Role of kinin b2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential

Circulation Research

Volumn 103, Issue 11, 2008, Pages 1335-1343

  Kränkel, Nicolle ^a   Katare, Rajesh G ^a   Siragusa, Mauro ^a   Barcelos, Luciola S ^a   Campagnolo, Paola ^a   Mangialardi, Giuseppe ^a   Fortunato, Orazio ^c   Spinetti, Gaia ^c   Tran, Nguyen ^b   Zacharowski, Kai ^b   Wojakowski, Wojciech ^d   Mroz, Iwona ^d   Herman, Andrew ^a   Manning Fox, Jocelyn E ^e   MacDonald, Patrick E ^e   Schanstra, Joost P ^f,g   Bascands, Jean Loup ^f,g   Ascione, Raimondo ^a   Angelini, Gianni ^a   Emanueli, Costanza ^a   Madeddu, Paolo ^a   more..

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b Cellular and Molecular Medicine   (United Kingdom)

^c IRCCS MULTIMEDICA   (Italy)

^d MEDICAL UNIVERSITY OF SILESIA   (Poland)

^e UNIVERSITY OF ALBERTA   (Canada)

^f INSERM   (France)

^g UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Angiogenesis; Bradykinin; Migration; Progenitor recruitment; Therapeutic neovascularization

Indexed keywords

BRADYKININ; CD133 ANTIGEN; CD34 ANTIGEN; ICATIBANT; KININ BETA 2 RECEPTOR; KININ DERIVATIVE; MATRIGEL; UNCLASSIFIED DRUG; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRADYKININ B2 RECEPTOR; DRUG DERIVATIVE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BLOOD CELL; BONE MARROW CELL; CELL CULTURE; CELL HOMING; CELL MIGRATION; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENDOTHELIUM CELL; HEART INFARCTION; HUMAN; HUMAN CELL; LIMB ISCHEMIA; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STABLE ANGINA PECTORIS; STEM CELL; ANGINA PECTORIS; ANIMAL; BIOLOGICAL THERAPY; CELL MOTION; CYTOLOGY; DRUG EFFECT; FLOW CYTOMETRY; GENETICS; HEART MUSCLE ISCHEMIA; HEART MUSCLE REVASCULARIZATION; METHODOLOGY; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; STEM CELL TRANSPLANTATION; TRANSPLANTATION;

ADRENERGIC BETA-AGONISTS; ANGINA PECTORIS; ANIMALS; BRADYKININ; CELL MOVEMENT; FLOW CYTOMETRY; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REVASCULARIZATION; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTOR, BRADYKININ B2; STEM CELL TRANSPLANTATION; STEM CELLS; TISSUE THERAPY;

EID: 58149330265     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.179952     Document Type: Article

References (40)

