About the gut microbiome as a pharmacological target in atherosclerosis

European Journal of Pharmacology

Volumn 763, Issue , 2015, Pages 75-78

  Witjes, Julia J ^a   Van Raalte, Daniel H ^a,b   Nieuwdorp, Max ^a,b,c  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Bacterial translocation; Chronic inflammation; Insulin resistance; Intestinal microbiota; Probiotics; Trained immunity; Vaccination; Visceral adipose tissue

Indexed keywords

SHORT CHAIN FATTY ACID; TRIMETHYLAMINE OXIDE;

ABDOMINAL FAT; ARTICLE; ATHEROSCLEROSIS; BACTERIAL TRANSLOCATION; CHOLESTEROL METABOLISM; DISEASE ASSOCIATION; ENERGY EXPENDITURE; FECES MICROFLORA; FOOD INTAKE; GLUCONEOGENESIS; HUMAN; IMMUNE RESPONSE; INSULIN RESISTANCE; INTESTINE FLORA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SOFT TISSUE INFLAMMATION; TREATMENT INDICATION; VACCINATION; ANIMAL; COMPLICATION; DRUG EFFECTS; METABOLISM; MICROBIOLOGY;

ANIMALS; ATHEROSCLEROSIS; GASTROINTESTINAL MICROBIOME; HUMANS;

EID: 84941940185     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.06.023     Document Type: Article

References (51)

1. C.M. Apovian, and et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects Arterioscler. Thromb. Vasc. Biol. 28 9 2008 1654 1659
2. F. Bäckhed, and et al. The gut microbiota as an environmental factor that regulates fat storage Proc. Natl. Acad. Sci. USA 101 44 2004 15718 15723
3. F. Bäckhed, and et al. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice Proc. Natl. Acad. Sci. USA 104 3 2007 979 984
4. L. Belinova, and et al. Differential acute postprandial effects of processed meat and isocaloric vegan meals on the gastrointestinal hormone response in subjects suffering from type 2 diabetes and healthy controls: a randomized crossover study PLoS One 9 9 2014 e107561
5. B.J. Bennett, and et al. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation Cell Metab. 17 1 2013 49 60
6. J.P. Boyle, and et al. Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence Popul. Health Metr. 8 2010 29
7. R. Caesar, and et al. Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism J. Intern. Med. 268 4 2010 320 328
8. P.D. Cani, and et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia Diabetologia 50 11 2007 2374 2383
9. P.V. Chang, and et al. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition Proc. Natl. Acad. Sci. USA 111 6 2014 2247 2252
10. S.C. Cheng, and et al. mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity Science 345 6204 2014 1250684
11. A. Cotillard, and et al. Dietary intervention impact on gut microbial gene richness Nature 500 7464 2013 585 588
12. L.A. David, and et al. Diet rapidly and reproducibly alters the human gut microbiome Nature 505 7484 2014 559 563
13. F. De Vadder, and et al. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits Cell 156 1-2 2014 84 96
14. A. Everard, and et al. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status Nat. Commun. 5 2014 5648
15. Z. Gao, and et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice Diabetes 58 7 2009 1509 1517
16. J.K. Goodrich, and et al. Human genetics shape the gut microbiome Cell 159 4 2014 789 799
17. J.T. Grayston, and et al. Azithromycin for the secondary prevention of coronary events N. Engl. J. Med. 352 16 2005 1637 1645
18. J.C. Gregory, and et al. Transmission of atherosclerosis susceptibility with gut microbial transplantation J. Biol. Chem. 290 9 2015 5647 5660
19. P. Hossain, and et al. Obesity and diabetes in the developing world - a growing challenge N. Engl. J. Med. 356 3 2007 213 215
20. F.H. Karlsson, and et al. Gut metagenome in European women with normal, impaired and diabetic glucose control Nature 498 7452 2013 99 103
21. M.H. Kim, and et al. Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice Gastroenterology 145 2 2013 396 406
22. R.A. Koeth, and et al. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis Nat. Med. 19 5 2013 576 585
23. L.C. Kong, and et al. Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes Am. J. Clin. Nutr. 98 1 2013 16 24
24. E., Le Chatelier, and et al. Richness of human gut microbiome correlates with metabolic markers Nature 500 7464 2013 541 546
25. H.A. Lehr, and et al. Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet Circulation 104 8 2001 914 920
26. K.M. Maslowski, and et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43 Nature 461 7268 2009 1282 1286
27. S. Mueller, and et al. Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study Appl. Environ. Microbiol. 72 2 2006 1027 1033
28. E. Pouteau, and et al. Production rates and metabolism of short-chain fatty acids in the colon and whole body using stable isotopes Proc. Nutr. Soc. 62 1 2003 87 93
29. J. Qin, and et al. A metagenome-wide association study of gut microbiota in type 2 diabetes Nature 490 7418 2012 55 60
30. S. Saeed, and et al. Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity Science 345 6204 2014 1251086
31. Y. Sanz, and et al. Gut microbiota in obesity and metabolic disorders 2010 Proc. Nutr. Soc. 69 3 2010 434 441
32. J.D. Smith, and et al. Visceral adipose tissue indicates the severity of cardiometabolic risk in patients with and without type 2 diabetes: results from the INSPIRE ME IAA study J. Clin. Endocrinol. Metab. 97 5 2012 1517 1525
33. A.R. Spaulding, and et al. Immunity to Staphylococcus aureus secreted proteins protects rabbits from serious illnesses Vaccine 30 34 2012 5099 5109
34. K. Stronks, and et al. Unravelling the impact of ethnicity on health in Europe: the HELIUS study BMC Public Health 13 2013 402
35. G. Swaminathan, and et al. A role for microRNA-155 modulation in the effects of Toll-like receptor 3 stimulation in macrophages PLoS Pathog. 8 9 2012 e1002937
36. A. Schwiertz, and et al. Microbiota and SCFA in lean and overweight healthy subjects Obesity 18 1 2010 190 195
37. W.H.W. Tang, and et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk N. Engl. J. Med. 368 17 2013 1575 1584
38. W.H. Tang, and et al. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis J. Am. Coll. Cardiol. 64 18 2014 1908 1914
39. F. Tsai, and W.J. Coyle The microbiome and obesity: is obesity linked to our gut flora? Curr. Gastroenterol. Rep. 11 4 2009 307 313
40. H. Tilg, and et al. Obesity and the microbiota Gastroenterology 136 5 2009 1476 1483
41. H. Tilg Obesity, metabolic syndrome, and microbiota: multiple interactions J. Clin. Gastroenterol. 44 2010 S16 S18
42. V. Tremaroli, and F. Bäckhed Functional interactions between the gut microbiota and host metabolism Nature 489 7415 2012 242 249 10.1038/nature11552
43. P.J. Turnbaugh, and et al. An obesity-associated gut microbiome with increased capacity for energy harvest Nature 444 7122 2006 1027 1031
44. P.J. Turnbaugh, and et al. The human microbiome project Nature 449 7164 2007 804 810
45. A. Vrieze, and et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome Gastroenterology 143 4 2012 913 916
46. A. Vrieze, and et al. Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity J. Hepatol. 60 4 2014 824 831
47. Z. Wang, and et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease Nature 472 7341 2011 57 63
48. J.M. Wentworth, and et al. Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity Diabetes 59 7 2010 1648 1656
49. M. Westerterp, and et al. Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice Circulation 116 19 2007 2173 2181
50. D. Wang, and et al. Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10b Circ. Res. 111 8 2012 967 981
51. G.D. Wu, and et al. Linking long-term dietary patterns with gut microbial enterotypes Science 334 6052 2011 105 108