Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR

PLoS Neglected Tropical Diseases

Volumn 6, Issue 1, 2012, Pages

  Soukhathammavong, Phonepasong Ayé ^a,b,c   Sayasone, Somphou ^a   Phongluxa, Khampheng ^a,b,c   Xayaseng, Vilavanh ^a   Utzinger, Jürg ^b,c   Vounatsou, Penelope ^b,c   Hatz, Christoph ^b,c,d   Akkhavong, Kongsap ^a   Keiser, Jennifer ^b,c   Odermatt, Peter ^b,c  

^a Ministry of Health   (Laos)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; MEBENDAZOLE; ANTHELMINTIC AGENT;

ABSENCE OF SIDE EFFECTS; ARTICLE; CHILD; FECES ANALYSIS; FEMALE; FOLLOW UP; HELMINTHIASIS; HOOKWORM INFECTION; HUMAN; LAOS; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; OPEN STUDY; OPISTHORCHIASIS; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SINGLE DRUG DOSE; TREATMENT OUTCOME; ANIMAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FECES; PARASITE IDENTIFICATION; PARASITOLOGY;

ALBENDAZOLE; ANIMALS; ANTHELMINTICS; CHILD; FECES; FEMALE; HOOKWORM INFECTIONS; HUMANS; LAOS; MALE; MEBENDAZOLE; OPISTHORCHIASIS; PARASITE EGG COUNT; TREATMENT OUTCOME;

EID: 84856583152     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001417     Document Type: Article

References (42)

