL; DRUG EFFECTS; ELECTROCARDIOGRAPHY; LONG QT SYNDROME; PHYSIOLOGY; PROCEDURES;

ANIMALS; BENZAZEPINES; ELECTROCARDIOGRAPHY; EPHEDRINE; GUINEA PIGS; HEART RATE; KETAMINE; LONG QT SYNDROME; MALE; MODELS, ANIMAL; PHENETHYLAMINES; SOTALOL; SULFONAMIDES; XYLAZINE;

EID: 84942549779     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2015.05.007     Document Type: Article

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