Interleukin-8 Induces Expression of FOXC1 to Promote Transactivation of CXCR1 and CCL2 in Hepatocellular Carcinoma Cell Lines and Formation of Metastases in Mice

Gastroenterology

Volumn 149, Issue 4, 2015, Pages 1053-1067.e14

  Huang, Wenjie ^a,b   Chen, Zhangqian ^a   Zhang, Lin ^a   Tian, Dean ^b   Wang, Daowen ^b   Fan, Daiming ^a   Wu, Kaichun ^a   Xia, Limin ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Chemokine (C C Motif) Ligand 2; Chemokine (C X C Motif) Receptor 1; Liver Cancer; Mouse Model

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FOXC1; AUTACOID; CCL2 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXC1 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; IL8 PROTEIN, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INFILTRATION; CANCER PATIENT; CANCER RECURRENCE; CANCER SIZE; CCL2 GENE; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CXCR1 GENE; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; LIVER CELL CARCINOMA; LIVER METASTASIS; LUNG METASTASIS; MACROPHAGE MIGRATION; MAJOR CLINICAL STUDY; MALE; METASTASIS; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION; SURVIVAL TIME; TRANSACTIVATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR INVASION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BINDING SITE; CELL MOTION; COCULTURE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HEPG2 CELL LINE; IMMUNOLOGY; LIVER TUMOR; MACROPHAGE; METABOLISM; NUDE MOUSE; PATHOLOGY; RNA INTERFERENCE; SECONDARY; TIME; TRANSCRIPTION INITIATION;

ANIMALS; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; CHEMOKINE CCL2; COCULTURE TECHNIQUES; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION MEDIATORS; INTERLEUKIN-8; LIVER NEOPLASMS; MACROPHAGES; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; PHOSPHATIDYLINOSITOL 3-KINASE; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, INTERLEUKIN-8A; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 84942361015     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.05.058     Document Type: Article

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