DOPA and DHN pathway orchestrate melanin synthesis in Aspergillus species

Medical Mycology

Volumn 52, Issue 1, 2014, Pages 10-18

  Pal, Anuradha K ^a,b   Gajjar, Devarshi U ^a   Vasavada, Abhay R ^a  

^a ILADEVI CATARACT AND IOL RESEARCH CENTRE   (India)

^b MANIPAL UNIVERSITY   (India)

Author keywords

Aspergillus; DHN; DOPA; EPR; FTIR; melanin

Indexed keywords

1,8 NAPHTHALENEDIOL; AZO COMPOUND; DOPA; INTERNAL TRANSCRIBED SPACER; KOJIC ACID; MELANIN; NAPHTHALENE DERIVATIVE; PHTHALIDE DERIVATIVE; TRICYCLAZOLE; TROPOLONE; UNCLASSIFIED DRUG; 1,8-DIHYDROXYNAPHTHALENE; NAPHTHOL DERIVATIVE; SPACER DNA;

ARTICLE; ASPERGILLUS; ASPERGILLUS FLAVUS; ASPERGILLUS NIGER; ASPERGILLUS SYDOWII; ASPERGILLUS TAMARII; ASPERGILLUS TERREUS; ASPERGILLUS TUBINGENSIS; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; FUNGAL BIOMASS; FUNGUS CULTURE; GENE SEQUENCE; INFRARED SPECTROSCOPY; MELANOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SPECIES DIFFERENCE; ULTRAVIOLET SPECTROSCOPY; BIOSYNTHESIS; CHEMISTRY; CLASSIFICATION; DNA SEQUENCE; GENETICS; METABOLISM; MOLECULAR GENETICS; SPECTROSCOPY;

ASPERGILLUS; DIHYDROXYPHENYLALANINE; DNA, INTERGENIC; MELANINS; METABOLIC NETWORKS AND PATHWAYS; MOLECULAR SEQUENCE DATA; NAPHTHOLS; SEQUENCE ANALYSIS, DNA; SPECTRUM ANALYSIS;

EID: 84942093527     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693786.2013.826879     Document Type: Article

References (48)

