Directional dominance on stature and cognition in diverse human populations

Nature

Volumn 523, Issue 7561, 2015, Pages 459-462

  Joshi, Peter K ^a   Esko, Tonu ^b,c,d,e   Mattsson, Hannele ^f,g   Eklund, Niina ^f   Gandin, Ilaria ^h   Nutile, Teresa ⁱ   Jackson, Anne U ^j   Schurmann, Claudia ^k   Smith, Albert V ^l,m   Zhang, Weihua ^n,o   Okada, Yukinori ^p,q   Stančáková, Alena ^r   Faul, Jessica D ^j   Zhao, Wei ^j   Bartz, Traci M ^s   Concas, Maria Pina ^t   Franceschini, Nora ^u   Enroth, Stefan ^v   Vitart, Veronique ^w   Trompet, Stella ^x   Guo, Xiuqing ^y,z   Chasman, Daniel I ^e   O'Connel, Jeffrey R ^aa   Corre, Tanguy ^ab,ac   Nongmaithem, Suraj S ^ad   Chen, Yuning ^ae   Mangino, Massimo ^af,ag   Ruggiero, Daniela ⁱ   Traglia, Michela ^ah   Farmaki, Aliki Eleni ^ai   Kacprowski, Tim ^aj   Bjonnes, Andrew ^ak   Van Der Spek, Ashley ^al   Wu, Ying ^am   Giri, Anil K ^an   Yanek, Lisa R ^ao   Wang, Lihua ^ap   Hofer, Edith ^aq   Rietveld, Cornelius A ^ar   McLeod, Olga ^as   Cornelis, Marilyn C ^at,au   Pattaro, Cristian ^av,by   Verweij, Niek ^aw   Baumbach, Clemens ^ax   Abdellaoui, Abdel ^ay   Warren, Helen R ^az,ba   Vuckovic, Dragana ^h   Mei, Hao ^bb   Bouchard, Claude ^bc   Perry, John R B ^bd   Cappellani, Stefania ^be   Mirza, Saira S ^al   Benton, Miles C ^bf   Broeckel, Ulrich ^bg   Medland, Sarah E ^bh   Lind, Penelope A ^bh   Malerba, Giovanni ^bi   Drong, Alexander ^bj   Yengo, Loic ^bk   Bielak, Lawrence F ^j   Zhi, Degui ^bl   Van Der Most, Peter J ^aw   Shriner, Daniel ^bm   Mägi, Reedik ^b   Hemani, Gibran ^bn   Karaderi, Tugce ^bj   Wang, Zhaoming ^bo,bp   Liu, Tian ^bq,br   Demuth, Ilja ^bs   Zhao, Jing Hua ^bd   Meng, Weihua ^bt   Lataniotis, Lazaros ^az   Van Der Laan, Sander W ^bu   Bradfield, Jonathan P ^bv   Wood, Andrew R ^bw   Bonnefond, Amelie ^bk   Ahluwalia, Tarunveer S ^bx,bz,fg   Hall, Leanne M ^ca   Salvi, Erika ^cb   Yazar, Seyhan ^cc   Carstensen, Lisbeth ^cd   De Haan, Hugoline G ^x   Abney, Mark ^ce   Afzal, Uzma ^n,o   Allison, Matthew A ^cf   Amin, Najaf ^al   Asselbergs, Folkert W ^bu,cg,ch   Bakker, Stephan J L ^aw   Barr, R Graham ^ci   Baumeister, Sebastian E ^aj   Benjamin, Daniel J ^cj,ck   Bergmann, Sven ^ab,ac   Boerwinkle, Eric ^cl   Bottinger, Erwin P ^k   Campbell, Archie ^cm   Chakravarti, Aravinda ^ao   Chan, Yingleong ^c,d,e   Chanock, Stephen J ^bo   Chen, Constance ^au   Chen, Y D Ida ^y,z   Collins, Francis S ^bm   Connell, John ^cn   Correa, Adolfo ^bb   Cupples, L Adrienne ^ae,co   Smith, George Davey ^bn   Davies, Gail ^cm   Dörr, Marcus ^aj   Ehret, Georg ^ao,cp   Ellis, Stephen B ^k   Feenstra, Bjarke ^cd   Feitosa, Mary F ^ap   Ford, Ian ^cq   Fox, Caroline S ^e,co   Frayling, Timothy M ^bw   Friedrich, Nele ^aj   Geller, Frank ^cd   Scotland, Generation ^cm   Gillham Nasenya, Irina ^af   