Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei

Cellular Microbiology

Volumn 17, Issue 10, 2015, Pages 1523-1535

  Bart, Jean Mathieu ^a,b   Cordon Obras, Carlos ^a   Vidal, Isabel ^a   Reed, Jennifer ^c   Perez Pastrana, Esperanza ^d   Cuevas, Laureano ^d   Field, Mark C ^e   Carrington, Mark ^c   Navarro, Miguel ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b Red de Investigación de Centros de Enfermedades Tropicales RICET Madrid   (Spain)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN L1; PEPTIDES AND PROTEINS; SERUM RESISTANCE ASSOCIATED PROTEIN; UNCLASSIFIED DRUG; APOL1 PROTEIN, HUMAN; HIGH DENSITY LIPOPROTEIN; MEMBRANE PROTEIN; PROTOZOAL PROTEIN; SERUM RESISTANCE ASSOCIATED PROTEIN, TRYPANOSOMA BRUCEI;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE CELL ANALYSIS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE; ANIMAL; CHEMISTRY; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM;

ANIMALS; APOLIPOPROTEINS; ENDOSOMES; HUMANS; LIPOPROTEINS, HDL; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MICROSCOPY, FLUORESCENCE; MICROSCOPY, IMMUNOELECTRON; PROTOZOAN PROTEINS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 84942195689     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/cmi.12454     Document Type: Article

References (31)