1. Klich MA. Health effects of Aspergillus in food and air. Toxicol Ind Health 2009; 25: 657-667.
2. Denning DW. Invasive aspergillosis. Clin Infect Dis 1998; 26: 781-803.
3. Andriole VT. Infections with Aspergillus species. Clin Infect Dis 1993; 17 (Suppl. 2): S481-486.
4. Shukla PK, Kumar M, Keshava GB. Mycotic keratitis: an overview of diagnosis and therapy. Mycoses 2008; 51: 183-199.
5. Hogan LH, Klein BS, Levitz SM. Virulence factors of medically important fungi. Clin Microbiol Rev 1996; 9: 469-488.
6. Wheeler MH, Bell AA. Melanins and their importance in pathogenic fungi. Curr Top Med Mycol 1988; 2: 338-387.
7. Hill HZ. The function of melanin or six blind people examine an elephant. Bioessays 1992; 14: 49-56.
8. Henson JM, Butler MJ, Day AW. The dark side of the mycelium: melanins of Phytopathogenic Fungi. Annu Rev Phytopathol 1999; 37: 447-471.
9. Jacobson ES. Pathogenic roles for fungal melanins. Clin Micro-biol Rev 2000; 13: 708-717.
10. Rosas AL, Casadevall A. Melanization decreases the susceptibility of Cryptococcus neoformans to enzymatic degradation. Mycopathologia 2001; 151: 53-56.
11. Kaliszan R, Kaliszan A, Wainer IW. Prediction of drug binding to melanin using a melanin-based high-performance liquid chro-matographic stationary phase and chemometric analysis of the chromatographic data. J Chromatogr 1993; 615: 281-288.
12. Larsson BS. Interaction between chemicals and melanin. Pigment Cell Res 1993; 6: 127-133.
13. Wang Y, Casadevall A. Growth of Cryptococcus neoformans in presence of L-dopa decreases its susceptibility to amphotericin B. Antimicrob Agents Chemother 1994; 38: 2648-2650.
14. Nosanchuk JD, Rudolph J, Rosas AL, Casadevall A. Evidence that Cryptococcus neoformans is melanized in pigeon excreta: implications for pathogenesis. Infect Immun 1999; 67: 5477-5479.
15. Jahn B, Boukhallouk F, Lotz J et al. Interaction of human phagocytes with pigmentless Aspergillus conidia. Infect Immun 2000; 68: 3736-3739.
16. Dadachova E, Casadevall A. Host and microbial cells as targets for armed antibodies in the treatment of infectious diseases. Curr Opin Investig Drugs 2008; 9: 184-188.
17. Wang Y, Casadevall A. Susceptibility of melanized and non-melanized Cryptococcus neoformans to nitrogen-and oxygen-derived oxidants. Infect Immun 1994; 62: 3004-3007.
18. Bell AA, Wheeler MA. Biosysnthesis and functions of fungal melanins. Annu Rev Phytopathol 1986; 24: 411-451.
19. Jahn B, Koch A, Schmidt A et al. Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence. Infect Immun 1997; 65: 5110-5117.
20. Jahn B, Langfelder K, Schneider U, Schindel C, Brakhage AA. PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages. Cell Microbiol 2002; 4: 793-803.
21. Langfelder K, Jahn B, Gehringer H et al. Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence. Med Mi-crobiol Immunol 1998; 187: 79-89.
22. Goncalves RC, Lisboa HC, Pombeiro-Sponchiado SR. Characterization of melanin pigment produced by Aspergillus nidulans. World J Microbiol Biotechnol 2012; 28: 1467-1474.
23. Kumar CG, Mongolla P, Pombala S, Kamle A, Joseph J. Physic-ochemical characterization and antioxidant activity of melanin from a novel strain of Aspergillus bridgeri ICTF-201. Lett Appl Microbiol 2011; 53: 350-358.
24. Wargenau A, Fleissner A, Bolten CJ et al. On the origin of the electrostatic surface potential of Aspergillus niger spores in acidic environments. Res Microbiol 2011; 162: 1011-1017.
25. de Cassia R, Goncalves R, Pombeiro-Sponchiado SR. Antioxi-dant activity of the melanin pigment extracted from Aspergillus nidulans. Biol Pharm Bull 2005; 28: 1129-1131.
26. Sava VM, Galkin BN, Hong M-Y, Yang P-C, Huang GS. A novel melanin-like pigment derived from black tea leaves with immuno-stimulating activity Food Res Int 2001; 34: 337-343.
27. Gadd GM. Effects of media composition and light on colony differentiation and melanin synthesis in Microdochium bolleyi. Trans British Mycol Soc 1982; 78: 115-122.
28. Babitskaia VG, Shcherba VV, Filimonova TV, Grigorchuk EZ. Melanin pigments of the fungi Paecilomyces variotii and As-pergillus carbonarius. Prikl Biokhim Mikrobiol 2000; 36: 153-159.
29. Elliott ML. Effect of melanin biosynthesis inhibiting compounds on Gaeumannomyces species. Mycologia 1995; 87: 370-374.
30. Suryanarayanan TS, Ravishankar JP, Venkatesan G, Murali TS. Characterization of the melanin pigment of a cosmopolitan fungal endophyte. Mycol Res 2004; 108: 974-978.
31. Selvakumar P, Rajasekar S, Periasamy K, Raaman N. Isolation and characterization of melanin pigment from Pleurotus cys-tidiosus (Telomorph of Antromycopsis macrocarpa). World J Microbiol Biotechnol 2008; 24: 2125-2131.
32. Enochs WS, Nilges MJ, Swartz HM. A standardized test for the identification and characterization of melanins using electron paramagnetic resonance (EPR) spectroscopy. Pigment Cell Res 1993; 6: 91-99.
33. Senesi N, Miano TM, Martin JP. Elemental, functional infrared and free radical characterization of humic acid-type fungal polymers (melanins). Biol Fertil Soils 1987; 5: 120-125.
34. Eisenman HC, Casadevall A. Synthesis and assembly of fungal melanin. Appl Microbiol Biotechnol 2011; 93: 931-940.
35. de Hoog GS, Zalar P, van den Ende BG, Gunde-Cimerman N. Relation of halotolerance to human-pathogenicity in the fungal tree of life: an overview of ecology and evolution under stress. In: Gunde-Cimerman N, Oren A, Plemenitaš A (eds). Adaptation to Life at High Salt Concentrations in Archaea, Bacteria, and Eukarya, vol. 9. Dordrecht, the Netherlands: Springer, 2005: 373-395.
36. Wheeler MH, Abramczyk D, Puckhaber LS et al. New biosynthetic step in the melanin pathway of Wang-iella (Exophiala) dermatitidis: evidence for 2-acetyl-1, 3, 6, 8-tetrahydroxynaphthalene as a novel precursor. Eukaryot Cell 2008; 7: 1699-1711.
37. Romero-Martinez R, Wheeler M, Guerrero-Plata A, Rico G, Torres-Guerrero H. Biosynthesis and functions of melanin in Sporothrix schenckii. Infect Immun 2000; 68: 3696-3703.
38. Carzaniga R, Fiocco D, Bowyer P, O'Connell RJ. Localization of melanin in conidia of Alternaria alternata using phage display antibodies. Mol Plant Microbe Interact 2002; 15: 216-224.
39. San-Blas G, Guanipa O, Moreno B, Pekerar S, San-Blas F. Cla-dosporium carrionii and Hormoconis resinae (C. resinae): cell wall and melanin studies. Curr Microbiol 1996; 32: 11-16.
40. Cunha MM, Franzen AJ, Seabra SH et al. Melanin in Fonsecaea pedrosoi: a trap for oxidative radicals. BMC Microbiol 2010; 10: 80.
41. Youngchim S, Morris-Jones R, Hay RJ, Hamilton AJ. Production of melanin by Aspergillus fumigatus. J Med Microbiol 2004; 53: 175-181.
42. Youngchim S, Hay RJ, Hamilton AJ. Melanization of Penicillium marneffei in vitro and in vivo. Microbiol 2005; 151: 291-299.
43. Wang Y, Aisen P, Casadevall A. Cryptococcus neoformans melanin and virulence: mechanism of action. Infect Immun 1995; 63: 3131-3136.
44. Taborda CP, da Silva MB, Nosanchuk JD, Travassos LR. Melanin as a virulence factor of Paracoccidioides brasiliensis and other dimorphic pathogenic fungi: a mini review. Myco-pathologia 2008; 165: 331-339.
45. Nosanchuk JD, Gomez BL, Youngchim S et al. Histoplasma cap-sulatum synthesizes melanin-like pigments in vitro and during mammalian infection. Infect Immun 2002; 70: 5124-5131.
46. Nosanchuk JD, van Duin D, Mandal P et al. Blastomyces der-matitidis produces melanin in vitro and during infection. FEMS Microbiol Lett 2004; 239: 187-193.
47. Walker CA, Gomez BL, Mora-Montes HM et al. Melanin ex-ternalization in Candida albicans depends on cell wall chitin structures. Eukaryot Cell 2010; 9: 1329-1342.
48. Nosanchuk JD, Yu JJ, Hung CY, Casadevall A, Cole GT. Coccid-ioides posadasii produces melanin in vitro and during infection. Fungal Genet Biol 2007; 44: 517-520.