Gottesman, Omri ^k   Graff, Misa ^u   Grodstein, Francine ^au   Gu, Charles ^cr   Haley, Chris ^w,cs   Hammond, Christopher J ^af   Harris, Sarah E ^cm   Harris, Tamara B ^ct   Hastie, Nicholas D ^w   Heard Costa, Nancy L ^co,cu   Heikkilä, Kauko ^g   Hocking, Lynne J ^cv   Homuth, Georg ^aj   Hottenga, Jouke Jan ^ay   Huang, Jinyan ^cw   Huffman, Jennifer E ^w   Hysi, Pirro G ^af   Ikram, M Arfan ^al   Ingelsson, Erik ^bj,cx   Joensuu, Anni ^f,g   Johansson, Åsa ^v,cx   Jousilahti, Pekka ^f   Jukema, J Wouter ^x   Kähönen, Mika ^cy   Kamatani, Yoichiro ^q   Kanoni, Stavroula ^az   Kerr, Shona M ^w   Khan, Nazir M ^an   Koellinger, Philipp ^ar   Koistinen, Heikki A ^f,cz,da   Kooner, Manraj K ^o   Kubo, Michiaki ^db   Kuusisto, Johanna ^dc   Lahti, Jari ^g   Launer, Lenore J ^ct   Lea, Rodney A ^bf   Lehne, Benjamin ⁿ   Lehtimäki, Terho ^cy   Liewald, David C M ^cm   Lind, Lars ^dd   Loh, Marie ^n,fh   Lokki, Marja Liisa ^de   London, Stephanie J ^df   Loomis, Stephanie J ^dg   Loukola, Anu ^g   Lu, Yingchang ^k   Lumley, Thomas ^dh   Lundqvist, Annamari ^f   Männistö, Satu ^f   Marques Vidal, Pedro ^di   Masciullo, Corrado ^ah   Matchan, Angela ^dj   Mathias, Rasika A ^ao   Matsuda, Koichi ^dk   Meigs, James B ^ak   Meisinger, Christa ^ax   Meitinger, Thomas ^ax,dl   Menni, Cristina ^af   Mentch, Frank D ^bv   Mihailov, Evelin ^b   Milani, Lili ^b   Montasser, May E ^aa   Montgomery, Grant W ^bh   Morrison, Alanna ^cl   Myers, Richard H ^cu   Nadukuru, Rajiv ^k   Navarro, Pau ^w   Nalis, Mari ^b   Nieminen, Markku S ^cz   Nolte, Ilja M ^aw   O'Connor, George T ^co,cu   Ogunniyi, Adesola ^dm   Padmanabhan, Sandosh ^cq   Palmas, Walter R ^ci   Pankow, James S ^dn   Patarcic, Inga ^do   Pavani, Francesca ^av,by   Peyser, Patricia A ^j   Pietilainen, Kirsi ^g,cz   Poulter, Neil ⁿ   Prokopenko, Inga ⁿ   Ralhan, Sarju ^dp   Redmond, Paul ^cm   Rich, Stephen S ^dq   Rissanen, Harri ^f   Robino, Antonietta ^be   Rose, Lynda M ^e   Rose, Richard ^dr   Sala, Cinzia ^ah   Salako, Babatunde ^dm   Salomaa, Veikko ^f   Sarin, Antti Pekka ^f,g   Saxena, Richa ^ak   Schmidt, Helena ^aq   Scott, Laura J ^j   Scott, William R ^n,o   Sennblad, Bengt ^as,ds   Seshadri, Sudha ^co,cu   Sever, Peter ⁿ   Shrestha, Smeeta ^ad   Smith, Blair H ^bt   Smith, Jennifer A ^j   Soranzo, Nicole ^dj   Sotoodehnia, Nona ^s   Southam, Lorraine ^bj,dj   Stanton, Alice V ^dt   Stathopoulou, Maria G ^du   Strauch, Konstantin ^ax,dv   Strawbridge, Rona J ^as   Suderman, Matthew J ^bn   Tandon, Nikhil ^dw   Tang, Sian Tsun ^dx   Taylor, Kent D ^y,z   Tayo, Bamidele O ^dy   Töglhofer, Anna Maria ^aq   Tomaszewski, Maciej ^ca,dz   Tšernikova, Natalia ^b,ea   Tuomilehto, Jaakko ^f,eb,ec   Uitterlinden, Andre G ^al   Vaidya, Dhananjay ^ao,ed   Van Hylckama Vlieg, Astrid ^x   Van Setten, Jessica ^bu   Vasankari, Tuula ^ee   Vedantam, Sailaja ^c,d,e   Vlachopoulou, Efthymia ^de   Vozzi, Diego ^be   Vuoksimaa, Eero ^g   Waldenberger, Melanie ^ax   Ware, Erin B ^j   Wentworth Shields, William ^ce   Whitfield, John B ^bh   Wild, Sarah ^a   Willemsen, Gonneke ^ay   Yajnik, Chittaranjan S ^ef   Yao, Jie ^y   Zaza, Gianluigi ^eg   Zhu, Xiaofeng ^eh   Salem, Rany M ^c,d,e   Melbye, Mads ^cd,ei   Bisgaard, Hans ^bx   Samani, Nilesh J ^ca,dz   Cusi, Daniele ^cb   Mackey, David A ^cc   Cooper, Richard S ^dy   Froguel, Philippe ^n,bk   Pasterkamp, Gerard ^bu   Grant, Struan F A ^bv,ej   Hakonarson, Hakon ^bv,ej   Ferrucci, Luigi ^ek   Scott, Robert A ^bd   Morris, Andrew D ^a   Palmer, Colin N A ^bt   Dedoussis, George ^ai   Deloukas, Panos ^az,ec   Bertram, Lars ^n,br,by   Lindenberger, Ulman ^bq   Berndt, Sonja I ^bo   Lindgren, Cecilia M ^d,bj   Timpson, Nicholas J ^bn   Tönjes, Anke ^el   Munroe, Patricia B ^az,ba   Sørensen, Thorkild I A ^bn,bz,em   Rotimi, Charles N ^bm   Arnett, Donna K ^bl   Oldehinkel, Albertine J ^aw   Kardia, Sharon L R ^j   Balkau, Beverley ^en   Gambaro, Giovanni ^eo   Morris, Andrew P ^b,bj,ep   Eriksson, Johan G ^f,g,cz,eq   Wright, Margie J ^bh   Martin, Nicholas G ^bh   Hunt, Steven C ^er   Starr, John M ^cm   Deary, Ian J ^cm   Griffiths, Lyn R ^bf   Tiemeier, Henning ^al   Pirastu, Nicola ^h,be   Kaprio, Jaakko ^f,g   Wareham, Nicholas J ^bd   Pérusse, Louis ^es   Wilson, James G ^bb   Girotto, Giorgia ^h   Caulfield, Mark J ^az,ba   Raitakari, Olli ^et,eu   Boomsma, Dorret I ^ay   Gieger, Christian ^ax   Van Der Harst, Pim ^aw,cg   Hicks, Andrew A ^av,by   Kraft, Peter ^au   Sinisalo, Juha ^cz   Knekt, Paul ^f   Johannesson, Magnus ^ev   Magnusson, Patrik K E ^ds   Hamsten, Anders ^as   Schmidt, Reinhold ^aq   Borecki, Ingrid B ^ap   Vartiainen, Erkki ^f   Becker, Diane M ^ao,ed   Bharadwaj, Dwaipayan ^an,fi   Mohlke, Karen L ^am   Boehnke, Michael ^j   Van Duijn, Cornelia M ^al   Sanghera, Dharambir K ^ew,ex   Teumer, Alexander ^aj   Zeggini, Eleftheria ^dj   Metspalu, Andres ^b,ea   Gasparini, Paolo ^be,ey   Ulivi, Sheila ^be   Ober, Carole ^ce   Toniolo, Daniela ^ah   Rudan, Igor ^a   Porteous, David J ^cm   Ciullo, Marina ⁱ   Spector, Tim D ^af   Hayward, Caroline ^w   Dupuis, Josée ^ae,co   Loos, Ruth J F ^k   Wright, Alan F ^w   Chandak, Giriraj R ^ad,ez   Vollenweider, Peter ^di   Shuldiner, Alan R ^aa,fa   Ridker, Paul M ^e   Rotter, Jerome I ^y,z   Sattar, Naveed ^fb   Gyllensten, Ulf ^v   North, Kari E ^u,fc   Pirastu, Mario ^t   Psaty, Bruce M ^s,fd   Weir, David R ^j   Laakso, Markku ^dc   Gudnason, Vilmundur ^l,m   Takahashi, Atsushi ^q   Chambers, John C ^n,o,fe   Kooner, Jaspal S ^o,dx,fe   Strachan, David P ^ff   Campbell, Harry ^a   Hirschhorn, Joel N ^c,d,e   Perola, Markus ^b,f   Polašek, Ozren ^a,do   Wilson, James F ^a,w   more..

