IL-17A and the promotion of neutrophilia in acute exacerbation of chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine

Volumn 192, Issue 4, 2015, Pages 428-437

  Roos, Abraham B ^a,b   Sethi, Sanjay ^c   Nikota, Jake ^d   Wrona, Catherine T ^c   Dorrington, Michael G ^d   Sandén, Caroline ^a   Bauer, Carla M T ^e   Shen, Pamela ^c   Bowdish, Dawn ^b   Stevenson, Christopher S ^e   Erjefält, Jonas S ^a   Stampfli, Martin R ^b,d  

^a LUND UNIVERSITY   (Sweden)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY AT BUFFALO   (United States)

^d MCMASTER UNIVERSITY   (Canada)

^e HOFFMANN LA ROCHE INC   (United States)

Author keywords

COPD; Disease exacerbation; Haemophilus influenzae; IL 17A; Neutrophil

Indexed keywords

CHEMOATTRACTANT; CIGARETTE SMOKE; CXCL1 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; INTERLEUKIN 17; INTERLEUKIN 8;

ADAPTIVE IMMUNITY; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL LOAD; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INFLUENZA; LUNG CLEARANCE; LUNG LAVAGE; LYMPHOID CELL; MALE; MOUSE; NATURAL KILLER CELL; NEUTROPHIL; NEUTROPHILIA; NONHUMAN; NONTYPEABLE HAEMOPHILUS INFLUENZAE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOKING; SPUTUM ANALYSIS; TH17 CELL; WILD TYPE; ADVERSE EFFECTS; ANIMAL; BAGG ALBINO MOUSE; COMPLICATION; DISEASE MODEL; HAEMOPHILUS INFECTION; HAEMOPHILUS INFLUENZAE; LEUKOCYTE COUNT; METABOLISM; MIDDLE AGED; NEUTROPHIL CHEMOTAXIS; PHYSIOLOGY;

AGED; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HAEMOPHILUS INFECTIONS; HAEMOPHILUS INFLUENZAE; HUMANS; INTERLEUKIN-17; LEUKOCYTE COUNT; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; NEUTROPHIL INFILTRATION; NEUTROPHILS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING;

EID: 84942525059     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201409-1689OC     Document Type: Article

References (37)

