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Volumn 93, Issue 8, 2015, Pages 753-764

MiR-21 controls in situ expansion of CCR6 + regulatory T cells through PTEN/AKT pathway in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD3 ANTIBODY; GAMMA INTERFERON; MICRORNA 21; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; STAT5 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; BIOLOGICAL MARKER; CHEMOKINE RECEPTOR CCR6; MICRORNA; MIRN21 MICRORNA, HUMAN;

EID: 84941878945     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2015.37     Document Type: Article
Times cited : (31)

References (40)
  • 1
    • 84875685651 scopus 로고    scopus 로고
    • Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses
    • Fukuyama Y, Tokuhara D, Sekine S, Aso K, Kataoka K, Davydova J et al. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS ONE 2013; 8: e60453.
    • (2013) PLoS ONE , vol.8 , pp. e60453
    • Fukuyama, Y.1    Tokuhara, D.2    Sekine, S.3    Aso, K.4    Kataoka, K.5    Davydova, J.6
  • 2
    • 84893650001 scopus 로고    scopus 로고
    • Chemokine receptor CCR6-dependent accumulation of T cells in injured liver restricts hepatic inflammation and fibrosis
    • Hammerich L, Bangen JM, Govaere O, Zimmermann HW, Gassler N, Huss S et al. Chemokine receptor CCR6-dependent accumulation of T cells in injured liver restricts hepatic inflammation and fibrosis. Hepatology 2014; 59: 630-642.
    • (2014) Hepatology , vol.59 , pp. 630-642
    • Hammerich, L.1    Bangen, J.M.2    Govaere, O.3    Zimmermann, H.W.4    Gassler, N.5    Huss, S.6
  • 3
    • 84906098694 scopus 로고    scopus 로고
    • Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors
    • Mercer F, Khaitan A, Kozhaya L, Aberg JA, Unutmaz D. Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors. J Immunol 2014; 193: 1047-1054.
    • (2014) J Immunol , vol.193 , pp. 1047-1054
    • Mercer, F.1    Khaitan, A.2    Kozhaya, L.3    Aberg, J.A.4    Unutmaz, D.5
  • 4
    • 78649826858 scopus 로고    scopus 로고
    • CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype
    • Kitamura K, Farber JM, Kelsall BL. CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype. J Immunol 2010; 185: 3295-3304.
    • (2010) J Immunol , vol.185 , pp. 3295-3304
    • Kitamura, K.1    Farber, J.M.2    Kelsall, B.L.3
  • 5
    • 15944425718 scopus 로고    scopus 로고
    • CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T cell subset
    • Kleinewietfeld M, Puentes F, Borsellino G, Battistini L, Rotzschke O, Falk K. CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T cell subset. Blood 2005; 105: 2877-2886.
    • (2005) Blood , vol.105 , pp. 2877-2886
    • Kleinewietfeld, M.1    Puentes, F.2    Borsellino, G.3    Battistini, L.4    Rotzschke, O.5    Falk, K.6
  • 6
    • 54049094815 scopus 로고    scopus 로고
    • Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha
    • Lamprecht B, Kreher S, Anagnostopoulos I, Johrens K, Monteleone G, Jundt F et al. Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood 2008; 112: 3339-3347.
    • (2008) Blood , vol.112 , pp. 3339-3347
    • Lamprecht, B.1    Kreher, S.2    Anagnostopoulos, I.3    Johrens, K.4    Monteleone, G.5    Jundt, F.6
  • 7
    • 77951881004 scopus 로고    scopus 로고
    • Enrichment of CCR6+Foxp3+ regulatory T cells in the tumor mass correlates with impaired CD8+ T cell function and poor prognosis of breast cancer
    • Xu L, Xu W, Qiu S, Xiong S. Enrichment of CCR6+Foxp3+ regulatory T cells in the tumor mass correlates with impaired CD8+ T cell function and poor prognosis of breast cancer. Clin Immunol 2010; 135: 466-475.
    • (2010) Clin Immunol , vol.135 , pp. 466-475
    • Xu, L.1    Xu, W.2    Qiu, S.3    Xiong, S.4
  • 8
    • 79957815661 scopus 로고    scopus 로고
    • In situ prior proliferation of CD4+ CCR6+ regulatory T cells facilitated by TGF-secreting DCs is crucial for their enrichment and suppression in tumor immunity
    • Xu L, Xu W, Wen Z, Xiong S. In situ prior proliferation of CD4+ CCR6+ regulatory T cells facilitated by TGF-secreting DCs is crucial for their enrichment and suppression in tumor immunity. PLoS ONE 2011; 6: e20282.
    • (2011) PLoS ONE , vol.6 , pp. e20282
    • Xu, L.1    Xu, W.2    Wen, Z.3    Xiong, S.4
  • 9
    • 84905392759 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China
    • Xu LF, Wu ZP, Chen Y, Zhu QS, Hamidi S, Navab R. MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China. PLoS ONE 2014; 9: e103698.
