The selective degradation of synaptic connexin 43 protein by hypoxia-induced autophagy impairs natural killer cell-mediated tumor cell killing

Journal of Biological Chemistry

Volumn 290, Issue 39, 2015, Pages 23670-23679

  Tittarelli, Andrés ^a   Janji, Bassam ^b   Van Moer, Kris ^b   Noman, Muhammad Zaeem ^a   Chouaib, Salem ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

BIOELECTRIC POTENTIALS; CYTOLOGY; DERMATOLOGY; ENZYME ACTIVITY; ONCOLOGY; TUMORS;

HYPOXIA-INDUCIBLE FACTOR 1; IMMUNE SURVEILLANCE; INTERCELLULAR COMMUNICATIONS; MICROENVIRONMENTS; NATURAL KILLER CELLS; SELECTIVE DEGRADATION; TRANSCRIPTIONAL ACTIVITY; TUMOR CELL KILLINGS;

CELLS;

CONNEXIN 43; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA;

ARTICLE; AUTOPHAGY; CANCER CELL; CELL COMMUNICATION; CELL HYPOXIA; CELL KILLING; CHANNEL GATING; CONTROLLED STUDY; CYTOLYSIS; GAP JUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; IMMUNOSURVEILLANCE; MELANOMA CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TUMOR MICROENVIRONMENT; APOPTOSIS; IMMUNOLOGY; MELANOMA; METABOLISM; NATURAL KILLER CELL; PATHOLOGY; PHYSIOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; CELL HYPOXIA; CELL LINE, TUMOR; CONNEXIN 43; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KILLER CELLS, NATURAL; MELANOMA; PROTEOLYSIS; TRANSCRIPTIONAL ACTIVATION;

EID: 84942362038     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.651547     Document Type: Article

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