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF TARTU   (Estonia)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^g UNIVERSITY OF HELSINKI   (Finland)

^h UNIVERSITY OF TRIESTE   (Italy)

ⁱ INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^j UNIVERSITY OF MICHIGAN   (United States)

^k MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^l ICELANDIC HEART ASSOCIATION   (Iceland)

^m UNIVERSITY OF ICELAND   (Iceland)

ⁿ IMPERIAL COLLEGE LONDON   (United Kingdom)

^o EALING HOSPITAL NHS TRUST   (United Kingdom)

^p TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^q RIKEN Center for Integrative Medical Sciences   (Japan)

^r UNIVERSITY OF EASTERN FINLAND   (Finland)

^s UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^t CNR   (Italy)

^u IL   (United States)

^v UPPSALA UNIVERSITY   (Sweden)

^w UNIVERSITY OF EDINBURGH   (United Kingdom)

^x LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^y LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^z UNIVERSITY OF CALIFORNIA   (United States)

^aa UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^ab UNIVERSITY OF LAUSANNE   (Switzerland)

^ac SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^ad CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^ae BOSTON UNIVERSITY   (United States)

^af KING'S COLLEGE LONDON   (United Kingdom)

^ag GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^ah SAN RAFFAELE HOSPITAL   (Italy)

^ai HAROKOPIO UNIVERSITY   (Greece)

^aj UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^ak MASSACHUSETTS GENERAL HOSPITAL   (United States)

^al ERASMUS MEDICAL CENTER   (Netherlands)

^am UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^an CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^ao JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ap WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^aq MEDICAL UNIVERSITY OF GRAZ   (Austria)

^ar ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^as KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^at BRIGHAM AND WOMEN S HOSPITAL   (United States)

^au HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^av University of Lubeck   (Italy)

^aw UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^ax INSTITUTE OF EPIDEMIOLOGY   (Germany)

^ay VU UNIVERSITY AMSTERDAM   (Netherlands)

^az QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^ba QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^bb UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^bc PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^bd UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^be INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^bf QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^bg MEDICAL COLLEGE OF WISCONSIN   (United States)

^bh QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^bi UNIVERSITY OF VERONA   (Italy)

^bj UNIVERSITY OF OXFORD   (United Kingdom)

^bk Institut Pasteur de Lille   (France)

^bl UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^bm NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^bn UNIVERSITY OF BRISTOL   (United Kingdom)

^bo NATIONAL CANCER INSTITUTE   (United States)

^bp SAIC FREDERICK INC   (United States)

^bq MAX PLANCK INSTITUTE FOR HUMAN DEVELOPMENT   (Germany)

