Endothelin type A receptor inhibition normalises intrarenal hypoxia in rats used as a model of type 1 diabetes by improving oxygen delivery

Diabetologia

Volumn 58, Issue 10, 2015, Pages 2435-2442

  Franzén, Stephanie ^a   Palm, Fredrik ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

BQ 123; Diabetic nephropathy; Endothelin type A receptor; Hypoxia; Kidney function; Rats

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN A RECEPTOR; OXYGEN; SODIUM; CYCLO(TRP-ASP-PRO-VAL-LEU); CYCLOPEPTIDE; ENDOTHELIN A RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOSE RESPONSE; DRUG BLOOD LEVEL; GLOMERULUS FILTRATION RATE; GLYCEMIC CONTROL; HYPOXEMIA; HYPOXIA; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY BLOOD FLOW; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY MEDULLA; KIDNEY PARENCHYMA; MALE; MAXIMUM DRUG EFFECT; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SODIUM URINE LEVEL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ULTRAFILTRATION; ANIMAL; ANOXIA; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DISEASE MODEL; DRUG EFFECTS; KIDNEY; KIDNEY CIRCULATION; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; ANOXIA; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; ENDOTHELIN A RECEPTOR ANTAGONISTS; KIDNEY; MALE; OXYGEN CONSUMPTION; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; RENAL CIRCULATION;

EID: 84942133759     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3690-9     Document Type: Article

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