Structure-functional characterization of cytochrome P450 Sterol 14α-Demethylase (CYP51B) from aspergillus fumigatus and molecular basis for the development of antifungal drugs

Journal of Biological Chemistry

Volumn 290, Issue 39, 2015, Pages 23916-23934

  Hargrove, Tatiana Y ^a   Wawrzak, Zdzislaw ^b   Lamb, David C ^c   Guengerich, F Peter ^a   Lepesheva, Galina I ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPERGILLUS; ENZYMES; FUNGI; GENES; SCAFFOLDS;

AMINO ACID SEQUENCE; ASPERGILLUS FUMIGATUS; FUNCTIONAL CHARACTERIZATION; FUNGAL INFECTION; NATURAL SUBSTRATES; STEADY STATE RATES; TREATMENT EFFICIENCY; X RAY CRYSTAL STRUCTURES;

ENZYME INHIBITION;

ANTIFUNGAL AGENT; BENZAMIDE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 STEROL 14ALPHA DEMETHYLASE CYP51B; LANOSTEROL; N [1 (2,4 DICHLOROPHENYL) 2 (1H IMIDAZOL 1 YL)ETHYL] 4 (5 PHENYL 1,3,4 OXADIAZOL 2 YL)BENZAMIDE; STEROL 14ALPHA DEMETHYLASE; STEROL 14ALPHA DEMETHYLASE INHIBITOR; UNCLASSIFIED DRUG; VORICONAZOLE; CYTOCHROME P-450 CYP51B, ASPERGILLUS; FUNGAL PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; ANTAGONISTS AND INHIBITORS; ANTIFUNGAL RESISTANCE; CATALYSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ASPERGILLUS FUMIGATUS; CATALYSIS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, FUNGAL; FUNGAL PROTEINS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VORICONAZOLE;

EID: 84942320248     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.677310     Document Type: Article

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