^br MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^bs CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^bt UNIVERSITY OF DUNDEE   (United Kingdom)

^bu UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^bv CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^bw UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^bx UNIVERSITY OF COPENHAGEN   (Denmark)

^by UNIVERSITY OF LÜBECK   (Germany)

^bz UNIVERSITY OF COPENHAGEN   (Denmark)

^ca UNIVERSITY OF LEICESTER   (United Kingdom)

^cb UNIVERSITY OF MILAN   (Italy)

^cc UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^cd STATENS SERUM INSTITUT   (Denmark)

^ce UNIVERSITY OF CHICAGO   (United States)

^cf UNIVERSITY OF CALIFORNIA   (United States)

^cg ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^ch UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ci Och Spine at New York Presbyterian Hospitals   (United States)

^cj Department of Obstetrics Gynecology   (United States)

^ck UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^cl UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^cm UNIVERSITY OF EDINBURGH   (United Kingdom)

^cn UNIVERSITY OF DUNDEE   (United Kingdom)

^co FRAMINGHAM HEART STUDY   (United States)

^cp GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^cq UNIVERSITY OF GLASGOW   (United Kingdom)

^cr WASHINGTON UNIVERSITY   (United States)

^cs UNIVERSITY OF EDINBURGH   (United Kingdom)

^ct NATIONAL INSTITUTES OF HEALTH   (United States)

^cu BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cv UNIVERSITY OF ABERDEEN   (United Kingdom)

^cw SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^cx UPPSALA UNIVERSITY   (Sweden)

^cy TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^cz HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^da MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^db RCfIMS   (Japan)

^dc KUOPIO UNIVERSITY HOSPITAL   (Finland)

^dd UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^de UNIVERSITY OF HELSINKI   (Finland)

^df NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^dg MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^dh UNIVERSITY OF AUCKLAND   (New Zealand)

^di LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^dj WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^dk UNIVERSITY OF TOKYO   (Japan)

^dl TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^dm UNIVERSITY OF IBADAN   (Nigeria)

^dn UNIVERSITY OF MINNESOTA   (United States)

^do UNIVERSITY OF SPLIT   (Croatia)

^dp Hero DMC Heart Institute   (India)

^dq UNIVERSITY OF VIRGINIA   (United States)

^dr INDIANA UNIVERSITY   (United States)

^ds KAROLINSKA INSTITUTE   (Sweden)

^dt ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^du UNIVERSITÉ DE LORRAINE   (France)

^dv UNIVERSITY OF MUNICH   (Germany)

^dw ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^dx NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^dy LOYOLA UNIVERSITY CHICAGO   (United States)

^dz UNIVERSITY OF LEICESTER   (United Kingdom)

^ea UNIVERSITY OF TARTU   (Estonia)

^eb DANUBE UNIVERSITY KREMS   (Austria)

^ec KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^ed JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^ee Finnish Lung Health Association   (Finland)

^ef KEM HOSPITAL   (India)

^eg UNIVERSITY OF VERONA   (Italy)

^eh CASE WESTERN RESERVE UNIVERSITY   (United States)

^ei STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ej UNIVERSITY OF PENNSYLVANIA   (United States)

^ek NATIONAL INSTITUTE ON AGING   (United States)

^el UNIVERSITY OF LEIPZIG   (Germany)

^em The Capital Region   (Denmark)

^en CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^eo CATHOLIC UNIVERSITY   (Italy)

^ep UNIVERSITY OF LIVERPOOL   (United Kingdom)

^eq VAASA CENTRAL HOSPITAL   (Finland)

^er UNIVERSITY OF UTAH   (United States)

^es UNIVERSITÉ LAVAL   (Canada)

^et TURKU UNIVERSITY HOSPITAL   (Finland)

^eu UNIVERSITY OF TURKU   (Finland)

^ev STOCKHOLM SCHOOL OF ECONOMICS   (Sweden)

^ew UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^ex UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^ey SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

^ez GENOME INSTITUTE OF SINGAPORE   (Singapore)

