Genome-wide autozygosity is associated with lower general cognitive ability

Molecular Psychiatry

Volumn 21, Issue 6, 2016, Pages 837-843

  Howrigan, D P ^a,b   Simonson, M A ^c   Davies, G ^d   Harris, S E ^d   Tenesa, A ^d,e   Starr, J M ^d   Liewald, D C ^d   Deary, I J ^d   McRae, A ^f,g   Wright, M J ^f   Montgomery, G W ^f   Hansell, N ^f   Martin, N G ^f   Payton, A ^h   Horan, M ^h   Ollier, W E ^h   Abdellaoui, A ^i,j   Boomsma, D I ^i,j,k   DeRosse, P ^l,m,n   Knowles, E E M ^o   Glahn, D C ^o   Djurovic, S ^p,q   Melle, I ^p,q,r   Andreassen, O A ^p,q,r   Christoforou, A ^s,t   Steen, V M ^s,t   Hellard, S L ^s,t   Sundet, K ^p,r   Reinvang, I ^r   Espeseth, T ^q,r   Lundervold, A J ^s,u   Giegling, I ^v   Konte, B ^v   Hartmann, A M ^v   Rujescu, D ^v   Roussos, P ^w,x   Giakoumaki, S ^y   Burdick, K E ^w   Bitsios, P ^y,z   Donohoe, G ^aa   Corley, R P ^ab   Visscher, P M ^d,f,g   Pendleton, N ^h   Malhotra, A K ^l,m,n   Neale, B M ^a,b   Lencz, T ^l,m,n   Keller, M C ^ab   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^g UNIVERSITY OF QUEENSLAND   (Australia)

^h UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁱ VU UNIVERSITY AMSTERDAM   (Netherlands)

^j Neuroscience Campus Amsterdam ^*  (Netherlands)

^k UNIVERSITY OF AMSTERDAM   (Netherlands)

^l ZUCKER HILLSIDE HOSPITAL   (United States)

^m FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

ⁿ DONALD AND BARBARA ZUCKER SCHOOL OF MEDICINE AT HOFSTRA NORTHWELL   (United States)

^o YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^p KG Jebsen Centre   (Norway)

^q OSLO UNIVERSITY HOSPITAL   (Norway)

^r UNIVERSITY OF OSLO   (Norway)

^s UNIVERSITY OF BERGEN   (Norway)

^t HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^u STATOIL   (Norway)

^v MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^w MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^x VETERANS AFFAIRS MEDICAL CENTER   (United States)

^y UNIVERSITY OF CRETE   (Greece)

^z INSTITUTE OF COMPUTER SCIENCE   (Greece)

^aa NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^ab UNIVERSITY OF COLORADO   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANCESTRY GROUP; ARTICLE; AUTOZYGOSITY; COGNITION; EFFECT SIZE; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC PARAMETERS; GENOME; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGENY; SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; CAUCASIAN; CHROMOSOMAL MAPPING; FEMALE; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HOMOZYGOTE; HUMAN GENOME; INBREEDING DEPRESSION; MALE; PHYSIOLOGY; PROCEDURES;

ADULT; ALLELES; CHROMOSOME MAPPING; COGNITION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HOMOZYGOTE; HUMANS; INBREEDING DEPRESSION; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84941917087     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2015.120     Document Type: Article

References (44)

