Central Nervous System and Peripheral Expression of CCL19, CCL21 and Their Receptor CCR7 in Experimental Model of Multiple Sclerosis

Archivum Immunologiae et Therapiae Experimentalis

Volumn 63, Issue 5, 2015, Pages 367-376

  Bielecki, Bartosz ^a,b   Jatczak Pawlik, Izabela ^a   Wolinski, Pawel ^a   Bednarek, Andrzej ^a   Glabinski, Andrzej ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Chemokine; Chemokine receptor; Experimental autoimmune encephalomyelitis; Neuroinflammation

Indexed keywords

CHEMOKINE RECEPTOR CCR7; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; CCR7 PROTEIN, MOUSE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN DETECTION; ARTICLE; BRAIN HOMOGENATE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEMALE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LYMPH NODE CELL; MACROPHAGE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REMISSION; RIBONUCLEASE PROTECTION ASSAY; SPLEEN CELL; ANIMAL; BRAIN; DISEASE COURSE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MONONUCLEAR CELL;

ANIMALS; BRAIN; CHEMOKINE CCL19; CHEMOKINE CCL21; DISEASE PROGRESSION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MULTIPLE SCLEROSIS; RECEPTORS, CCR7;

EID: 84942197538     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-015-0339-9     Document Type: Article

References (28)

1. Alt C, Laschinger M, Engelhardt B (2002) Functional expression of the lymphoid chemokines CCL19 (ELC) and CCL 21 (SLC) at the blood-brain barrier suggests their involvement in G-protein-dependent lymphocyte recruitment into the central nervous system during experimental autoimmune encephalomyelitis. Eur J Immunol 32:2133–2144
2. Bielecki B, Mazurek A, Wolinski P et al (2007) Expression of chemokine receptors CCR7 and CCR8 in the CNS during ChREAE. Scand J Immunol 66:383–392
3. Britschgi MR, Link A, Lissandrin TK et al (2008) Dynamic modulation of CCR7 expression and function on naive T lymphocytes in vivo. J Immunol 181:7681–7688
4. Columba-Cabezas S, Serafini B, Ambrosini E et al (2003) Lymphoid chemokines CCL19 and CCL21 are expressed in the central nervous system during experimental autoimmune encephalomyelitis: implications for the maintenance of chronic neuroinflammation. Brain Pathol 13:38–51
5. Comerford I, Nibbs RJ, Litchfield W et al (2010) The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses. Blood 116:4130–4140
6. Debes GF, Bonhagen K, Wolff T et al (2004) CC chemokine receptor 7 expression by effector/memory CD4+T cells depends on antigen specificity and tissue localization during influenza A virus infection. J Virol 78:7528–7535
7. Forster R, Davalos-Misslitz AC, Rot A (2008) CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol 8:362–371
8. Frohman EM, Racke MK, Raine CS (2006) Multiple sclerosis–the plaque and its pathogenesis. N Engl J Med 354:942–955
9. Glabinski AR, Tani M, Strieter RM et al (1997a) Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis. Am J Pathol 150:617–630
10. Glabinski AR, Tani M, Tuohy VK et al (1997b) Murine experimental autoimmune encephalomyelitis: a model of immune-mediated inflammation and multiple sclerosis. Methods Enzymol 288:182–190
11. Glabinski AR, Bielecki B, Kolodziejski P et al (2003a) TNF-alpha microinjection upregulates chemokines and chemokine receptors in the central nervous system without inducing leukocyte infiltration. J Interferon Cytokine Res 23:457–466
12. Glabinski AR, Bielecki B, Ransohoff RM (2003b) Chemokine upregulation follows cytokine expression in chronic relapsing experimental autoimmune encephalomyelitis. Scand J Immunol 58:81–88
13. Hulkower K, Brosnan CF, Aquino DA et al (1993) Expression of CSF-1, c-fms, and MCP-1 in the central nervous system of rats with experimental allergic encephalomyelitis. J Immunol 150:2525–2533
14. Kivisakk P, Mahad DJ, Callahan MK et al (2004) Expression of CCR7 in multiple sclerosis: implications for CNS immunity. Ann Neurol 55:627–638
15. Kroenke MA, Carlson TJ, Andjelkovic AV et al (2008) IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med 205:1535–1541
16. Krumbholz M, Theil D, Steinmeyer F et al (2007) CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions. J Neuroimmunol 190:72–79
17. Kuwabara T, Ishikawa F, Yasuda T et al (2009) CCR 7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells. J Immunol 183:2513–2521
18. Kuwabara T, Tanaka Y, Ishikawa F et al (2012) CCR7 ligands up-regulate IL-23 through PI3-kinase and NF-kappa B pathway in dendritic cells. J Leukoc Biol 92:309–318
19. Lassmann H, Bruck W, Lucchinetti C (2001) Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol Med 7:115–121
20. Ohl L, Mohaupt M, Czeloth N et al (2004) CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21:279–288
21. Parlato S, Santini SM, Lapenta C et al (2001) Expression of CCR-7, MIP-3beta, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities. Blood 98:3022–3029
22. Pashenkov M, Soderstrom M, Link H (2003) Secondary lymphoid organ chemokines are elevated in the cerebrospinal fluid during central nervous system inflammation. J Neuroimmunol 135:154–160
23. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
24. Ransohoff RM, Hamilton TA, Tani M et al (1993) Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis. FASEB J 7:592–600
25. Rappert A, Biber K, Nolte C et al (2002) Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl- current and chemotaxis in murine microglia. J Immunol 168:3221–3226
26. +regulatory T cells. J Exp Med 204:735–745
27. Serafini B, Rosicarelli B, Magliozzi R et al (2006) Dendritic cells in multiple sclerosis lesions: maturation stage, myelin uptake, and interaction with proliferating T cells. J Neuropathol Exp Neurol 65:124–141
28. + regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules. J Leukoc Biol 82:1230–1238