^fa BALTIMORE VA MEDICAL CENTER   (United States)

^fb UNIVERSITY OF GLASGOW   (United Kingdom)

^fc UNIVERSITY OF NORTH CAROLINA   (United States)

^fd CENTER FOR HEALTH STUDIES   (United States)

^fe IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^ff ST GEORGE S HOSPITAL   (United Kingdom)

^fg STENO DIABETES CENTER   (Denmark)

^fh AGENCY FOR SCIENCE   (Singapore)

^fi JAWAHARLAL NEHRU UNIVERSITY   (India)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

DOMINANCE; HUMAN GEOGRAPHY; SPATIAL COGNITION;

ARTICLE; ASSORTATIVE MATING; BLOOD PRESSURE; BODY HEIGHT; BODY MASS; CARDIOVASCULAR RISK; COHORT ANALYSIS; EDUCATIONAL STATUS; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENETIC ASSOCIATION; GENETIC SIMILARITY; GENOTYPE; HEREDITY; HOMOZYGOSITY; HUMAN; LUNG FUNCTION; LUNG VOLUME; MALE; POPULATION GENETIC STRUCTURE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SOCIAL COGNITION; SOCIAL DOMINANCE; STATISTICAL SIGNIFICANCE; COGNITION; EVOLUTION; GENETICS; HOMOZYGOTE; HUMAN GENOME; META ANALYSIS; PHENOTYPE;

BIOLOGICAL EVOLUTION; BLOOD PRESSURE; BODY HEIGHT; CHOLESTEROL, LDL; COGNITION; COHORT STUDIES; EDUCATIONAL STATUS; FEMALE; FORCED EXPIRATORY VOLUME; GENOME, HUMAN; HOMOZYGOTE; HUMANS; LUNG VOLUME MEASUREMENTS; MALE; PHENOTYPE;

EID: 84937889764     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14618     Document Type: Article

References (44)