    • (2014) PLoS ONE , vol.9 , pp. e103698
    • Xu, L.F.1    Wu, Z.P.2    Chen, Y.3    Zhu, Q.S.4    Hamidi, S.5    Navab, R.6
  • 10
    • 84907197078 scopus 로고    scopus 로고
    • MiR-21 normalizes vascular smooth muscle proliferation and improves coronary collateral growth in metabolic syndrome
    • Hutcheson R, Chaplin J, Hutcheson B, Borthwick F, Proctor S, Gebb S et al. miR-21 normalizes vascular smooth muscle proliferation and improves coronary collateral growth in metabolic syndrome. FASEB J 2014; 28: 4088-4099.
    • (2014) FASEB J , vol.28 , pp. 4088-4099
    • Hutcheson, R.1    Chaplin, J.2    Hutcheson, B.3    Borthwick, F.4    Proctor, S.5    Gebb, S.6
  • 11
    • 84919882244 scopus 로고    scopus 로고
    • Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway
    • Echevarria-Vargas IM, Valiyeva F, Vivas-Mejia PE. Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1/c-Jun pathway. PLoS ONE 2014; 9: e97094.
    • (2014) PLoS ONE , vol.9 , pp. e97094
    • Echevarria-Vargas, I.M.1    Valiyeva, F.2    Vivas-Mejia, P.E.3
  • 12
    • 84891746817 scopus 로고    scopus 로고
    • The microRNA-21/PTEN pathway regulates the sensitivity of HER2-positive gastric cancer cells to trastuzumab
    • Eto K, Iwatsuki M, Watanabe M, Ida S, Ishimoto T, Iwagami S et al. The microRNA-21/PTEN pathway regulates the sensitivity of HER2-positive gastric cancer cells to trastuzumab. Ann Surg Oncol 2014; 21: 343-350.
    • (2014) Ann Surg Oncol , vol.21 , pp. 343-350
    • Eto, K.1    Iwatsuki, M.2    Watanabe, M.3    Ida, S.4    Ishimoto, T.5    Iwagami, S.6
  • 13
    • 84885035826 scopus 로고    scopus 로고
    • Dual role of miR-21 in CD4+ T-cells: Activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells
    • Smigielska-Czepiel K, van den Berg A, Jellema P, Slezak-Prochazka I, Maat H, van den Bos H et al. Dual role of miR-21 in CD4+ T-cells: activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells. PLoS ONE 2013; 8: e76217.
    • (2013) PLoS ONE , vol.8 , pp. e76217
    • Smigielska-Czepiel, K.1    Van Den Berg, A.2    Jellema, P.3    Slezak-Prochazka, I.4    Maat, H.5    Van Den Bos, H.6
  • 17
    • 84880819629 scopus 로고    scopus 로고
    • MicroRNA-17~ 92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections
    • Khan AA, Penny LA, Yuzefpolskiy Y, Sarkar S, Kalia V. MicroRNA-17~ 92 regulates effector and memory CD8 T-cell fates by modulating proliferation in response to infections. Blood 2013; 121: 4473-4483.
    • (2013) Blood , vol.121 , pp. 4473-4483
    • Khan, A.A.1    Penny, L.A.2    Yuzefpolskiy, Y.3    Sarkar, S.4    Kalia, V.5
  • 18
    • 84865160657 scopus 로고    scopus 로고
    • HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCR-selected mouse thymocytes
    • Wong GW, Knowles GC, Mak TW, Ferrando AA, Zuniga-Pflucker JC. HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCR-selected mouse thymocytes. Blood 2012; 120: 1439-1448.
    • (2012) Blood , vol.120 , pp. 1439-1448
    • Wong, G.W.1    Knowles, G.C.2    Mak, T.W.3    Ferrando, A.A.4    Zuniga-Pflucker, J.C.5
  • 19
    • 84897978329 scopus 로고    scopus 로고
    • Hepatitis B virus induces cell proliferation via HBx-induced microRNA-21 in hepatocellular carcinoma by targeting programmed cell death protein4 (PDCD4) and phosphatase and tensin homologue (PTEN)
    • Damania P, Sen B, Dar SB, Kumar S, Kumari A, Gupta E et al. Hepatitis B virus induces cell proliferation via HBx-induced microRNA-21 in hepatocellular carcinoma by targeting programmed cell death protein4 (PDCD4) and phosphatase and tensin homologue (PTEN). PLoS ONE 2014; 9: e91745.
    • (2014) PLoS ONE , vol.9 , pp. e91745
    • Damania, P.1    Sen, B.2    Dar, S.B.3    Kumar, S.4    Kumari, A.5    Gupta, E.6
  • 20
    • 44649189089 scopus 로고    scopus 로고
    • Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery
    • Ito T, Hanabuchi S, Wang YH, Park WR, Arima K, Bover L et al. Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity 2008; 28: 870-880.
