Genetic analysis reveals a longevity-associated protein modulating endothelial function and angiogenesis

Circulation Research

Volumn 117, Issue 4, 2015, Pages 333-345

  Villa, Francesco ^a   Carrizzo, Albino ^b   Spinelli, Chiara C ^a   Ferrario, Anna ^a   Malovini, Alberto ^c   Maciąg, Anna ^d   Damato, Antonio ^b   Auricchio, Alberto ^e,f   Spinetti, Gaia ^d   Sangalli, Elena ^d   Dang, Zexu ^g   Madonna, Michele ^b   Ambrosio, Mariateresa ^b   Sitia, Leopoldo ^h   Bigini, Paolo ^h   Calì, Gaetano ⁱ   Schreiber, Stefan ^j   Perls, Thomas ^k   Fucile, Sergio ^b,l   Mulas, Francesca ^c   Nebel, Almut ^j   Bellazzi, Riccardo ^c   Madeddu, Paolo ^g   Vecchione, Carmine ^b,m   Puca, Annibale A ^d,m   more..

^a INSTITUTE OF BIOMEDICAL TECHNOLOGIES   (Italy)

^b IRCCS NEUROMED   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d IRCCS MULTIMEDICA   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^g UNIVERSITY OF BRISTOL   (United Kingdom)

^h MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

ⁱ CNR   (Italy)

^j UNIVERSITY OF KIEL   (Germany)

^k BOSTON MEDICAL CENTER   (United States)

^l SAPIENZA UNIVERSITY OF ROME   (Italy)

^m UNIVERSITY OF SALERNO   (Italy)

more..

Author keywords

Aging; Endothelial function; Endothelial nitric oxide synthase; Endothelial progenitor cell; Longevity; Vascular reactivity

Indexed keywords

ANTIHYPERTENSIVE AGENT; BACTERICIDAL PERMEABILITY INCREASING FOLD CONTAINING FAMILY B MEMBER 4 PROTEIN; BACTERICIDAL PERMEABILITY INCREASING PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; PROTEIN 14 3 3; PROTEIN KINASE R; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; BPIFB4 PROTEIN, HUMAN; NOS3 PROTEIN, HUMAN; NOS3 PROTEIN, RAT; PERK KINASE; PHOSPHOPROTEIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; BLOOD VESSEL WALL; CARDIOVASCULAR GENE THERAPY; CONTROLLED STUDY; EMBRYO; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HYPERTENSION; IN VIVO GENE TRANSFER; MECHANICAL STRESS; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PERIPHERAL EDEMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS REGULATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR SURGERY; VASODILATATION; AGE; AGED; ANIMAL; C57BL MOUSE; CELL MOTION; CLINICAL TRIAL; DISEASE MODEL; EUROPE; FEMALE; GENE THERAPY; GENETIC ASSOCIATION; GENETIC TRANSFECTION; GENETICS; GENOTYPE; HEK293 CELL LINE; HINDLIMB; ISCHEMIA; LONGEVITY; MALE; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; PHENOTYPE; PHOSPHORYLATION; RNA INTERFERENCE; SKELETAL MUSCLE; SPONTANEOUSLY HYPERTENSIVE RAT; UMBILICAL VEIN ENDOTHELIAL CELL; UNITED STATES; VASCULARIZATION; VERY ELDERLY;

14-3-3 PROTEINS; AGE FACTORS; AGED; AGED, 80 AND OVER; ANIMALS; BLOOD PRESSURE; CELL MOVEMENT; DISEASE MODELS, ANIMAL; EIF-2 KINASE; ENDOTHELIAL PROGENITOR CELLS; EUROPE; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC THERAPY; GENOTYPE; HEK293 CELLS; HINDLIMB; HSP90 HEAT-SHOCK PROTEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPERTENSION; ISCHEMIA; LONGEVITY; MALE; MICE, INBRED C57BL; MIDDLE AGED; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE TYPE III; PHENOTYPE; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS, INBRED SHR; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TRANSFECTION; UNITED STATES; VASODILATION;

EID: 84942423509     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.117.305875     Document Type: Article

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