Diversity of the Cytotoxic Melanoma-Specific Immune Response: Some CTL Clones Recognize Autologous Fresh Tumor Cells and Not Tumor Cell Lines

Journal of Immunology

Volumn 158, Issue 8, 1997, Pages 3787-3795

  Dufour, Evelyne ^a   Carcelain, Guislaine ^b   Gaudin, Catherine ^a   Flament, Caroline ^a   Avril, Marie Françoise ^c   Faure, Florence ^a,d  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c IGR   (France)

^d INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR ANTIGEN;

AGED; AMINO ACID SEQUENCE; ARTICLE; CASE REPORT; CELL CLONE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HUMAN; IMMUNOLOGY; MALE; MELANOMA; MOLECULAR GENETICS; PATHOLOGY; T LYMPHOCYTE SUBPOPULATION;

AGED; AMINO ACID SEQUENCE; ANTIGENS, NEOPLASM; CLONE CELLS; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; MALE; MELANOMA; MOLECULAR SEQUENCE DATA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031569521     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Coulie, P. G., V. Brichard, A. Van Pel, T. Wolfel, J. Schneider, C. Traversari, S. Mattei, E. De Plaen, C. Lurkin, J. P. Szikora, J. C. Renauld, and T. Boon. 1994. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA A2 melanoma. J. Exp. Med. 180:35.
2. Brichard, V., A. Van Pel, T. Wolfel, C. Wolfel, E. D. Plaen, B. Lethe, P. Coulie, and T. Boon. 1993. The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J. Exp. Med. 178:489.
3. Kawakami, Y., S. Eliyahu, C. H. Delgado, P. F. Robbins, K. Sakaguchi, E. Appella, J. R. Yannelli, G. J. Adema, T. Miki, and S. A. Rosenberg. 1994. Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc. Natl. Acad Sci. USA 91:6458.
4. Wang, R. F., P. F. Robbins, Y. Kawakami, X. Q. Kang, and S. A. Rosenberg. 1995. Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes. J. Exp. Med. 181:799.
5. Van der Bruggen, P., C. Traversari, P. Chomez, C. Lurquin, E. De Plaen, B. Van den Eynde, A. Knuth, and T. Boon. 1991. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643.
6. Gaugler, B., B. Van den Eynde, P. Van der Bruggen, P. Romero, J. J. Gaforio, E. de Plaen, B. Lethe, F. Brasseur, and T. Boon. 1994. Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous T lymphocytes. J. Exp. Med. 179:921.
7. Boel, P., C. Wildmann, M. L. Sensi, R. Brasseur, J. C. Renaud, P. Coulie, T. Boon, and P. Van der Bruggen. 1995. BAGE: a new gene encoding an antigen recognized on human melanoma by cytotoxic T lymphocytes. Immunity 2:167.
8. Van den Eynde, B., O. Peeters, O. De Backer, B. Gaugler, S. Lucas, and T. Boon. 1995. A new family of genes coding for an antigen recognized by autologous cytotoxic T lymphocytes on a human melanoma. J. Exp. Med. 182:689.
9. Guilloux Y., S. Lucas, V. Brichard, A. Van Pel, C. Viret, E. De Plaen, F. Brasseur, B. Lethé, and T. Boon. 1996. A peptide recognized by human cytotoxic T lymphocytes on HLA A2 melanomas is encoded by an intron sequence of the N-acetylglucosaminyltransferase V gene. J. Exp. Med. 183:1173.
10. INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269:1281.
11. Coulie, P. G., F. Lehmann, B. Lethé, J. Herman, C. Lurkin, M. Andrawiss, and T. Boon. 1995. A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma. Proc. Natl. Acad. Sci. USA 92:7976.
12. Skipper, J. C. A., R. C. Hendrickson, P. H. Gulden, V. Brichard, A. Van Pel, Y. Chen, J. Shabanowitz, T. Wolfel, C. L. Slingluff, T. Boon, D. F. Hunt, and V. H. Engelhard. 1996. An HLA A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing membrane proteins. J. Exp. Med. 183:527.
