CR1 Knops blood group alleles are not associated with severe malaria in the Gambia

Genes and Immunity

Volumn 4, Issue 5, 2003, Pages 368-373

  Zimmerman, Paz A ^a   Fitness, J ^b   Moulds, J M ^c   McNamara, D T ^a   Kasehagen, L J ^a   Rowe, J Alexandra ^d   Hill, A V S ^b,e  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

Blood groups; Complement receptor 1 (CR1); Evolution; Malaria; Single nucleotide polymorphisms

Indexed keywords

BLOOD GROUP ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT RECEPTOR; PRIMER DNA;

AFRICA; ALLELE; ARTICLE; BLOOD GROUP SYSTEM; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GAMBIA; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; NUCLEOTIDE SEQUENCE; PLASMODIUM FALCIPARUM; POPULATION RISK; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; AMINO ACID SEQUENCE; GENETIC PROCEDURES; GENETIC SELECTION; GENETICS; MOLECULAR GENETICS;

PLASMODIUM FALCIPARUM;

AMINO ACID SEQUENCE; BLOOD GROUP ANTIGENS; CASE-CONTROL STUDIES; DNA PRIMERS; GAMBIA; GENE FREQUENCY; HUMANS; MALARIA, FALCIPARUM; MOLECULAR PROBE TECHNIQUES; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, COMPLEMENT; SELECTION (GENETICS);

EID: 0346636688     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363980     Document Type: Article

References (40)