1. Carroll JB. Human Cognitive Abilities: A Survey of Factor-Analytic Studies. Cambridge University Press: New York, NY, 1993
2. Johnson W, Bouchard TJ, Krueger RF, McGue M, Gottesman II. Just one g: consistent results from three test batteries. Intelligence 2004; 32: 95-107
3. Johnson W, Nijenhuis Jt, Bouchard TJ. Still just 1g: Consistent results from five test batteries. Intelligence 2008; 36: 81-95
4. Batty GD, Deary IJ, Gottfredson LS. Premorbid (early life) IQ and later mortality risk: systematic review. Ann Epidemiol 2007; 17: 11
5. Deary IJ, Weiss A, Batty GD. Intelligence and personality as predictors of illness and death: How researchers in differential psychology and chronic disease epidemiology are collaborating to understand and address health inequalities. Psychol Sci Public Interest 2010; 11: 53-79
6. Gottfredson LS, Deary IJ. Intelligence predicts health and longevity, but why?. Curr Dir Psychol Sci 2004; 13: 1-4
7. Strenze T. Intelligence and socio-economic success: a meta-Analytic view of longitudinal research. Intelligence 2007; 35: 401-426
8. Erlenmeyer-Kimling L, Jarvik LF. Genetics and intelligence: a review. Science 1963; 142: 3
9. Bouchard TJ, McGue M. Familial studies of intelligence: a review. Science 1981; 212: 5
10. Deary IJ, Johnson W, Houlihan LM. Genetic foundations of human intelligence. Human Genetics. 2009; 126: 18
11. Deary IJ, Yang J, Davies G, Harris SE, Tenesa A, Liewald D, et al. Genetic contributions to stability and change in intelligence from childhood to old age. Nature 2012; 482: 212-215
12. Benyamin B, Pourcain BS, Davis OS, Davies G, Hansell NK, Brion M-JA, et al. Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Mol Psychiatry 2014; 19: 6
13. Davies G, Tenesa A, Payton A, Yang J, Harris SE, Liewald D, et al. Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry. 2011; 16: 996-1005, 11
14. Marioni RE, Davies G, Hayward C, Liewald D, Kerr SM, Campbell A, et al. Molecular genetic contributions to socioeconomic status and intelligence. Intelligence 2014; 44: 7
15. Afzal M. Consequences of consanguinity on cognitive behavior. Behav Genet 1988; 18: 12
16. Agrawal N, Sinha SN, Jensen AR. Effects of inbreeding on raven matrices. Behav Genet 1984; 14: 7
17. Badaruddoza, Afzal M. Inbreeding depression and intelligence quotient among north Indian children. Behav Genet 1993; 23: 343-347
18. Bashi J. Effects of inbreeding on cognitive performance. Nature 1977; 266: 3
19. Morton NE. Effect of inbreeding on IQ and mental retardation. Proc Natl Acad Sci USA 1978; 75: 3906-3908
20. Woodley MA. Inbreeding depression and IQ in a study of 72 countries. Intelligence 2009; 37: 268-276
21. Charlesworth D, Willis JH. The genetics of inbreeding depression. Nat Rev Genet 2009; 10: 783-796
22. Mukai T, Cardellino RA, Watanabe TK, Crow JF. The genetic variance for viability and its components in a local population of Drosophila melanogaster. Genetics 1974; 78: 1195-1208
23. Houle D, Hoffmaster DK, Assimacopoulos S, Charlesworth B. The genomic mutation rate for fitness in Drosophila. Nature 1992; 359: 58-60
24. McQuillan R, Leutenegger A-L, Abdel-Rahman R, Franklin CS, Pericic M, Barac-Lauc L, et al. Runs of homozygosity in European populations. Am J Hum Genet 2008; 83: 359-372
25. Nothnagel M, Lu TT, Kayser M, Krawczak M. Genomic and geographic distribution of SNP-defined runs of homozygosity in Europeans. Hum Mol Genet 2010; 19: 2927-2935
26. Kirin M, McQuillan R, Franklin CS, Campbell H, McKeigue PM, Wilson JF. Genomic Runs of Homozygosity Record Population History and Consanguinity. PLoS One 2010; 5: e13996
27. Carothers AD, Rudan I, Kolcic I, Polasek O, Hayward C, Wright AF, et al. Estimating human inbreeding coefficients: comparison of genealogical and marker heterozygosity approaches. Ann Hum Genet 2006; 70: 11
28. Keller MC, Visscher PM, Goddard ME. Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data. Genetics 2011; 189: 13
29. Ku CS, Naidoo N, Teo SM, Pawitan Y. Regions of homozygosity and their impact on complex diseases and traits. Hum Genet 2011; 129: 15
30. Power RA, Nagoshi C, DeFries JC, Consortium WTCC, Plomin R. Genome-wide estimates of inbreeding in unrelated individuals and their association with cognitive ability. Eur J Hum Genet 2014; 22: 386-390
31. Keller MC, Simonson MA, Ripke S, Neale BM, Gejman PV, Howrigan DP, et al. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. PLoS Genet 2012; 8: e1002656
32. McQuillan R, Eklund N, Pirastu N, Kuningas M, McEvoy BP, Esko T, et al. Evidence of inbreeding depression on human height. PLoS Genet 2012; 8: e1002655
33. Verweij KJH, Yang J, Lahti J, Veijola J, Hintsanen M, Pulkki-Raback L, et al. Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding. Evolution 2012; 66: 3238-3251
34. Lencz T, Knowles E, Davies G, Guha S, Liewald DC, Starr JM, et al. Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT). Mol Psychiatry 2014; 19: 168-174
35. International HapMap C, Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, et al. A second generation human haplotype map of over 3.1 million SNPs. Nature 2007; 449: 851-861
36. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575
37. Howrigan DP, Simonson MA, Keller MC. Detecting autozygosity through runs of homozygosity: a comparison of three autozygosity detection algorithms. BMC Genomics 2011; 12: 460
38. Laurie CC, Doheny KF, Mirel DB, Pugh EW, Bierut LJ, Bhangale T, et al. Quality control and quality assurance in genotypic data for genome-wide association studies. Genet Epidemiol 2010; 34: 12
39. Alper CA, Larsen CE, Dubey DP, Awdeh ZL, Fici DA, Yunis EJ. The haplotype structure of the human major histocompatibility complex. Hum Immunol 2006; 67: 73-84
40. Bersaglieri T, Sabeti P, Patterson N, Vanderploeg T, Schaffner S, Drake J, et al. Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet 2004; 74: 1111-1120
41. Valero R, Marfany G, Gonzalez-Angulo O, Gonzalez-Gonzalez G, Puelles L, Gonzalez-Duarte R. USP25, a Novel Gene Encoding a Deubiqiutinating Enzyme, is Located in the Gene-Poor Region of 21q11.2. Genomics 1999; 62: 395-405
42. Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, et al. Directional dominance on stature and cognitiion in diverse human populations. Nature 2015; 523: 459-462
43. Abdellaoui A, Hottenga J-J, Xiao X, Scheet P, Ehli EA, Davies GE, et al. Association between autozygosity and major depression: stratification due to religious assortment. Behav Genet 2013; 43: 13
44. Abdellaoui A, Hottenga J-J, Willemsen G, Bartels M, Tv Beijsterveldt, Ehli EA, et al. Educational attainment influences genetic variation through migration and assortative mating. PLoS One 2014; 10: e0118935