Essential role of class II PI3K-C2α in platelet membrane morphology

Blood

Volumn 126, Issue 9, 2015, Pages 1128-1137

  Valet, Colin ^a   Chicanne, Gaëtan ^a   Severac, Childerick ^b,c   Chaussade, Claire ^d   Whitehead, Maria A ^d   Cabou, Cendrine ^a   Gratacap, Marie Pierre ^a   Gaits Iacovoni, Frederique ^a   Vanhaesebroeck, Bart ^d   Payrastre, Bernard ^a,e   Severin, Sonia ^a  

^a Université de Toulouse   (France)

^b UPS   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CLASS II PHOSPHATIDYLINOSITOL 3 KINASE C2ALPHA; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 3 KINASE; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3C2A PROTEIN, MOUSE; POLYPHOSPHOINOSITIDE;

ANIMAL CELL; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; CYTOSKELETON; ENZYME INACTIVATION; EX VIVO STUDY; FILOPODIUM; HETEROZYGOSITY; IN VIVO STUDY; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MEMBRANE STRUCTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; THROMBOCYTE MEMBRANE; THROMBOCYTOPOIESIS; THROMBOSIS; ANIMAL; C57BL MOUSE; CELL MEMBRANE; CYTOLOGY; GENE TARGETING; GENETICS; HETEROZYGOTE; LIPID METABOLISM; METABOLISM; MUTATION; PATHOLOGY; THROMBOCYTE; ULTRASTRUCTURE;

ANIMALS; BLOOD PLATELETS; CELL MEMBRANE; GENE KNOCK-IN TECHNIQUES; HETEROZYGOTE; LIPID METABOLISM; MICE; MICE, INBRED C57BL; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL PHOSPHATES; THROMBOPOIESIS;

EID: 84942411188     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-03-636670     Document Type: Article

References (39)

1. Di Paolo G, De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature. 2006;443(7112):651-657.
2. Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B. The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol. 2010;11(5):329-341.
3. Posor Y, Eichhorn-Gruenig M, Puchkov D, et al. Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate. Nature. 2013;499(7457):233-237.
4. Devereaux K, Dall'Armi C, Alcazar-Roman A, et al. Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. PLoS One. 2013;8(10):e76405.
5. Falasca M, Maffucci T. Regulation and cellular functions of class II phosphoinositide 3-kinases. Biochem J. 2012;443(3):587-601.
6. Fan CW, Chen B, Franco I, et al. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem Biol. 2014;21(12):1680-1689.
7. Franco I, Gulluni F, Campa CC, et al. PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function. Dev Cell. 2014;28(6):647-658.
8. Yoshioka K, Yoshida K, Cui H, et al. Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function. Nat Med. 2012;18(10):1560-1569.
9. Zhang J, Banfić H, Straforini F, Tosi L, Volinia S, Rittenhouse SE. A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate. J Biol Chem. 1998;273(23):14081-14084.
10. George JN. Platelets. Lancet. 2000;355(9214):1531-1539.
11. Hartwig JH. The platelet: form and function. Semin Hematol. 2006;43(1 Suppl 1):S94-S100.
12. Chang Y, Bluteau D, Debili N, Vainchenker W. From hematopoietic stem cells to platelets. J Thromb Haemost. 2007;5(Suppl 1):318-327.
13. Behnke O, Forer A. From megakaryocytes to platelets: platelet morphogenesis takes place in the bloodstream. Eur J Haematol Suppl. 1998;61:3-23.
14. Junt T, Schulze H, Chen Z, et al. Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007;317(5845):1767-1770.
15. Patel-Hett S, Wang H, Begonja AJ, et al. The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood. 2011;118(6):1641-1652.
16. Poirault-Chassac S, Nguyen KA, Pietrzyk A, et al. Terminal platelet production is regulated by von Willebrand factor. PLoS One. 2013;8(5):e63810.
17. Schwertz H, Köster S, Kahr WH, et al. Anucleate platelets genere progeny. Blood. 2010;115(18):3801-3809.
18. Thon JN, Italiano JE Jr. Does size matter in platelet production? Blood. 2012;120(8):1552-1561.
19. Thon JN, Macleod H, Begonja AJ, et al. Microtubule and cortical forces determine platelet size during vascular platelet production. Nat Commun. 2012;3:852.
20. Thon JN, Montalvo A, Patel-Hett S, et al. Cytoskeletal mechanics of proplatelet maturation and platelet release. J Cell Biol. 2010;191(4):861-874.
21. Severin S, Gaits-Iacovoni F, Allart S, Gratacap MP, Payrastre B. A confocal-based morphometric analysis shows a functional crosstalk between the actin filament system and microtubules in thrombin-stimulated platelets. J Thromb Haemost. 2013;11(1):183-186.
22. Chicanne G, Severin S, Boscheron C, et al. A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples. Biochem J. 2012;447(1):17-23.
23. Giuriato S, Pesesse X, Bodin S, et al. SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochem J. 2003;376(Pt 1):199-207.
24. Hutter JL, Bechhoefer J. Calibration of atomic-force microscope tips. Rev Sci Instrum. 1993;64(7):1868-1873.
25. Sneddon IN. The relation between load and penetration in the axisymmetric problem for a punch of arbitrary profile. Int J Eng Sci. 1965;3(1):47-57.
26. Payrastre B. Phosphoinositides: lipid kinases and phosphatases. Methods Mol Biol. 2004;273:201-212.
27. Fox JE, Boyles JK. The membrane skeleton - a distinct structure that regulates the function of cells. BioEssays. 1988;8(1):14-18.
28. Italiano JE Jr. Unraveling mechanisms that control platelet production. Semin Thromb Hemost. 2013;39(1):15-24.
29. Hartwig J, Italiano J Jr. The birth of the platelet. J Thromb Haemost. 2003;1(7):1580-1586.
30. Thon JN, Italiano JE. Platelets: production, morphology and ultrastructure. Handb Exp Pharmacol.2012(210):3-22.
31. Mazza S, Maffucci T. Class II phosphoinositide 3-kinase C2alpha: what we learned so far. Int J Biochem Mol Biol. 2011;2(2):168-182.
32. De Matteis MA, Morrow JS. Spectrin tethers and mesh in the biosynthetic pathway. J Cell Sci. 2000;113(Pt 13):2331-2343.
33. Spinler KR, Shin JW, Lambert MP, Discher DE. Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia. Blood. 2015;125(3):525-533.
34. Catimel B, Kapp E, Yin MX, et al. The PI(3)P interactome from a colon cancer cell. J Proteomics. 2013;82:35-51.
35. Gunn-Moore FJ, Welh GI, Herron LR, et al. A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'. FEBS Lett. 2005;579(22):5089-5094.
36. Steimle PA, Hoffert JD, Adey NB, Craig SW. Polyphosphoinositides inhibit the interaction of vinculin with actin filaments. J Biol Chem. 1999;274(26):18414-18420.
37. Jean S, Cox S, Schmidt EJ, Robinson FL, Kiger A. Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. Mol Biol Cell. 2012;23(14):2723-2740.
38. Velichkova M, Juan J, Kadandale P, et al. Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions. J Cell Biol. 2010;190(3):407-425.
39. Mountford JK, Petitjean C, Putra HW, et al. The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nat Commun. 2015;6:6535.