Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor

Cell

Volumn 108, Issue 6, 2002, Pages 769-780

  Smith, Brian O ^a   Mallin, Rosie L ^a   Krych Goldberg, Malgorzata ^b   Wang, Xuefeng ^b   Hauhart, Richard E ^b   Bromek, Krystyna ^a   Uhrin, Dusan ^a   Atkinson, John P ^b   Barlow, Paul N ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C4B;

ANTIGEN BINDING; ARTICLE; BINDING SITE; COMPLEMENT ACTIVATION; IMMUNE ADHERENCE; IMMUNE RESPONSE; IMMUNOBIOLOGY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE;

EID: 0037155690     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00672-4     Document Type: Article

References (64)

1. Semi-constant-time HMSQC (SCT-HMSQC-HA) for the measurement of (3)J(HNH alpha) couplings in N-15-labeled proteins
2. 15N relaxation using inverse detected two dimensional NMR spectroscopy: The central helix is flexible
3. Solution structure of a pair of complement modules by nuclear magnetic resonance
4. Positively charged amino acids at the interface between alpha-chain CCP1 and CCP2 of C4BP are required for regulation of the classical C3-convertase
5. Structure and distribution of modules in extracellular proteins
6. Adhesion mechanism of human β2-glycoprotein I to phospholipids based on its crystal structure
7. Crystal structure of two CD46 domains reveals an extended measles virus-binding surface
8. Folding and conformational studies on SCR 1-3 domains of human complement receptor 1
9. Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines
10. Solution structure and dynamics of linked cell attachment modules of mouse fibronectin containing the RGD and synergy regions: Comparison with the human fibronectin crystal structure
11. Sequential protein backbone resonance assignments using an improved 3D-HN(CA)CO pulse scheme
12. Improved 3D triple-resonance NMR techniques applied to a 31-kDa protein
13. Solution structure and dynamics of the central CCP module pair of a poxvirus complement control protein
14. Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1
15. PROMOTIF - A program to identify and analyze structural motifs in proteins
16. 2 values in proteins
17. 2O samples of proteins
18. 2O saturation
19. Structure and flexibility of the multiple domain proteins that regulate complement activation
20. Independently melting modules and highly structured intermodular junctions within complement receptor type 1
21. Co-operativity between modules within a C3b-binding site of complement receptor type 1
22. Combining ultracentrifugation with fluorescence to follow the unfolding of modules 16-17 of complement receptor type 1
23. Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins
24. Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis
25. 1H 2D NMR spectra by interactive graphics
26. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
27. Sites within the complement C3b/C4b receptor important for the specificity of ligand binding
28. Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor, CD35) by substitution mutagenesis
29. Structure-function analysis of the active sites of complement receptor type 1
30. Structure-function relationships of complement receptor type 1
31. Decay accelerating activity of complement receptor type 1 (CD35)
32. Molecular modeling and mechanism of action of human decay-accelerating factor
33. Characterization of the active sites in decay-accelerating factor
34. Regulatory proteins of complement
35. Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46)
36. A general-method for assigning NMR-spectra of denatured proteins using 3D HC(CO)NH-TOCSY resonance experiments
37. Order matrix analysis of residual dipolar couplings using singular value decomposition
38. Improved sensitivity of HSQC spectra of exchanging protons at short interscan delays using a new fast HSQC (FHSQC) detection scheme that avoids water saturation
39. NMR study of rapidly exchanging backbone amide protons in staphylococcal nuclease and the correlation with structural and dynamic properties
40. Gradient enhanced triple resonance three-dimensional NMR experiments with improved sensitivity
41. Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans
42. The immune adherence phenomenon
43. Immune adherence
44. Automated NOESY interpretation with ambiguous distance restraints: The refined NMR solution structure of the pleckstrin homology domain from beta-spectrin
45. Identification of residues within the 727-767 segment of human complement component C3 important for its interaction with factor H and with complement receptor 1 (CR1, CD35)
46. Measurement of J and dipolar couplings from simplified two-dimensional NMR spectra
47. 2O
48. Gradient-tailored excitation for single-quantum NMR-spectroscopy of aqeous solutions
49. Structure-function relationships of the complement components
50. Quantitative analysis of C4Ab and C4Bb binding to the C3b/C4b receptor (CR1, CD35)
51. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
52. Mapping of the region of complement receptor (CR) 1 required for Plasmodium falciparum rosetting and demonstration of the importance of CR1 in rosetting in field isolates
53. Comparative protein modelling by satisfaction of spatial restraints
54. TROSY-type triple-resonance experiments for sequential NMR assignments of large proteins
55. Crystal structure of human β2-glycoprotein I: Implications for phospholipid binding and the antiphospholipid syndrome
56. Nonstochastic coexpression of activation receptors on murine natural killer cells
57. Substitution of two amino acids confers C3b binding to the C4 binding site of CR1 (CD35)
58. Structure of Complement Receptor 2 in complex with its C3d ligand
59. 3-TOCSY for resonance assignment of methyl-containing side chains in C-13-labeled proteins (2000)
60. Structural investigation of C4b-binding protein by molecular modeling: Localization of putative binding sites
61. Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis
62. NMR studies of a viral protein that mimics the regulators of complement activation
63. Proposed structure of the F' allotype of human CR1. Loss of a C3b binding site may be associated with altered function
64. Two-dimensional NMR experiments for correlating C-13-beta and H-1-delta/epsilon chemical-shifts of aromatic residues in C-13-labeled proteins via scalar couplings