13. Sensi, M. L., and G. Parmiani. Analysis of TCR usage in human tumors: a new tool for assessing tumor-specific immune responses. Immunol. Today 16:588.
14. Ferradini, L., S. Roman-Roman, J. Azocar, M. F. Avril, F. Triebel, and T. Hercend. 1992. Analysis of T cell receptor α/β variability in lymphocytes infiltrating a melanoma metastasis. Cancer Res. 52:4649.
15. Ferradini, L., A. Mackensen, C. Genevée, J. Bosq, P. Duvillard, M. F. Avril, and T. Hercend. 1993. Analysis of T cell receptor variability in tumor-infiltrating lymphocytes from a human regressive melanoma. J. Clin. Invest. 91:1183.
16. Mackensen, A., L. Ferradini, G. Carcelain, F. Triebel, F. Faure, S. Viel, and T. Hercend. 1993. Evidence for in situ amplification of cytotoxic T-lymphocytes with antitumor activity in a human regressive melanoma. Cancer Res. 53:3569.
17. Mackensen, A., G. Carcelain, S. Viel, M. C. Raynal, H. Michalaki, F. Triebel, J. Bosq, and T. Hercend. 1994. Direct evidence to support the immunosurveillance concept in a human regressive melanoma. J. Clin. Invest. 93:1397.
18. Wolfel, T., E. Klehman, C. Muller, K. H. Scutt, K. H. Meyer zum Büschenfelde, and A. Knuth. 1989. Lysis of human melanoma cells by autologous cytolytic T cell clones. J. Exp. Med. 170:797.
19. Cox, A. L., J. Skipper, Y. Chen, R. A. Henderson, T. L. Darrow, J. Shabanowitz, V. H. Engelhard, D. F. Hunt, and C. L. Slingluff. 1994. Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science 264:716.
20. Kawakami, Y., S. Eliyahu, K. Sakaguchi, P. F. Robbins, L. Rivoltini, J. R. Yannelli, E. Appella, and S. A. Rosenberg. 1994. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA A2-restricted tumor-infiltrating lymphocytes. J. Exp. Med. 180:347.
21. G. Spagnoli, C. Schaefer, T. E. Willimann, T. Kocher, A. Amoroso, A. Juretic, M. Zuber, U. Luscher, F. Harder, and M. Heberer. 1995. Peptide-specific CTL in tumor-infiltrating lymphocytes from metastatic melanomas expressing MART-1/ Melan A, gp100 and tyrosinase genes: a study in an unselected group of HLA A2.I positive patients. Int. J. Cancer 64:309.
22. Degiovanni, G., P. Hainaut, T. Lahaye, P. Weynants, and T. Boon. 1990. Antigens recognized on a melanoma cell line by autologous cytolytic T lymphocytes are also expressed on freshly collected tumor cells. Eur. J. Immunol. 20:1865.
23. Anichini, A., R. Mortarini, C. Maccalli, P. Squarcina, K. Fleischhauer, L. Mascheroni, and G. Parmiani. 1996. Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA A2.1-restricted immune repertoire to melanoma. J. Immunol. 156:208.
24. Maeurer, M. J., S. M. Gollin, D. Martin, W. Swaney, J. Bryant, C. Castelli, P. Robbins, G. Parmiani, W. J. Storkus, and M. T. Lotze. 1996. Tumor escape from immune recognition. J. Clin. Invest. 98:1633.
25. Sharrock, C. E., E. Kaminski, and S. Man. 1990. Limiting dilution analysis of human T cells: a useful clinical tool. Immunol. Today 11:281.
26. Diu, A., F. Romagné, C. Genevée, C. Rocher, J. M. Bruneau, A. David, F. Praz, and T. Hercend. 1993. Fine specificity of monoclonal antibodies directed at human T cell receptor variable regions: comparison with oligonucleotide-driven amplification for evaluation of Vβ expression. Eur. J. Immunol. 23:1422.
27. Genevée, C., A. Diu, J. Nierat, A. Caignard, P. Y. Dietrich, L. Ferradini, S. Roman-Roman, F. Triebel, and T. Hercend. 1992. An experimentally validated sub-family specific oligonucleotide primers (Vα1-w29/Vβ1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur. J. Immunol. 22:1261.
