Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential

Heart Rhythm

Volumn 12, Issue 10, 2015, Pages 2186-2194

  Capel, Rebecca A ^a   Herring, Neil ^a   Kalla, Manish ^a   Yavari, Arash ^a   Mirams, Gary R ^b   Douglas, Gillian ^a   Bub, Gil ^a   Channon, Keith ^a   Paterson, David J ^a   Terrar, Derek A ^a   Burton, Rebecca Ann B ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Arrhythmia; Electrophysiology; Funny current; Heart failure; Heart rate; Hydroxychloroquine; Ion channels; Pacemaker

Indexed keywords

CALCIUM CHANNEL L TYPE; DELAYED RECTIFIER POTASSIUM CHANNEL; HYDROXYCHLOROQUINE; ENZYME INHIBITOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CALCIUM CURRENT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SAFETY; EXPERIMENTAL GUINEA PIG; HEART BEAT; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART RATE; HEART VENTRICLE FUNCTION; IN VITRO STUDY; IN VIVO STUDY; ION CURRENT; ISOLATED HEART; MALE; MOUSE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SINUS NODE; SINUS RHYTHM; ACTION POTENTIAL; ANIMAL; BRADYCARDIA; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ELECTROPHYSIOLOGY; GUINEA PIG; HEART ATRIUM; HEART FAILURE; PATCH CLAMP TECHNIQUE; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACTION POTENTIALS; ANIMALS; BRADYCARDIA; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGICAL PHENOMENA; ENZYME INHIBITORS; GUINEA PIGS; HEART ATRIA; HEART FAILURE; HEART RATE; HYDROXYCHLOROQUINE; MALE; MICE; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SINOATRIAL NODE;

EID: 84942292114     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2015.05.027     Document Type: Article

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