1. Carlson J et al. Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies. Lancet 1990; 336: 1457-1460.
2. Treutiger CJ et al. Rosette formation in Plasmodium falciparum isolates and anti-rosette activity of sera from Gambians with cerebral or uncomplicated malaria. Am J Trop Med Hyg 1992; 46: 503-510.
3. Newbold C et al. Receptor-specific adhesion and clinical disease in Plasmodium falciparum. Am J Trop Med Hyg 1997; 57: 389-398.
4. Heddini A et al. Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors. Infect Immun 2001; 69: 5849-5856.
5. Rowe A, Obeiro J, Newbold CI, Marsh K. Plasmodium falciparum rosetting is associated with malaria severity in Kenya. Infect Immun 1995; 63: 2323-2326.
6. Rowe JA, Shafi M, Kai O, Marsh K, Raza A. Nonimmune IgM but not IgG binds to the surface of Plasmodium falciparum infected erythrocytes and correlates with rosetting and severe malaria. Am J Trop Med Hyg (in press).
7. Ringwald P et al. Parasite virulence factors during falciparum malaria: rosetting, cytoadherence, and modulation of cytoadherence by cytokines. Infect Immun 1993; 61: 5198-5204.
8. Kun JF et al. Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambarene, Gabon. Trans R Soc Trop Med Hyg 1998; 92: 110-114.
9. al-Yaman F et al. Human cerebral malaria: lack of significant association between erythrocyte rosetting and disease severity. Trans R Soc Trop Med Hyg 1995; 89: 55-58.
10. Rogerson SJ et al. Cytoadherence characteristics of Plasmodium falciparum-infected erythrocytes from Malawian children with severe and uncomplicated malaria. Am J Trop Med Hyg 1999; 61: 467-472.
11. Scholander C, Treutiger CJ, Hultenby K, Wahlgren M. Novel fibrillar structure confers adhesive property to malaria-infected erythrocytes. Nat Med 1996; 2: 204-208.
12. Clough B, Atilola FA, Black J, Pasvol G. Plasmodium falciparum: the importance of IgM in the rosetting of parasite-infected erythrocytes. Exp Parasitol 1998; 89: 129-132.
13. Treutiger CJ, Carlson J, Scholander C, Wahlgren M. The time course of cytoadhesion, immunoglobulin binding, rosette formation, and serum-induced agglutination of Plasmodium falciparum-infected erythrocytes. Am J Trop Med Hyg 1998; 59: 202-207.
14. Somner EA, Black J, Pasvol G. Multiple human serum components act as bridging molecules in rosette formation by Plasmodium falciparum-infected erythrocytes. Blood 2000; 95: 674-682.
15. Baruch DI, Gormely JA, Ma C, Howard RJ, Pasloske BL. Plasmodium falciparum erythrocyte membrane protein 1 is a parasitized erythrocyte receptor for adherence to CD36, thrombospondin, and intercellular adhesion molecule 1. Proc Natl Acad Sci USA 1996; 93: 3497-3502.
16. Gardner JP, Pinches RA, Roberts DJ, Newbold CI. Variant antigens and endothelial receptor adhesion in Plasmodium falciparum. Proc Natl Acad Sci USA 1996; 93: 3503-3508.
17. Rowe JA, Moulds JM, Newbold CI, Miller LH. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature 1997; 388: 292-295.
18. Treutiger CJ, Heddini A, Fernandez V, Muller WA, Wahlgren M. PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes. Nat Med 1997; 3: 1405-1408.
19. Barragan A, Kremsner PG, Wahlgren M, Carlson J. Blood group A antigen is a coreceptor in Plasmodium falciparum rosetting. Infect Immun 2000; 68: 2971-2975.
20. Barragan A, Fernandez V, Chen Q, von Euler A, Wahlgren M, Spillmann D. The duffy-binding-like domain 1 of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a heparan sulfate ligand that requires 12 mers for binding. Blood 2000; 95: 3594-3599.
21. Moulds JM et al. Expansion of the Knops blood group system and subdivision of SI(a). Transfusion 2002; 42: 251-256.
22. Moulds JM, Zimmerman PA, Doumbo OK et al. Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1. Blood 2001; 97: 2879-2885.
23. Hill AV, Allsopp CE, Kwiatkowski D et al. Common west African HLA antigens are associated with protection from severe malaria. Nature 1991; 352: 595-600.
24. Moulds MK. Serological investigation and clinical significance of high-titer, low-avidity (HTLA) antibodies. Am J Med Technol 1981; 47: 789-795.
25. Moulds JM, Kassambara L, Middleton JJ et al. Identification of complement receptor one (CR1) polymorphisms in west Africa. Genes Immun 2000; 1: 325-329.
26. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 1989; 71: 441-459.
27. Brewster DR, Kwiatkowski D, White NJ. Neurological sequelae of cerebral malaria in children. Lancet 1990; 336: 1039-1043.
28. McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiatkowski D. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature 1994; 371: 508-510.
29. Birmingham DJ, Shen XP, Hourcade D, Nickells MW, Atkinson JP. Primary sequence of an alternatively spliced form of CR1. Candidate for the 75 000 M(r) complement receptor expressed on chimpanzee erythrocytes. J Immunol 1994; 153: 691-700.
30. Kumar S, Tamura K, Jakobsen IB, Nei M. MEGA2: Molecular Evolutionary Genetics Analysis Software, 2001.
31. McDonald JH, Kreitman M. Adaptive protein evolution at the Adh locus in Drosophila. Nature 1991; 351: 652-654.
32. Bellamy R, Kwiatkowski D, Hill AV. Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. Trans R Soc Trop Med Hyg 1998; 92: 312-316.
33. Herrera AH, Xiang L, Martin SG, Lewis J, Wilson JG. Analysis of complement receptor type 1 (CR1) expression on erythrocytes and of CR1 allelic markers in Caucasian and African American populations. Clin Immunol Immunopathol 1998; 87: 176-183.
34. Rowe JA, Raza A, Diallo DA et al. Erythrocyte complement receptor 1 expression levels do not correlate with a Hind III restriction fragment length polymorphism in Africans: implications for studies on malaria susceptibility. Genes Immun 2002; 3: 497-500.
35. Rowe JA, Rogerson SJ, Raza A et al. Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates. J Immunol 2000; 165: 6341-6346.
36. Sabeti PC, Reich DE, Higgins JM et al. Detecting recent positive selection in the human genome from haplotype structure. Nature 2002; 419: 832-837.
37. Krych-Goldberg M, Atkinson JP. Structure-function relationships of complement receptor type 1. Immunol Rev 2001; 180: 112-122.
38. Zimmerman PA, Buckler-White A, Alkhatib G et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med 1997; 3: 23-36.
39. Husain SM, Kalavathi P, Anandaraj MP. Analysis of sickle cell gene using polymerase chain reaction & restriction enzyme Bsu 361. Indian J Med Res 1995; 101: 273-276.
40. Rozas J, Rozas R. DnaSP version 3: an integrated program for molecular population genetics and molecular evolution analysis. Bioinformatics 1999; 15: 174-175.