Human genetic polymorphisms in the Knops blood group are not associated with a protective advantage against Plasmodium falciparum malaria in Southern Ghana

Malaria Journal

Volumn 12, Issue 1, 2013, Pages

  Hansson, Helle H ^a,b   Kurtzhals, Jørgen A ^a,b   Goka, Bamenla Q ^c   Rodriques, Onike P ^c   Nkrumah, Francis N ^d   Theander, Thor G ^a,b   Bygbjerg, Ib Christian ^a,b   Alifrangis, Michael ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^c KORLE BU TEACHING HOSPITAL   (Ghana)

^d University of Ghana   (Ghana)

Author keywords

Complement receptor 1; Knops; Plasmodium falciparum; Severe malaria

Indexed keywords

COMPLEMENT COMPONENT C3B RECEPTOR;

ADOLESCENT; ANEMIA; ARTICLE; BLOOD GROUP SYSTEM; BRAIN MALARIA; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENOTYPE; GHANA; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; NEWBORN; PRESCHOOL CHILD; SCHOOL CHILD; SERUM GROUP KNOPS SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; BLOOD GROUP ANTIGENS; CHILD; CHILD, PRESCHOOL; DISEASE RESISTANCE; FEMALE; GENE FREQUENCY; GENOTYPE; GENOTYPING TECHNIQUES; GHANA; HAPLOTYPES; HUMANS; INFANT; INFANT, NEWBORN; MALARIA, FALCIPARUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, COMPLEMENT 3B;

EID: 84887929783     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-12-400     Document Type: Article

References (35)