1. Kawamoto A, Losordo DW. Endothelial progenitor cells for cardiovascular regeneration. Trends Cardiovasc Med. 2008;18:33-37.
2. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S. Number and migratory activity of circulating endothe-lial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res. 2001;89:e1-e7.
3. Segal MS, Shah R, Afzal A, Perrault CM, Chang K, Schuler A, Beem E, Shaw LC, Calzi SL, Harrison JK, Tran-Son-Tay R, Grant MB. Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes. Diabetes. 2006;55: 102-109.
4. Chavakis E, Urbich C, Dimmeler S. Homing and engraftment of progenitor cells: a prerequisite for cell therapy. J Mol Cell Cardiol. 2008 Jan 18 [Epub ahead of print].
5. Choi J, Hur J, Yoon C, Kim J, Lee C, Youn S, Oh I, Skurk C, Murohara T, Park Y, Walsh K, Kim H. Augmentation of therapeutic angiogenesis using genetically modified human endothelial progenitor cells with altered glycogen synthase kinase-3beta activity. J Biol Chem. 2004;279: 49430-49438.
6. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999;399: 597-601.
7. Fisslthaler B, Dimmeler S, Hermann C, Busse R, Fleming I. Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress. Acta Physiol Scand. 2000;168:81-88.
8. Zeng G, Nystrom FH, Ravichandran LV, Cong LN, Kirby M, Mostowski H, Quon MJ. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 2000;101:1539-1545.
9. Madeddu P, Emanueli C, El-Dahr S. Mechanisms of disease: the tissue kallikrein-kinin system in hypertension and vascular remodeling. Nat Clin Pract Nephrol. 2007;3:208-221.
10. Linz W, Wiemer G, Gohlke P, Unger T, Scholkens BA. Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors. Pharmacol Rev. 1995;47:25-49.
11. Duncan AM, Burrell LM, Kladis A, Campbell DJ. Angiotensin and bradykinin peptides in rats with myocardial infarction. J Card Fail. 1997;3:41-52.
12. Emanueli C, Zacheo A, Minasi A, Chao J, Chao L, Salis MB, Stacca T, Straino S, Capogrossi MC, Madeddu P. Adenovirus-mediated human tissue kallikrein gene delivery induces angiogenesis in normoperfused skeletal muscle. Arterioscler Thromb Vasc Biol. 2000;20:2379-2385. (Pubitemid 30825071)
13. Morbidelli L, Parenti A, Giovannelli L, Granger HJ, Ledda F, Ziche M. B1 receptor involvement in the effect of bradykinin on venular endothelial cell proliferation and potentiation of FGF-2 effects. Br J Pharmacol. 1998;124:1286-1292. (Pubitemid 28333954)
14. Emanueli C, Salis MB, Stacca T, Pintus G, Kirchmair R, Isner JM, Pinna A, Gaspa L, Regoli D, Cayla C, Pesquero JB, Bader M, Madeddu P. Targeting kinin B(1) receptor for therapeutic neovascularization. Circulation. 2002;105:360-366.
15. Silvestre JS, Bergaya S, Tamarat R, Duriez M, Boulanger CM, Levy BI. Proangiogenic effect of angiotensin-converting enzyme inhibition is mediated by the bradykinin B(2) receptor pathway. Circ Res. 2001;89: 678-683.
16. Parenti A, Morbidelli L, Ledda F, Granger HJ, Ziche M. The bradyki-nin/B1 receptor promotes angiogenesis by up-regulation of endogenous FGF-2 in endothelium via the nitric oxide synthase pathway. FASEB J. 2001;15:1487-1489.
17. Emanueli C, Salis MB, Linthout SV, Meloni M, Desortes E, Silvestre J, Clergue M, Figueroa CD, Gadau S, Condorelli G, Madeddu P. Akt/ protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer. Circulation. 2004;110:1638-1644.
18. Ferreira HH, Medeiros MV, Lima CS, Flores CA, Sannomiya P, Autunes E, Nucci GD. Inhibition of eosinophil chemotaxis by chronic blockade of nitric oxide biosynthesis. Eur J Pharmacol. 1996;310:201-207.
19. Madeddu P, Kraenkel N, Barcelos LS, Siragusa M, Campagnolo P, Oikawa A, Caporali A, Herman A, Azzolino O, Barberis L, Perino A, Damilano F, Emanueli C, Hirsch E. Phosphoinositide 3-kinase y gene knockout impairs post-ischemic neovascularization and endothelial progenitor cell functions. Arterioscler Thromb Vasc Biol. 2008;28:68-76.
20. Chavakis E, Carmona G, Urbich C, Gottig S, Henschler R, Penninger JM, Zeiher AM, Chavakis T, Dimmeler S. Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells. Circ Res. 2008;102:942-949.
21. Oh IY, Yoon CH, Hur J, Kim JH, Kim TY, Lee CS, Park KW, Chae IH, Oh BH, Park YB, Kim HS. Involvement of E-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle. Blood. 2007;110:3891-3899.
