Palladium-Catalyzed One-Pot Reaction of Hydrazones, Dihaloarenes, and Organoboron Reagents: Synthesis and Cytotoxic Activity of 1,1-Diarylethylene Derivatives

Journal of Organic Chemistry

Volumn 80, Issue 13, 2015, Pages 6715-6727

  Roche, Maxime ^a   Salim, Salim Mmadi ^a   Bignon, Jérôme ^b   Levaique, Hélène ^b   Brion, Jean Daniel ^a   Alami, Mouad ^a   Hamze, Abdallah ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELL CULTURE; CYTOTOXICITY; FINANCIAL MARKETS; STYRENE; SYNTHESIS (CHEMICAL);

ANTI-PROLIFERATIVE ACTIVITIES; CANCER CELL LINES; CROSS COUPLING REACTIONS; CYTOTOXIC ACTIVITIES; N-TOSYLHYDRAZONES; NANOMOLAR CONCENTRATION; ONE-POT REACTION; PALLADIUM-CATALYZED;

CHEMICAL REACTIONS;

1 (3 METHOXYPROP 1 EN 1 YL) 4 [1 (P TOLYL)VINYL]BENZENE; 2 METHOXY 5 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL] 1,1 BIPHENYL; 2 PHENYL 5 [1 (P TOLYL)VINYL]PYRIDINE; 2 [1 (3',4',5' TRIMETHOXY [1,1 BIPHENYL] 3 YL)VINYL]NAPHTHALENE; 2 [1 (3,4 DIMETHOXYPHENYL)VINYL] 1,1 BIPHENYL; 2 [4 [1 (P TOLYL)VINYL]PHENYL]NAPHTHALENE; 3 [1 (4 ISOBUTYLPHENYL)VINYL] 1,1 BIPHENYL; 3 [1 (4 METHOXYPHENYL)VINYL] 1,1 BIPHENYL; 4 (3,3 DIMETHYLBUT 1 EN 2 YL) 4' METHOXY 1,1 BIPHENYL; 4 [1 (3 FLUORO 4 METHOXYPHENYL)VINYL] 1,1 BIPHENYL; 4 [1 (4 FLUOROPHENYL)VINYL] 4' METHOXY 1,1 BIPHENYL; 4 [1 (4 METHOXYPHENYL)VINYL] 1,1 BIPHENYL; 4 [1 (P TOLYL)VINYL] 1,1 BIPHENYL; 4 [1 [(1,1 BIPHENYL) 4 YL]VINYL]BENZONITRILE; 4 [2 METHOXY 5 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]PHENYL]PYRIDINE; 5 (4 METHOXYPHENYL) 1 METHYL 3 [1 (P TOLYL)VINYL] 1H INDOLE; 5 [1 [3 (2 CYCLOPROPYLVINYL) 4 METHOXYPHENYL]VINYL] 1,2,3 TRIMETHOXYBENZENE; 5 [2 METHOXY 5 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]PHENYL] 1 METHYL 1H PYRAZOLE; 5 [4 [1 (4 FLUOROPHENYL)VINYL]PHENYL] 1 METHYL 1H PYRAZOLE; 5 [4 [1 (4 ISOBUTYLPHENYL)VINYL]PHENYL]1 METHYL 1H INDOLE; 6 (4 METHOXYPHENYL) 1 METHYL 3 [1 (P TOLYL)VINYL]QUINOLIN 2(1H) ONE; ANTINEOPLASTIC AGENT; ETHYLENE DERIVATIVE; HYDRAZONE DERIVATIVE; ISOPROPYL 4' [1 (P TOLYL)VINYL] [1,1 BIPHENYL] 4 CARBOXYLATE; ORGANOBORON DERIVATIVE; PALLADIUM; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [1 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL)VINYL] [1,1 BIPHENYL]1 (4 YL)ETHANONE; 5-(1-(3-(2-CYCLOPROPYLVINYL)-4-METHOXYPHENYL)VINYL)-1,2,3-TRIMETHOXYBENZENE; BORON DERIVATIVE; CYCLOPROPANE DERIVATIVE; VINYL DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CHEMICAL BOND; CROSS COUPLING REACTION; CYTOTOXICITY; ONE POT SYNTHESIS; CATALYSIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HCT116 CELL LINE; HUMAN; SYNTHESIS;

BORON COMPOUNDS; CATALYSIS; CELL LINE; CYCLOPROPANES; ETHYLENES; HCT116 CELLS; HUMANS; HYDRAZONES; MOLECULAR STRUCTURE; PALLADIUM; VINYL COMPOUNDS;

EID: 84942434931     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/acs.joc.5b00880     Document Type: Article

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