1. WHO, World Malaria Report 2011 Geneva: World Health Organization 2012
2. Rosetting: a new cytoadherence property of malaria-infected erythrocytes. David PH, Handunnetti SM, Leech JH, Gamage P, Mendis KN, Am J Trop Med Hyg 1988 38 289 297 3354764 (Pubitemid 18086108)
3. High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children. Doumbo OK, Thera MA, Kone AK, Raza A, Tempest LJ, Lyke KE, Plowe CV, Rowe JA, Am J Trop Med Hyg 2009 81 987 993 10.4269/ajtmh.2009.09-0406 19996426
4. Plasmodium falciparum rosetting is associated with malaria severity in Kenya. Rowe A, Obeiro J, Newbold CI, Marsh K, Infect Immun 1995 63 2323 2326 7768616
5. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Rowe JA, Moulds JM, Newbold CI, Miller LH, Nature 1997 388 292 295 10.1038/40888 9230440 (Pubitemid 27317975)
6. Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies. Carlson J, Helmby H, Hill AV, Brewster D, Greenwood BM, Wahlgren M, Lancet 1990 336 1457 1460 10.1016/0140-6736(90)93174-N 1979090
7. The human C3b receptor (CR1). Weiss L, Fischer E, Haeffner-Cavaillon N, Jouvin MH, Appay MD, Bariety J, Kazatchkine M, Adv Nephrol Necker Hosp 1989 18 249 269 2522267
8. Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21). Ahearn JM, Fearon DT, Adv Immunol 1989 46 183 219 2551147 (Pubitemid 19254752)
9. Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene. An example of concerted (horizontal) evolution within a gene. Hourcade D, Miesner DR, Bee C, Zeldes W, Atkinson JP, J Biol Chem 1990 265 974 980 2295627
10. Genomic determination of the CR1 (CD35) density polymorphism on erythrocytes using polymerase chain reaction amplification and HindIII restriction enzyme digestion. Cornillet P, Philbert F, Kazatchkine MD, Cohen JH, J Immunol Methods 1991 136 193 197 10.1016/0022-1759(91)90006-2 1671871
11. Analysis of complement receptor type 1 (CR1) expression on erythrocytes and of CR1 allelic markers in Caucasian and African American populations. Herrera AH, Xiang L, Martin SG, Lewis J, Wilson JG, Clin Immunol Immunopathol 1998 87 176 183 10.1006/clin.1998.4529 9614933 (Pubitemid 28235139)
12. Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibility. Rowe JA, Raza A, Diallo DA, Baby M, Poudiougo B, Coulibaly D, Cockburn IA, Middleton J, Lyke KE, Plowe CV, Doumbo OK, Moulds JM, Genes Immun 2002 3 497 500 10.1038/sj.gene.6363899 12486610 (Pubitemid 41662108)
13. Hot spots in the red cell membrane: molecular aspects of some red cell antigens. Daniels G, Immunol Invest 1995 24 199 212 10.3109/08820139509062773 7713583
14. Identification of human erythrocyte blood group antigens on the C3b/C4b receptor. Rao N, Ferguson DJ, Lee SF, Telen MJ, J Immunol 1991 146 3502 3507 1827486
15. Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates. Rowe JA, Rogerson SJ, Raza A, Moulds JM, Kazatchkine MD, Marsh K, Newbold CI, Atkinson JP, Miller LH, J Immunol 2000 165 6341 6346 11086071
16. Identification of complement receptor one (CR1) polymorphisms in West Africa. Moulds JM, Kassambara L, Middleton JJ, Baby M, Sagara I, Guindo A, Coulibaly S, Yalcouye D, Diallo DA, Miller L, Doumbo O, Genes Immun 2000 1 325 329 10.1038/sj.gene.6363676 11196694
17. Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya. Thathy V, Moulds JM, Guyah B, Otieno W, Stoute JA, Malar J 2005 4 54 10.1186/1475-2875-4-54 16277654 (Pubitemid 41772407)
18. Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon. Fontes AM, Kashima S, Bonfim-Silva R, Azevedo R, Abraham KJ, Albuquerque SR, Bordin JO, Junior DM, Covas DT, Genet Mol Biol 2011 34 539 545 10.1590/S1415-47572011005000051 22215954
19. Identification of the Kna/Knb polymorphism and a method for Knops genotyping. Moulds JM, Thomas BJ, Doumbo O, Diallo DA, Lyke KE, Plowe CV, Rowe JA, Birmingham DJ, Transfusion 2004 44 164 169 10.1111/j.1537-2995.2004.00615.x 14962306 (Pubitemid 38236377)
20. Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1. Moulds JM, Zimmerman PA, Doumbo OK, Kassambara L, Sagara I, Diallo DA, Atkinson JP, Krych-Goldberg M, Hauhart RE, Hourcade DE, McNamara DT, Birmingham DJ, Rowe JA, Moulds JJ, Miller LH, Blood 2001 97 2879 2885 10.1182/blood.V97.9.2879 11313284
21. Expansion of the Knops blood group system and subdivision of Sl(a). Moulds JM, Zimmerman PA, Doumbo OK, Diallo DA, Atkinson JP, Krych-Goldberg M, Hourcade DE, Moulds JJ, Transfusion 2002 42 251 256 10.1046/j.1537-2995.2002. 00002.x 11896343
22. KAM: A new allele in the Knops blood group system. Moulds JM, Pierce S, Peck KB, Tulley ML, Doumbo O, Moulds JJ, Transfusion 2005 45 27A 82 040F
23. Molecular analysis of the York antigen of the Knops blood group system. Veldhuisen B, Ligthart PC, Vidarsson G, Roels I, Folman CC, van der Schoot CE, De HM, Transfusion 2011 51 1389 1396 10.1111/j.1537-2995.2010.02999.x 21214579
24. CR1 Knops blood group alleles are not associated with severe malaria in the Gambia. Zimmerman PA, Fitness J, Moulds JM, McNamara DT, Kasehagen LJ, Rowe JA, Hill AV, Genes Immun 2003 4 368 373 10.1038/sj.gene.6363980 12847553 (Pubitemid 38961145)
25. Genome-wide and fine-resolution association analysis of malaria in West Africa. Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, et al. Nat Genet 2009 41 657 665 10.1038/ng.388 19465909
26. Reid ME, Lomas-Francis C, Olsson M, The Blood Group Antigen FactsBook London, UK: Elsevier Academic Press 3 2012
27. Knops blood group haplotypes among distinct Brazilian populations. Covas DT, de Oliveira FS, Rodrigues ES, Abe-Sandes K, Silva WA Jr, Fontes AM, Transfusion 2007 47 147 153 10.1111/j.1537-2995.2007.01077.x 17207243 (Pubitemid 46006322)
28. Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum-infected erythrocytes. Garred P, Nielsen MA, Kurtzhals JA, Malhotra R, Madsen HO, Goka BQ, Akanmori BD, Sim RB, Hviid L, Infect Immun 2003 71 5245 5253 10.1128/IAI.71.9.5245-5253.2003 12933871 (Pubitemid 37070771)
29. Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria. Kurtzhals JA, Adabayeri V, Goka BQ, Akanmori BD, Oliver-Commey JO, Nkrumah FK, Behr C, Hviid L, Lancet 1998 351 1768 1772 10.1016/S0140-6736(97)09439-7 9635949 (Pubitemid 28269187)
30. A simple salting out procedure for extracting DNA from human nucleated cells. Miller SA, Dykes DD, Polesky HF, Nucleic Acids Res 1988 16 1215 10.1093/nar/16.3.1215 3344216
31. Prevalence of CYP2B6 alleles in malaria-endemic populations of West Africa and Papua New Guinea. Mehlotra RK, Ziats MN, Bockarie MJ, Zimmerman PA, Eur J Clin Pharmacol 2006 62 267 275 10.1007/s00228-005-0092-9 16506047
32. Court M, Court Lab Calculator 2008 http://www.tufts.edu/
33. Circulating immune complex levels are associated with disease severity and seasonality in children with malaria from Mali. Thomas BN, Diallo DA, Noumsi GT, Moulds JM, Biomark Insights 2012 7 81 86 22837639
34. Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria. Tetteh-Quarcoo PB, Schmidt CQ, Tham WH, Hauhart R, Mertens HD, Rowe A, Atkinson JP, Cowman AF, Rowe JA, Barlow PN, PLoS One 2012 7 34820 10.1371/journal.pone. 0034820 22506052
35. Knops blood group polymorphism and susceptibility to Mycobacterium tuberculosis infection. Noumsi GT, Tounkara A, Diallo H, Billingsley K, Moulds JJ, Moulds JM, Transfusion 2011 51 2462 2469 10.1111/j.1537-2995.2011.03161.x 21569042