1. Garrod, A. The incidence of alkaptonuria: a study of chemical individuality. Lancet 160, 1616-1620 (1902).
2. Darwin, C. The Variation of Animals and Plants Under Domestication (Appleton, 1868).
3. McQuillan, R. et al. Runs of homozygosity in European populations. Am. J. Hum. Genet. 83, 359-372 (2008).
4. McQuillan, R. et al. Evidence of inbreeding depression on human height. PLoS Genet. 8, e1002655 (2012).
5. Rudan, I. et al. Inbreeding and the genetic complexity of human hypertension. Genetics 163, 1011-1021 (2003).
6. Campbell, H. et al. Effects of genome-wide heterozygosity on a range of biomedically relevant human quantitative traits. Hum. Mol. Genet. 16, 233-241 (2007).
7. Charlesworth, D. & Willis, J. H. The genetics of inbreeding depression. Nature Rev. Genet. 10, 783-796 (2009).
8. Wright, S. Evolution and the Genetics of Populations, Vol. 3: Experimental Results and Evolutionary Deductions (University of Chicago Press, 1977).
9. Wright, S. Coefficients of inbreeding and relationships. Am. Nat. 56, 330-339 (1922).
10. Broman, K. W. & Weber, J. L. Long homozygous chromosomal segments in reference families from the Centre d'Étude du Polymorphisme Humain. Am. J. Hum. Genet. 65, 1493-1500 (1999).
11. Gibson, J., Morton, N. E. & Collins, A. Extended tracts of homozygosity in outbred human populations. Hum. Mol. Genet. 15, 789-795 (2006).
12. Kirin, M. et al. Genomic runs of homozygosity record population history and consanguinity. PLoS ONE 5, e13996 (2010).
13. Keller, M. C., Visscher, P. M. & Goddard, M. E. Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data. Genetics 189, 237-249 (2011).
14. Pemberton, T. J. & Rosenberg, N. A. Population-genetic influences on genomic estimates of the inbreeding coefficient: a global perspective. Hum. Hered. 77, 37-48 (2014).
15. Abdellaoui, A. et al. Educational attainment influences levels of homozygosity through migration and assortative mating. PLoS ONE 10, e0118935 (2015).
16. Neel, J. V. et al. The effects of parental consanguinity and inbreeding in Hirado, Japan. II. Physical development, tapping rate, blood pressure, intelligence quotient, and school performance. Am. J. Hum. Genet. 22, 263-286 (1970).
17. Marioni, R. E. et al. Common genetic variants explain the majority of the correlation between height and intelligence: the generation Scotland study. Behav. Genet. 44, 91-96 (2014).
18. Wood, A. R. et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genet. 46, 1173-1186 (2014).
19. Deary, I. J. et al. Genetic contributions to stability and change in intelligence from childhood to old age. Nature 482, 212-215 (2012).
20. Morton, N. E. Effect of inbreeding on IQandmental retardation. Proc. Natl Acad. Sci. USA 75, 3906-3908 (1978).
21. Najmabadi, H. et al. Deep sequencing reveals 50 novel genes for recessive cognitive disorders. Nature 478, 57-63 (2011).
22. Nalls, M. A. et al. Measures of autozygosity in decline: globalization, urbanization, and its implications for medical genetics. PLoS Genet. 5, e1000415 (2009).
23. Flynn, J. R. Massive IQ gains in 14 nations: what IQ tests really measure. Psychol. Bull. 101, 171-191 (1987).
24. Galton, F. Natural inheritance (MacMillan, 1889).
25. Hoffman, J. I. et al. High-throughput sequencing reveals inbreeding depression in a natural population. Proc. Natl Acad. Sci. USA 111, 3775-3780 (2014).
26. Wright, A., Charlesworth, B., Rudan, I., Carothers, A. & Campbell, H. A polygenic basis for late-onset disease. Trends Genet. 19, 97-106 (2003).
27. Weiss, L. A., Pan, L., Abney, M. & Ober, C. The sex-specific genetic architecture of quantitative traits in humans. Nature Genet. 38, 218-222 (2006).
28. Powell, J. E. et al. Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data. PLoS Genet. 9, e1003502 (2013).
29. Keller, M. C. et al. Runs of homozygosity implicate autozygosity as a schizophrenia risk factor. PLoS Genet. 8, e1002656 (2012).
30. Darwin, C. The Effects of Crossing and Self Fertilization in the Vegetable Kingdom (John Murray, 1876).
31. Purcell, S. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
32. Aulchenko, Y. S., Ripke, S., Isaacs, A. & van Duijn, C. M. GenABEL: an R library for genome-wide association analysis. Bioinformatics 23, 1294-1296 (2007).
33. Ronnegard, L., Shen, X. & Alam, M. hglm: a package for fitting hierarchical generalized linear models. R Journal 2, 20-28 (2010).
34. Lango Allen, H. et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838 (2010).
35. Ehret, G. B. et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 478, 103-109 (2011).
36. Scott, R. A. et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genet. 44, 991-1005 (2012).
37. Willer, C. J. et al. Discovery and refinement of loci associated with lipid levels. Nature Genet. 45, 1274-1283 (2013).
38. Soler Artigas, M. et al. Genome-wideassociationand large-scale followupidentifies 16 new loci influencing lung function. Nature Genet. 43, 1082-1090 (2011).
39. Rietveld, C. A. et al. GWAS of 126,559 individuals identified genetic variants associated with educational attainment. Science 340, 1467-1471 (2013).
40. Stefansson, H. et al. CNVs conferring risk of autism or schizophrenia affect cognition in controls. Nature 505, 361-366 (2014).
41. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56-65 (2012).
42. Aulchenko, Y. S., de Koning, D. J. & Haley, C. Genomewide rapid association using mixed model and regression: a fast and simple method for genome-wide pedigree-based quantitative trait loci association analysis. Genetics 177, 577-585 (2007).
43. Marioni, R. E. et al. Molecular genetic contributions to socioeconomic status and intelligence. Intelligence 44, 26-32 (2014).
44. Hedges, L. V. & Olkin, I. Statistical Methods for Meta-Analysis (Academic Press, New York, 1985).