22. Niu J, Azfer A, Zhelyabovska O, Fatma S, Kolattukudy PE. Monocyte chemoattractant protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP). J Biol Chem. 2008;283:14542-14551.
23. Kawamoto A, Asahara T. Role of progenitor endothelial cells in cardiovascular disease and upcoming therapies. Catheter Cardiovasc Interv. 2007;70:477-484.
24. van Weel V, Seghers L, de Vries MR, Kuiper EJ, Schlingemann RO, Bajema IM, Lindeman JHN, Diemen PMD, van Hinsbergh VWM, van Bockel JH, Quax PHA. Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemia. Arterioscler Thromb Vasc Biol. 2007;27: 1426-1432.
25. Walter DH, Haendeler J, Reinhold J, Rochwalsky U, Seeger F, Honold J, Hoffmann J, Urbich C, Lehmann R, Arenzana-Seisdesdos F, Aicher A, Heeschen C, Fichtlscherer S, Zeiher AM, Dimmeler S. Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endo-thelial progenitor cells from patients with coronary artery disease. Circ Res. 2005;97:1142-1151.
26. Rafii S, Avecilla S, Shmelkov S, Shido K, Tejada R, Moore MAS, Heissig B, Hattori K. Angiogenic factors reconstitute hematopoiesis by recruiting stem cells from bone marrow microenvironment. Ann N Y Acad Sci. 2003;996:49-60.
27. Tschöpe C, Walther T, Escher F, Spillmann F, Du J, Altmann C, Schimke I, Bader M, Sanchez-Ferrer CF, Schultheiss HP, Noutsias M. Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy. FASEB J. 2005;19:2057-2059.
28. Emanueli C, Minasi A, Zacheo A, Chao J, Chao L, Salis MB, Straino S, Tozzi MG, Smith R, Gaspa L, Bianchini G, Stillo F, Capogrossi MC, Madeddu P. Local delivery of human tissue kallikrein gene accelerates spontaneous angiogenesis in mouse model of hindlimb ischemia. Circulation. 2001;103:125-132.
29. Porcu P, Emanueli C, Desortes E, Marongiu GM, Piredda F, Chao L, Chao J, Madeddu P. Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2004; 24:1104-1110.
30. Spillmann F, Graiani G, Linthout SV, Meloni M, Campesi I, Lagrasta C, Westermann D, Tschöpe C, Quaini F, Emanueli C, Madeddu P. Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium. Regen Med. 2006;1:235-254.
31. Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, Zeiher AM, Dimmeler S. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med. 2003;9:1370-1376.
32. Yu J, deMuinck ED, Zhuang Z, Drinane M, Kauser K, Rubanyi GM, Qian HS, Murata T, Escalante B, Sessa WC. Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proc Natl Acad Sci USA. 2005;102:10999-11004.
33. Ju H, Venema VJ, Marrero MB, Venema RC. Inhibitory interactions of the bradykinin B2 receptor with endothelial nitric-oxide synthase. J Biol Chem. 1998;273:24025-24029.
34. Murga C, Fukuhara S, Gutkind JS. A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt. J Biol Chem. 2000;275:12069-12073.
35. Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B. Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature. 2008;453:662-666.
36. Miura S, Matsuo Y, Saku K. Transactivation of KDR/Flk-1 by the B2 receptor induces tube formation in human coronary endothelial cells. Hypertension. 2003;41:1118-1123. (Pubitemid 36548613)
37. Bartunek J, Vanderheyden M, Vandekerckhove B, Mansour S, De Bruyne B, De Bondt P, Van Haute I, Lootens N, Heyndrickx G, Wijns W. Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safety. Circulation. 2005;112(suppl I):I-178-I-183.
38. Ahmadi H, Baharvand H, Ashtiani SK, Soleimani M, Sadeghian H, Ardekani JM, Mehrjerdi NZ, Kouhkan A, Namiri M, Madani-Civi M, Fattahi F, Shahverdi A, Dizaji AV. Safety analysis and improved cardiac function following local autologous transplantation of CD133( + ) enriched bone marrow cells after myocardial infarction. Curr Neurovasc Res. 2007;4:153-160.
39. Vöö S, Eggermann J, Dunaeva M, Ramakers-van Oosterhoud C, Waltenberger J. Enhanced functional response of CD133+ circulating progenitor cells in patients early after acute myocardial infarction. Eur Heart J. 2008;29:241-250.
40. Wojakowski W, Tendera M, Michałowska A, Majka M, Kucia M, Maslankiewicz K, Wyderka R, Ochała A, Ratajczak MZ. Mobilization of CD34/CXCR4 +, CD34/CD117 +, c-met+ stem cells, and mononuclear cells expressing early cardiac, muscle, and endothelial markers into peripheral blood in patients with acute myocardial infarction. Circulation. 2004;110:3213-3220.