1. Bethony J, Brooker S, Albonico M, Geiger SM, Loukas A, et al. (2006) Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. Lancet 367: 1521-1532.
2. Hotez PJ, Bottazzi ME, Franco-Paredes C, Ault SK, Periago MR, (2008) The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination. PLoS Negl Trop Dis 2: e300.
3. Keiser J, Utzinger J, (2010) The drugs we have and the drugs we need against major helminth infections. Adv Parasitol 73: 197-230.
4. WHO (2010) Soil-transmitted helminthiasis. Number of children treated 2007-2008: update on the 2010 global target. Wkly Epidemiol Rec 85: 141-148.
5. Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Buss P, (2005) Hookworm: "the great infection of mankind". PLoS Med 2: e67.
6. Brooker S, Hotez PJ, Bundy DAP, (2008) Hookworm-related anaemia among pregnant women: a systematic review. PLoS Negl Trop Dis 2: e291.
7. Smith JL, Brooker S, (2010) Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review. Trop Med Int Health 15: 776-795.
8. WHO (2002) Prevention and control of schistosomiasis and soil-transmitted helminthiasis: report of a WHO expert committee. WHO Tech Rep Ser 912: 1-57.
9. WHO (2006) Preventive chemotherapy in human helminthiasis. Coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers Geneva World Health Organization pp. 1-62.
10. Keiser J, Utzinger J, (2008) Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299: 1937-1948.
11. Montresor A, Cong DT, Sinuon M, Tsuyuoka R, Chanthavisouk C, et al. (2008) Large-scale preventive chemotherapy for the control of helminth infection in Western Pacific countries: six years later. PLoS Negl Trop Dis 2: e278.
12. Phommasack B, Saklokham K, Chanthavisouk C, Nakhonesid-Fish V, Strandgaard H, et al. (2008) Coverage and costs of a school deworming programme in 2007 targeting all primary schools in Lao PDR. Trans R Soc Trop Med Hyg 102: 1201-1206.
13. Kounnavong S, Vonglokham M, Houamboun K, Odermatt P, Boupha B, (2011) Soil-transmitted helminth infections and risk factors in preschool children in southern rural Lao People's Democratic Republic. Trans R Soc Trop Med Hyg 105: 160-166.
14. Forrer A, Sayasone S, Vounatsou P, Vonghachack V, Bouakhasith D, et al. (2011) Spatial distribution of, and risk factors for, Opisthorchis viverrini infection in southern Lao PDR. PLoS Negl Trop Dis In press.
15. Rim HJ, Chai JY, Min DY, Cho SY, Eom KS, et al. (2003) Prevalence of intestinal parasite infections on a national scale among primary schoolchildren in Laos. Parasitol Res 91: 267-272.
16. Sayasone S, Odermatt P, Phoumindr N, Vongsaravane X, Sensombath V, et al. (2007) Epidemiology of Opisthorchis viverrini in a rural district of southern Lao PDR. Trans R Soc Trop Med Hyg 101: 40-47.
17. Sayasone S, Mak TK, Vanmany M, Rasphone O, Vounatsou P, et al. (2011) Helminth and intestinal protozoa infections, multiparasitism and risk factors in Champasack province, Lao People's Democratic Republic. PLoS Negl Trop Dis 5: e1037.
18. Keiser J, Utzinger J, (2004) Chemotherapy for major food-borne trematodes: a review. Expert Opin Pharmacother 5: 1711-1726.
19. Pungpark S, Bunnag D, Harinasuta T, (1984) Albendazole in the treatment of opisthorchiasis and concomitant intestinal helminthic infections. Southeast Asian J Trop Med Public Health 15: 44-50.
20. Steinmann P, Utzinger J, Du ZW, Jiang JY, Chen JX, et al. (2011) Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS One 6: e25003.
21. MOH (2004) Diagnosis and treatment at the district. A diagnosis and treatment guideline for the district hospital in Lao PDR Vientiane Ministry of Health.
22. Sayasone S, Vonghajack Y, Vanmany M, Rasphone O, Tesana S, et al. (2009) Diversity of human intestinal helminthiasis in Lao PDR. Trans R Soc Trop Med Hyg 103: 247-254.
23. Katz N, Chaves A, Pellegrino J, (1972) A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop Sâo Paulo 14: 397-400.
24. Maleewong W, Intapan P, Wongwajana S, Sitthithaworn P, Pipitgool V, et al. (1992) Prevalence and intensity of Opisthorchis viverrini in a rural community near the Mekong River on the Thai-Laos border in northeast Thailand. J Med Assoc Thai 75: 231-235.
25. WHO (1995) Control of foodborne trematode infection: report of a WHO study group. WHO Tech Rep Ser 891: 1-157.
26. Olsen A, Namwanje H, Nejsum P, Roepstorff A, Thamsborg SM, (2009) Albendazole and mebendazole have low efficacy against Trichuris trichiura in school-age children in Kabale district, Uganda. Trans R Soc Trop Med Hyg 103: 443-446.
27. Albonico M, Bickle Q, Ramsan M, Montresor A, Savioli L, et al. (2003) Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar. Bull World Health Organ 81: 343-352.
28. Flohr C, Tuyen LN, Lewis S, Minh TT, Campbell J, et al. (2007) Low efficacy of mebendazole against hookworm in Vietnam: two randomized controlled trials. Am J Trop Med Hyg 76: 732-736.
29. Traub RJ, Inpankaew T, Sutthikornchai C, Sukthana Y, Thompson RC, (2008) PCR-based coprodiagnostic tools reveal dogs as reservoirs of zoonotic ancylostomiasis caused by Ancylostoma ceylanicum in temple communities in Bangkok. Vet Parasitol 155: 67-73.
30. Jiraanankul V, Aphijirawat W, Mungthin M, Khositnithikul R, Rangsin R, et al. (2011) Incidence and risk factors of hookworm infection in a rural community of central Thailand. Am J Trop Med Hyg 84: 594-598.
31. Tarafder MR, Carabin H, Joseph L, Balolong E Jr, Olveda R, et al. (2010) Estimating the sensitivity and specificity of Kato-Katz stool examination technique for detection of hookworms, Ascaris lumbricoides and Trichuris trichiura infections in humans in the absence of a 'gold standard'. Int J Parasitol 40: 399-404.
32. Albonico M, Mathema P, Montresor A, Khakurel B, Reggi V, et al. (2007) Comparative study of the quality and efficacy of originator and generic albendazole for mass treatment of soil-transmitted nematode infections in Nepal. Trans R Soc Trop Med Hyg 101: 454-460.
33. Geerts S, Gryseels B, (2000) Drug resistance in human helminths: current situation and lessons from livestock. Clin Microbiol Rev 13: 207-222.
34. Wolstenholme AJ, Fairweather I, Prichard R, von Samson-Himmelstjerna G, Sangster NC, (2004) Drug resistance in veterinary helminths. Trends Parasitol 20: 469-476.
35. Prichard RK, (1990) Anthelmintic resistance in nematodes: extent, recent understanding and future directions for control and research. Int J Parasitol 20: 515-523.
36. James CE, Hudson AL, Davey MW, (2009) Drug resistance mechanisms in helminths: is it survival of the fittest? Trends Parasitol 25: 328-335.
37. Jaroonvesama N, Charoenlarp K, Cross JH, (1981) Treatment of Opisthorchis viverrini with mebendazole. Southeast Asian J Trop Med Public Health 12: 595-597.
38. Lovis L, Mak TK, Phongluxa K, Soukhathammavong P, Sayasone S, et al. (2009) PCR diagnosis of Opisthorchis viverrini and Haplorchis taichui infections in a Lao community in an area of endemicity and comparison of diagnostic methods for parasitological field surveys. J Clin Microbiol 47: 1517-1523.
39. Tesana S, Srisawangwonk T, Kaewkes S, Sithithaworn P, Kanla P, et al. (1991) Eggshell morphology of the small eggs of human trematodes in Thailand. Southeast Asian J Trop Med Public Health 22: 631-636.
40. Xiao SH, Wu HM, Tanner M, Utzinger J, Wang C, (2005) Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop 94: 1-14.
41. Soukhathammavong P, Odermatt P, Sayasone S, Vonghachack Y, Vounatsou P, et al. (2011) Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial. Lancet Infect Dis 11: 110-118.
42. WHO (2008) Worldwide prevalence of anaemia 1993-2005 WHO global database on anemia. Geneva pp. 4-6.