New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74

Human Vaccines and Immunotherapeutics

Volumn 11, Issue 5, 2015, Pages 1251-1257

  Pearson, Mark S ^a   Jariwala, Amar R ^b   Abbenante, Giovanni ^c   Plieskatt, Jordan ^b   Wilson, David ^a   Bottazzi, Maria Elena ^d   Hotez, Peter J ^d   Keegan, Brian ^d   Bethony, Jeffrey M ^b   Loukas, Alex ^a  

^a JAMES COOK UNIVERSITY   (Australia)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c BMG Labtech   (Australia)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Aspartic protease; Fluorescence polarization; Hookworm; Necator americanus; Vaccine

Indexed keywords

CATHEPSIN D; IMMUNOGLOBULIN G; NECATOR AMERICANUS ASPARTIC PROTEASE 1 M74; PEPSTATIN; UNCLASSIFIED DRUG; VACCINE; ALUMINUM HYDROXIDE; ASPARTIC PROTEINASE; HELMINTH ANTIBODY; IMMUNOLOGICAL ADJUVANT; MUTANT PROTEIN; NEUTRALIZING ANTIBODY; PARASITE ANTIGEN; RECOMBINANT PROTEIN; RECOMBINANT VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG CROSS REACTIVITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE POLARIZATION; IC50; IMMUNIZATION; MICROPLATE READER; MOUSE; NEGLECTED DISEASE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; QUALITY CONTROL; VACCINATION; VACCINE PRODUCTION; ANCYLOSTOMA; ANCYLOSTOMIASIS; ANIMAL; BAGG ALBINO MOUSE; BLOOD; DRUG DEVELOPMENT; ENZYMOLOGY; GENETICS; HOOKWORM INFECTIONS; IMMUNOLOGY; METABOLISM; PROCEDURES; TOBACCO; TRANSGENIC PLANT;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANCYLOSTOMA; ANCYLOSTOMIASIS; ANIMALS; ANTIBODIES, HELMINTH; ANTIBODIES, NEUTRALIZING; ANTIGENS, HELMINTH; ASPARTIC ACID PROTEASES; DRUG DISCOVERY; FEMALE; HOOKWORM INFECTIONS; MICE, INBRED BALB C; MUTANT PROTEINS; PLANTS, GENETICALLY MODIFIED; QUALITY CONTROL; RECOMBINANT PROTEINS; TOBACCO; VACCINES, SYNTHETIC;

EID: 84942422700     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.4161/21645515.2014.980199     Document Type: Article

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