    • (2008) Immunity , vol.28 , pp. 870-880
    • Ito, T.1    Hanabuchi, S.2    Wang, Y.H.3    Park, W.R.4    Arima, K.5    Bover, L.6
  • 21
    • 39149118909 scopus 로고    scopus 로고
    • Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs
    • Tosello V, Odunsi K, Souleimanian NE, Lele S, Shrikant P, Old LJ et al. Differential expression of CCR7 defines two distinct subsets of human memory CD4+CD25+ Tregs. Clin Immunol 2008; 126: 291-302.
    • (2008) Clin Immunol , vol.126 , pp. 291-302
    • Tosello, V.1    Odunsi, K.2    Souleimanian, N.E.3    Lele, S.4    Shrikant, P.5    Old, L.J.6
  • 22
    • 84872865452 scopus 로고    scopus 로고
    • The ex vivo induction of human CD103+ CD25hi Foxp3+ CD4+ and CD8+ Tregs is IL-2 and TGF-1 dependent
    • Gunnlaugsdottir B, Maggadottir SM, Skaftadottir I, Ludviksson BR. The ex vivo induction of human CD103+ CD25hi Foxp3+ CD4+ and CD8+ Tregs is IL-2 and TGF-1 dependent. Scand J Immunol 2013; 77: 125-134.
    • (2013) Scand J Immunol , vol.77 , pp. 125-134
    • Gunnlaugsdottir, B.1    Maggadottir, S.M.2    Skaftadottir, I.3    Ludviksson, B.R.4
  • 24
    • 64849100152 scopus 로고    scopus 로고
    • Cutting edge: The Foxp3 target miR-155 contributes to the development of regulatory T cells
    • Kohlhaas S, Garden OA, Scudamore C, Turner M, Okkenhaug K, Vigorito E. Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol 2009; 182: 2578-2582.
    • (2009) J Immunol , vol.182 , pp. 2578-2582
    • Kohlhaas, S.1    Garden, O.A.2    Scudamore, C.3    Turner, M.4    Okkenhaug, K.5    Vigorito, E.6
  • 25
    • 84874361847 scopus 로고    scopus 로고
    • MicroRNA-126 regulates the induction and function of CD4(+) Foxp3(+) regulatory T cells through PI3K/AKT pathway
    • Qin A, Wen Z, Zhou Y, Li Y, Li Y, Luo J et al. MicroRNA-126 regulates the induction and function of CD4(+) Foxp3(+) regulatory T cells through PI3K/AKT pathway. J Cell Mol Med 2013; 17: 252-264.
    • (2013) J Cell Mol Med , vol.17 , pp. 252-264
    • Qin, A.1    Wen, Z.2    Zhou, Y.3    Li, Y.4    Li, Y.5    Luo, J.6
  • 26
    • 84876193498 scopus 로고    scopus 로고
    • Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance
    • Sethi A, Kulkarni N, Sonar S, Lal G. Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance. Front Genet 2013; 4: 8.
    • (2013) Front Genet , vol.4 , pp. 8
    • Sethi, A.1    Kulkarni, N.2    Sonar, S.3    Lal, G.4
  • 27
    • 84892502529 scopus 로고    scopus 로고
    • CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets
    • Smigiel KS, Richards E, Srivastava S, Thomas KR, Dudda JC, Klonowski KD et al. CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets. J Exp Med 2014; 211: 121.
    • (2014) J Exp Med , vol.211 , pp. 121
    • Smigiel, K.S.1    Richards, E.2    Srivastava, S.3    Thomas, K.R.4    Dudda, J.C.5    Klonowski, K.D.6
  • 28
    • 84866018690 scopus 로고    scopus 로고
    • TGF-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma
    • Yang P, Li QJ, Feng Y, Zhang Y, Markowitz GJ, Ning S et al. TGF-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma. Cancer Cell 2012; 22: 291-303.
    • (2012) Cancer Cell , vol.22 , pp. 291-303
    • Yang, P.1    Li, Q.J.2    Feng, Y.3    Zhang, Y.4    Markowitz, G.J.5    Ning, S.6
  • 29
    • 84907999496 scopus 로고    scopus 로고
    • MicroRNAs expression profile in CCR6 (+) regulatory T cells
    • Zhao J, Li Y, Hu Y, Chen C, Zhou Y, Tao Y et al. MicroRNAs expression profile in CCR6 (+) regulatory T cells. PeerJ 2014; 2: e575.