28. Even, J., A. Lim, I. Puisieux, L. Ferradini, P. Y. Dietrich, A. Toubert, T. Hercend, F. Triebel, C. Pannetier, and P. Kourilsky. 1995. T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β chain CDR3 size determination: evidence for oligoclonal expansions in tumors and inflammatory diseases. Res. Immunol. 146:65.
29. Pannetier, C., M. Cochet, S. Darche, A. Casrouge, M. Zoller, and P. Kourilsky. 1993. The sizes of the CDR3 hypervariable regions of the murine T-cell receptor β chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA 90:4319.
30. Van der Bruggen, P., J. Bastin, T. Gajewski, C. Coulie, P. Boel, C. De Smet, C. Traversari, A. Townsend, and T. Boon. 1994. A peptide encoded by human gene MAGE-3 presented by HLA A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3. Eur. J. Immunol. 24:3038.
31. + cytotoxic T lymphocytes, J. Exp. Med. 181:363.
32. Kawakami, Y., S. Eliyahu, C. Jennings, K. Sakagushi, X. Kang, S. Southwood, P. F. Robbins, A. Sette, E. Appella, and S. A. Rosenberg. 1994. Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating lymphocytes associated with in vivo tumor regression. J. Immunol. 154:3961.
33. Wolfel, T., A. Van Pel, V. Brichard, J. Schneider, B. Seliger, K. H. Meyer zum Büschenfelde, and T. Boon. 1994. Two tyrosinase nonapeptides recognized by autologous cytolytic T lymphocytes. Eur. J. Immunol. 24:759.
34. Rivoltini, L., K. C. Barrachini, V. Viggioano, Y. Kawakami, A. Smith, A. Mixon, N. P. Restifio, S. Topalian, T. B. Simonis, S. A. Rosenberg, and F. M. Marincola. 1995. Quantitative correlation between HLA class I allele expression and recognition of melanoma cells by antigen-specific cytotoxic T lymphocytes. Cancer Res. 55:3149.
35. Cole, D. J., D. P. Weil, P. Shamamaian, L. Rivoltini, Y. Kawakami, S. Topalian, C. Jennings, S. Eliyahu, S. Rosenberg, and M. I. Nishimura. 1994. Identification of MART-1-specific T-cell receptors: T cells utilizing distinct T cell receptor variable and joining regions recognize the same tumor epitopes. Cancer Res. 54:5265.
36. Sensi, M. L., C. Castelli, C. Traversari, M. Radrizzani, S. Salvi, C. Maccalli, R. Mortarini, L. Rivoltini, C. Farina, G. Nicolini, T. Wolfel, V. Brichard, T. Boon, C. Bordignon, A. Anichinio, and G. Parmiani. 1995. Cytotoxic T lymphocyte clones from different patients display limited T-cell receptor variable-region gene usage in HLA A2-restricted recognition of the melanoma antigen Melan-A/MART-1. Proc. Natl. Acad. Sci. USA 92:5674.
37. Rivoltini, L., J. Loftus, K. Barracchini P. Arienti, A. Mazzocchi, W. E. Biddison, M. L. Salgaller, E. Appella, G. Parmiani, and F. M. Marincola. 1996. Binding and presentation of peptides derived from melanoma antigens MART-1 and glycoprotein 100 by HLA A2 subtypes. J. Immunol. 156:3882.
38. Gervoix N., Y. Guilloux, E. Diez, and F. Jotereau. 1996. Suboptimal activation of melanoma infiltrating lymphocyte (TIL) due to low avidity of TCR/MHC-tumor peptide interactions. J. Exp. Med. 183:2403.
39. Chen, Y. T., E. Stockert, A. Jungbluth, S. Tsang, K. A. Coplan, M. J. Scanlan, and L. J. Old. 1996. Serological analysis of Melan-A (MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas. Proc. Natl. Acad. Sci. USA 93:5915.
40. Ferrone, S., and F. Marincola. 1995. Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance. Immunol. Today 16:487.
41. Rosenberg, S. A. 1996. Immunotherapy of patients with melanoma based on the genes encoding melanoma antigens. Proc. Am. Assoc. Cancer Res. 37:642.