Severity of malaria in relation to a complement receptor 1 polymorphism: A case-control study

Pathogens and Global Health

Volumn 109, Issue 5, 2015, Pages 247-252

  Tettey, Rebecca ^a   Ayeh Kumi, Patrick ^a   Tettey, Prudence ^a   Adjei, George O ^a   Asmah, Richard H ^b   Dodoo, Daniel ^c  

^a UNIVERSITY OF GHANA   (Ghana)

^b School of Biomedical and Allied Health Sciences   (Ghana)

^c University of Ghana   (Ghana)

Author keywords

Cerebral malaria; Complement receptor 1; McCoy; Severe malarial anaemia; Swain Langley

Indexed keywords

COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT RECEPTOR;

ANEMIA; ARTICLE; CASE CONTROL STUDY; CHILD; DISEASE SEVERITY; ERYTHROCYTE; FEMALE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPING TECHNIQUE; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALARIA; MALE; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; SCHOOL CHILD; GENETIC PREDISPOSITION; GENETICS; GHANA; IMMUNOLOGY; INFANT; PATHOLOGY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TREATMENT OUTCOME;

CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPING TECHNIQUES; GHANA; HUMANS; INFANT; MALARIA; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, COMPLEMENT; TREATMENT OUTCOME;

EID: 84942323959     PISSN: 20477724     EISSN: 20477732     Source Type: Journal    
DOI: 10.1179/2047773215Y.0000000011     Document Type: Article

References (27)

1. Aregawi M, Cibulskis RE, Otten M, Williams R. World malaria report 2009. Geneva: World Health Organization; 2009.
2. World Health Organization. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster. Trans R Soc Trop Med Hyg. 2000;94(1):1-90.
3. Waitumbi JN, Opollo MO, Muga RO, Misore AO, Stoute JA. Red cell surface changes and erythrophagocytosis in children with severe Plasmodium falciparum anemia. Blood. 2000;95(4): 1481-6.
4. Miller LH, Baruch DI, Marsh K, Doumbo OK. The pathogenic basis of malaria. Nature. 2002;415(6872):673-9.
5. Weatherall DJ, Miller LH, Baruch DI, Marsh K, Doumbo OK, Casals-Pascual C, et al. Malaria and the red cell. Hematol Am Soc Hematol Educ Program. 2002:35-57.
6. Rowe JA, Moulds JM, Newbold CI, Miller LH. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature. 1997;388(6639): 292-5.
7. Stoute JA, Odindo AO, Owuor BO, Mibei EK, Opollo MO, Waitumbi JN. Loss of red blood cell-complement regulatory proteins and increased levels of circulating immune complexes are associated with severe malarial anemia. J Infect Dis. 2003;187(3):522-5.
8. Thathy V, Moulds JM, Guyah B, Otieno W, Stoute JA. Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya. Malar J. 2005;4:54.
9. Zimmerman PA, Fitness J, Moulds JM, McNamara DT, Kasehagen LJ, Rowe JA, et al. CR1 Knops blood group alleles are not associated with severe malaria in the Gambia. Genes Immun. 2003;4(5):368-73.
10. Krych-Goldberg M, Atkinson JP. Structure-function relationships of complement receptor type 1. Immunol Rev. 2001;180: 112-22.
11. Roozendaal R, Carroll MC. Complement receptors CD21 and CD35 in humoral immunity. Immunol Rev. 2007;219:157-66.
12. Cserti CM, Dzik WH. The ABO blood group system and Plasmodium falciparum malaria. Blood. 2007;110(7):2250-8.
13. Tham WH, Wilson DW, Lopaticki S, Schmidt CQ, Tetteh-Quarcoo PB, Barlow PN, et al. Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand. Proc Natl Acad Sci USA. 2010;107(40): 17327-32.
14. Carlson J, Helmby H, Hill AV, Brewster D, Greenwood BM, Wahlgren M. Human cerebral malaria: association with eryth-rocyte rosetting and lack of anti-rosetting antibodies. Lancet. 1990;336(8729):1457-60.
15. Rowe A, Obeiro J, Newbold CI, Marsh K. Plasmodium falciparum rosetting is associated with malaria severity in Kenya. Infect Immun. 1995;63(6):2323-6.
16. Treutiger CJ, Hedlund I, Helmby H, Carlson J, Jepson A, Twumasi P, et al. Rosette formation in Plasmodium falciparum isolates and anti-rosette activity of sera from Gambians with cerebral or uncomplicated malaria. Am J Trop Med Hyg. 1992;46(5):503-10.
17. Moulds JM, Zimmerman PA, Doumbo OK, Kassambara L, Sagara I, Diallo DA, et al. Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1. Blood. 2001;97(9):2879-85.
18. Moulds JM, Kassambara L, Middleton JJ, Baby M, Sagara I, Guindo A, et al. Identification of complement receptor one (CR1) polymorphisms in West Africa. Genes Immun. 2000;1(5):325-9.
19. Kusi KA, Gyan BA, Goka BQ, Dodoo D, Obeng-Adjei G, Troye-Blomberg M, et al. Levels of soluble CD163 and severity of malaria in children in Ghana. Clin Vaccine Immunol. 2008;15(9):1456-60.
20. Moulds JM, Thomas BJ, Doumbo O, Diallo DA, Lyke KE, Plowe CV, et al. Identification of the Kna/Knb polymorphism and a method for Knops genotyping. Transfusion. 2004;44(2): 164-9.
21. Hochberg Y. A sharper Bonferroni procedure for multiple tests of significance. Biometrika. 1988;75(4):800-2.
22. Hansson HH, Kurtzhals JA, Goka BQ, Rodriques OP, Nkrumah FN, Theander TG, et al. Human genetic polymorphisms in the Knops blood group are not associated with a protective advantage against Plasmodium falciparum malaria in Southern Ghana. Malar J. 2013;12:400.
23. Rowe JA, Rogerson SJ, Raza A, Moulds JM, Kazatchkine MD, Marsh K, et al. Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates. J Immunol. 2000;165(11):6341-6.
24. Smith BO, Mallin RL, Krych-Goldberg M, Wang X, Hauhart RE, Bromek K, et al. Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor. Cell. 2002;108(6): 769-80.
25. Krych M, Clemenza L, Howdeshell D, Hauhart R, Hourcade D, Atkinson JP. Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis. J Biol Chem. 1994;269(18):13273-8.
26. Ghiran I, Klickstein L, Nicholson-Weller A. Mannan binding lectin binds complement receptor type 1 and augments IgG-stimulated phagocytosis. Immunopharmacology. 2000;49(1):3.
27. Klickstein LB., Barbashov SF, Liu T, Jack RM, Nicholson-Weller A. Complement receptor type 1 (CR1, CD35) is a receptor for C1q. Immunity. 1997;7(3):345-55.