1. Vestbo J, Decramer M. Global strategy for diagnosis, management, and prevention of COPD. 2014 Jan [accessed 2014 Jul 14]. Available from: http://www.goldcopd.org/guidelines-global-strategy-for-diagnosis-management.html
2. Kanner RE, Anthonisen NR, Connett JE; Lung Health Study Research Group. Lower respiratory illnesses promote FEV(1) decline in current smokers but not ex-smokers with mild chronic obstructive pulmonary disease: results from the lung health study. Am J Respir Crit Care Med 2001;164:358-364.
3. Donaldson GC, Seemungal TAR, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002;57:847-852.
4. Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, et al. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 2010;120:1762-1773.
5. Sieve AN, Meeks KD, Bodhankar S, Lee S, Kolls JK, Simecka JW, Berg RE. A novel IL-17-dependent mechanism of cross protection: respiratory infection with mycoplasma protects against a secondary listeria infection. Eur J Immunol 2009;39:426-438.
6. Happel KI, Zheng M, Young E, Quinton LJ, Lockhart E, Ramsay AJ, Shellito JE, Schurr JR, Bagby GJ, Nelson S, et al. Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J Immunol 2003;170:4432-4436.
7. Tan HL, Rosenthal M. IL-17 in lung disease: friend or foe? Thorax 2013;68:788-790.
8. Ivanov S, Lindén A. Interleukin-17 as a drug target in human disease. Trends Pharmacol Sci 2009;30:95-103.
9. Hoshino H, Laan M, Sjöstrand M, Lötvall J, Skoogh B-E, Lindén A. Increased elastase and myeloperoxidase activity associated with neutrophil recruitment by IL-17 in airways in vivo. J Allergy Clin Immunol 2000;105:143-149.
10. Chen K, Pociask DA, McAleer JP, Chan YR, Alcorn JF, Kreindler JL, Keyser MR, Shapiro SD, Houghton AM, Kolls JK, et al. IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke. PLoS ONE 2011;6:e20333.
11. Chang Y, Nadigel J, Boulais N, Bourbeau J, Maltais F, Eidelman DH, Hamid Q. CD8 positive T cells express IL-17 in patients with chronic obstructive pulmonary disease. Respir Res 2011;12:43.
12. Eustace A, Smyth LJ, Mitchell L, Williamson K, Plumb J, Singh D. Identification of cells expressing IL-17A and IL-17F in the lungs of patients with COPD. Chest 2011;139:1089-1100.
13. + cells in the lung tissue of patients with stable chronic obstructive pulmonary disease (COPD) and smokers. Int Immunopharmacol 2013;15:58-66.
14. Di Stefano A, Caramori G, Gnemmi I, Contoli M, Vicari C, Capelli A, Magno F, D'Anna SE, Zanini A, Brun P, et al. T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients. Clin Exp Immunol 2009;157:316-324.
15. Roos AB, Sandén C, Mori M, Bjermer L, Stampfli MR,Erjefält JS. IL-17A is elevated in end-stage COPD and contributes to cigarette smoke-induced lymphoid neogenesis. Am J Respir Crit Care Med 2015;191:1232-1241.
16. Sethi S, Murphy TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med 2008;359:2355-2365.
17. Garmendia J, Martí-Lliteras P, Moleres J, Puig C, Bengoechea JA. Genotypic and phenotypic diversity of the noncapsulated Haemophilus influenzae: adaptation and pathogenesis in the human airways. Int Microbiol 2012;15:159-172.
18. Wilkinson TMA, Hurst JR, Perera WR, Wilks M, Donaldson GC, Wedzicha JA. Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD. Chest 2006;129:317-324.
19. Gaschler GJ, Skrtic M, Zavitz CC, Lindahl M, Onnervik PO, Murphy TF, Sethi S, Stämpfli MR. Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile. Am J Respir Crit Care Med 2009;179:666-675.
20. Gaschler GJ, Zavitz CC, Bauer CM, Stämpfli MR. Mechanisms of clearance of nontypeable Haemophilus influenzae from cigarette smoke-exposed mouse lungs. Eur Respir J 2010;36:1131-1142.
21. Roos AB, Nikota JK, Dorrington MG, Bauer CMT, Bowdish D, Stevenson CS, Erjefalt JS, Stamplfi MR. IL-17A is critical for non-typeable Haemophilus influenzae exacerbation of cigarette smoke-induced inflammation [abstract]. Am J Respir Crit Care Med 2014;189:A2710.
22. Sethi S, Evans N, Grant BJ, Murphy TF. New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med 2002;347:465-471.
23. Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, Zhang P, Favara M, Malcolm KC, Guttentag S, et al. IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro. J Immunol 2011;186:3197-3205.
24. Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, et al. T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. J Immunol 2013;191:3100-3111.
25. McAllister F, Henry A, Kreindler JL, Dubin PJ, Ulrich L, Steele C, Finder JD, Pilewski JM, Carreno BM, Goldman SJ, et al. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol 2005;175:404-412.
26. Oosting M, van de Veerdonk FL, Kanneganti TD, Sturm P, Verschueren I, Berende A, van der Meer JW, Kullberg BJ, Netea MG, Joosten LA. Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism. Eur J Immunol 2011;41:172-181.
27. Botelho FM, Bauer CM, Finch D, Nikota JK, Zavitz CC, Kelly A, Lambert KN, Piper S, Foster ML, Goldring JJ, et al. IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice. PLoS ONE 2011;6:e28457.
28. +) lymphoid cells. Nature 2010;463:540-544.
29. Stämpfli MR, Anderson GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol 2009;9:377-384.
30. Zrioual S, Ecochard R, Tournadre A, Lenief V, Cazalis M-A, Miossec P. Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes. J Immunol 2009;182:3112-3120.
31. Sethi S, Mahler DA, Marcus P, Owen CA, Yawn B, Rennard S. Inflammation in COPD: implications for management. Am J Med 2012;125:1162-1170.
32. Lugade AA, Bogner PN, Thatcher TH, Sime PJ, Phipps RP, Thanavala Y. Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection. J Immunol 2014;192:5226-5235.
33. Overbeek JA, Penning-van Beest FJ, Balp MM, Dekhuijzen PN, Herings RM. Burden of exacerbations in patients with moderate to very severe COPD in the Netherlands: a real-life study. COPD 2015;12:132-143.
34. King PT, Lim S, Pick A, Ngui J, Prodanovic Z, Downey W, Choong C, Kelman A, Baranyai E, Francis M, et al. Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol 2013;131:1314-1321, e1314.
35. Moghaddam SJ, Ochoa CE, Sethi S, Dickey BF. Nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease and lung cancer. Int J Chron Obstruct Pulmon Dis 2011;6:113-123.
36. Nikota JK, Stämpfli MR. Cigarette smoke-induced inflammation and respiratory host defense: Insights from animal models. Pulm Pharmacol Ther 2012;25:257-262.
37. Ye P, Garvey PB, Zhang P, Nelson S, Bagby G, Summer WR, Schwarzenberger P, Shellito JE, Kolls JK. Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol 2001;25:335-340.