1. Allen, C.L., Goulding, D., and Field, M.C. (2003) Clathrin-mediated endocytosis is essential in Trypanosoma brucei. EMBO J 22: 4991-5002.
2. Barry, J.D. (1979) Capping of variable antigen on Trypanosoma brucei, and its immunological and biological significance. J Cell Sci 37: 287-302.
3. Bringaud, F., Robinson, D.R., Barradeau, S., Biteau, N., Baltz, D., and Baltz, T. (2000) Characterization and disruption of a new Trypanosoma brucei repetitive flagellum protein, using double-stranded RNA inhibition. Mol Biochem Parasitol 111: 283-297.
4. Caffrey, C.R., Hansell, E., Lucas, K.D., Brinen, L.S., Alvarez Hernandez, A., Cheng, J., etal. (2001) Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Mol Biochem Parasitol 118: 61-73.
5. Campillo, N., and Carrington, M. (2003) The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhodesiense. Mol Biochem Parasitol 127: 79-84.
6. Carrington, M., and Boothroyd, J. (1996) Implications of conserved structural motifs in disparate trypanosome surface proteins. Mol Biochem Parasitol 81: 119-126.
7. Cordon-Obras, C., Cano, J., Gonzalez-Pacanowska, D., Benito, A., Navarro, M., and Bart, J.M. (2013) Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity. PLoS ONE 8: e85072.
8. Cross, G.A. (1975) Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei. Parasitology 71: 393-417.
9. De Greef, C., and Hamers, R. (1994) The serum resistance-associated (SRA) gene of Trypanosoma brucei rhodesiense encodes a variant surface glycoprotein-like protein. Mol Biochem Parasitol 68: 277-284.
10. Engstler, M., Pfohl, T., Herminghaus, S., Boshart, M., Wiegertjes, G., Heddergott, N., and Overath, P. (2007) Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes. Cell 131: 505-515.
11. Grunfelder, C.G., Engstler, M., Weise, F., Schwarz, H., Stierhof, Y.D., Morgan, G.W., etal. (2003) Endocytosis of a glycosylphosphatidylinositol-anchored protein via clathrin-coated vesicles, sorting by default in endosomes, and exocytosis via RAB11-positive carriers. Mol Biol Cell 14: 2029-2040.
12. Higgins, M.K., Tkachenko, O., Brown, A., Reed, J., Raper, J., and Carrington, M. (2013) Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity. Proc Natl Acad Sci USA 110: 1905-1910.
13. Hirumi, H., and Hirumi, K. (1989) Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers. J Parasitol 75: 985-989.
14. Landeira, D., Bart, J.M., Van Tyne, D., and Navarro, M. (2009) Cohesin regulates VSG monoallelic expression in trypanosomes. J Cell Biol 186: 243-254.
15. Manna, P.T., Boehm, C., Leung, K.F., Natesan, S.K., and Field, M.C. (2014) Life and times: synthesis, trafficking, and evolution of VSG. Trends Parasitol 30: 251-258.
16. Oli, M.W., Cotlin, L.F., Shiflett, A.M., and Hajduk, S.L. (2006) Serum resistance-associated protein blocks lysosomal targeting of trypanosome lytic factor in Trypanosoma brucei. Eukaryot Cell 5: 132-139.
17. Pal, A., Hall, B.S., Jeffries, T.R., and Field, M.C. (2003) Rab5 and Rab11 mediate transferrin and anti-variant surface glycoprotein antibody recycling in Trypanosoma brucei. Biochem J 374: 443-451.
18. Pays, E., Vanhollebeke, B., Uzureau, P., Lecordier, L., and Pérez-Morga, D. (2014) The molecular arms race between African trypanosomes and humans. Nat Rev Microbiol 12: 575-584.
19. Penate, X., Lopez-Farfan, D., Landeira, D., Wentland, A., Vidal, I., and Navarro, M. (2009) RNA pol II subunit RPB7 is required for RNA pol I-mediated transcription in Trypanosoma brucei. EMBO Rep 10: 252-257.
20. Perez-Morga, D., Vanhollebeke, B., Paturiaux-Hanocq, F., Nolan, D.P., Lins, L., Homble, F., etal. (2005) Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. Science (New York, N.Y) 309: 469-472.
21. Stephens, N.A., and Hajduk, S.L. (2011) Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity. Eukaryot Cell 10: 1023-1033.
22. Sutterwala, S.S., Creswell, C.H., Sanyal, S., Menon, A.K., and Bangs, J.D. (2007) De novo sphingolipid synthesis is essential for viability, but not for transport of glycosylphosphatidylinositol-anchored proteins, in African trypanosomes. Eukaryot Cell 6: 454-464.
23. Thomson, R., and Finkelstein, A. (2015) Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis. Proc Natl Acad Sci USA 112: 2894-2899.
24. Thomson, R., Molina-Portela, P., Mott, H., Carrington, M., and Raper, J. (2009) Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes. Proc Natl Acad Sci USA 106: 19509-19514.
25. Turner, C.M., McLellan, S., Lindergard, L.A., Bisoni, L., Tait, A., and MacLeod, A. (2004) Human infectivity trait in Trypanosoma brucei: stability, heritability and relationship to sra expression. Parasitology 129: 445-454.
26. Uzureau, P., Uzureau, S., Lecordier, L., Fontaine, F., Tebabi, P., Homble, F., etal. (2013) Mechanism of Trypanosoma brucei gambiense resistance to human serum. Nature 501: 430-434.
27. Vanhamme, L., Paturiaux-Hanocq, F., Poelvoorde, P., Nolan, D.P., Lins, L., Van Den Abbeele, J., etal. (2003) Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature 422: 83-87.
28. Vanhollebeke, B., De Muylder, G., Nielsen, M.J., Pays, A., Tebabi, P., Dieu, M., etal. (2008) A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science (New York, N.Y) 320: 677-681.
29. Wirtz, E., Leal, S., Ochatt, C., and Cross, G.A. (1999) A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol Biochem Parasitol 99: 89-101.
30. Xong, H.V., Vanhamme, L., Chamekh, M., Chimfwembe, C.E., Van Den Abbeele, J., Pays, A., etal. (1998) A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense. Cell 95: 839-846.
31. Yeaman, C., Grindstaff, K.K., Wright, J.R., and Nelson, W.J. (2001) Sec6/8 complexes on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells. J Cell Biol 155: 593-604.