    • (2014) Peer J , vol.2 , pp. e575
    • Zhao, J.1    Li, Y.2    Hu, Y.3    Chen, C.4    Zhou, Y.5    Tao, Y.6
  • 30
    • 84893702351 scopus 로고    scopus 로고
    • MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN
    • Yan NB, Zhao YY, Li XL, Yong Z. MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN. Biochem Biophys Res Commun 2014; 443: 802-807.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 802-807
    • Yan, N.B.1    Zhao, Y.Y.2    Li, X.L.3    Yong, Z.4
  • 31
    • 84881422322 scopus 로고    scopus 로고
    • Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction
    • Locke FL, Zha YY, Zheng Y, Driessens G, Gajewski TF. Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction. J Immunol 2013; 191: 1677-1685.
    • (2013) J Immunol , vol.191 , pp. 1677-1685
    • Locke, F.L.1    Zha, Y.Y.2    Zheng, Y.3    Driessens, G.4    Gajewski, T.F.5
  • 32
    • 77953624215 scopus 로고    scopus 로고
    • MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
    • Pan W, Zhu S, Yuan M, Cui H, Wang L, Luo X et al. MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1. J Immunol 2010; 184: 6773-6781.
    • (2010) J Immunol , vol.184 , pp. 6773-6781
    • Pan, W.1    Zhu, S.2    Yuan, M.3    Cui, H.4    Wang, L.5    Luo, X.6
  • 34
    • 84902528910 scopus 로고    scopus 로고
    • MIR-21 overexpression enhances TGF-1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy
    • Wang JY, Gao YB, Zhang N, Zou DW, Wang P, Zhu ZY et al. miR-21 overexpression enhances TGF-1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy. Mol Cell Endocrinol 2014; 392: 163-172.
    • (2014) Mol Cell Endocrinol , vol.392 , pp. 163-172
    • Wang, J.Y.1    Gao, Y.B.2    Zhang, N.3    Zou, D.W.4    Wang, P.5    Zhu, Z.Y.6
  • 35
    • 84906076816 scopus 로고    scopus 로고
    • The role of TGF-1-miR-21-ROS pathway in bystander responses induced by irradiated non-small-cell lung cancer cells
    • Jiang Y, Chen X, Tian W, Yin X, Wang J, Yang H. The role of TGF-1-miR-21-ROS pathway in bystander responses induced by irradiated non-small-cell lung cancer cells. Br J Cancer 2014; 111: 772-780.
    • (2014) Br J Cancer , vol.111 , pp. 772-780
    • Jiang, Y.1    Chen, X.2    Tian, W.3    Yin, X.4    Wang, J.5    Yang, H.6
  • 36
    • 84886947397 scopus 로고    scopus 로고
    • Transcriptional control of regulatory T cell development and function
    • Luo CT, Li MO. Transcriptional control of regulatory T cell development and function. Trends Immunol 2013; 34: 531-539.
    • (2013) Trends Immunol , vol.34 , pp. 531-539
    • Luo, C.T.1    Li, M.O.2
  • 37
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012; 30: 531-564.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 38
    • 67649528173 scopus 로고    scopus 로고
    • Human natural Treg microRNA signature: Role of microRNA-31 and microRNA-21 in FOXP3 expression
    • Rouas R, Fayyad-Kazan H, El Zein N, Lewalle P, Rothe F, Simion A et al. Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression. Eur J Immunol 2009; 39: 1608-1618.
    • (2009) Eur J Immunol , vol.39 , pp. 1608-1618
    • Rouas, R.1    Fayyad-Kazan, H.2    El Zein, N.3    Lewalle, P.4    Rothe, F.5    Simion, A.6
  • 39
    • 79956097598 scopus 로고    scopus 로고
    • Expansion of CD4(+)CD25 (+) regulatory T cells from cord blood CD4(+) cells using the common-chain cytokines (IL-2 and IL-15) and rapamycin
    • Asanuma S, Tanaka J, Sugita J, Kosugi M, Shiratori S, Wakasa K et al. Expansion of CD4(+)CD25 (+) regulatory T cells from cord blood CD4(+) cells using the common-chain cytokines (IL-2 and IL-15) and rapamycin. Ann Hematol 2011; 90: 617-624.
    • (2011) Ann Hematol , vol.90 , pp. 617-624
    • Asanuma, S.1    Tanaka, J.2    Sugita, J.3    Kosugi, M.4    Shiratori, S.5    Wakasa, K.6
  • 40
    • 38049177784 scopus 로고    scopus 로고
    • Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3 + regulatory T cells compared with conventional CD4+ T cells
    • Zeiser R, Leveson-Gower DB, Zambricki EA, Kambham N, Beilhack A, Loh J et al. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3 + regulatory T cells compared with conventional CD4+ T cells. Blood 2008; 111: 453-462.
    • (2008) Blood , vol.111 , pp. 453-462
    • Zeiser, R.1    Leveson-Gower, D.B.2    Zambricki, E.A.3    Kambham, N.4    Beilhack, A.5    Loh, J.6


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