-
2
-
-
73149115341
-
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
-
Johnston S, Pippen J Jr, Pivot X, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009;27:5538-5546.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5538-5546
-
-
Johnston, S.1
Pippen, J.2
Pivot, X.3
-
3
-
-
62449323761
-
A novel proximity assay for the detection of proteins and protein complexes: Quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffin-embedded cell lines and breast cancer tissue
-
Shi Y, Huang W, Tan Y, et al. A novel proximity assay for the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffin-embedded cell lines and breast cancer tissue. Diagn Mol Pathol 2009;18:11-21.
-
(2009)
Diagn Mol Pathol
, vol.18
, pp. 11-21
-
-
Shi, Y.1
Huang, W.2
Tan, Y.3
-
4
-
-
77955763771
-
Analytical validation of a highly quantitative, sensitive, accurate, and reproducible assay (HERmark) for the measurement of HER2 total protein and HER2 homodimers in FFPE breast cancer tumor specimens
-
Larson JS, Goodman LJ, Tan Y, et al. Analytical validation of a highly quantitative, sensitive, accurate, and reproducible assay (HERmark) for the measurement of HER2 total protein and HER2 homodimers in FFPE breast cancer tumor specimens. Patholog Res Int 2010;2010:814176.
-
(2010)
Patholog Res Int
, vol.2010
, pp. 814176
-
-
Larson, J.S.1
Goodman, L.J.2
Tan, Y.3
-
5
-
-
77955597966
-
Comparison of central HER2 testing with quantitative total HER2 expression and HER2 homodimer measurements using a novel proximity-based assay
-
Huang W, Reinholz M, Weidler J, et al. Comparison of central HER2 testing with quantitative total HER2 expression and HER2 homodimer measurements using a novel proximity-based assay. Am J Clin Pathol 2010;134:303-311.
-
(2010)
Am J Clin Pathol
, vol.134
, pp. 303-311
-
-
Huang, W.1
Reinholz, M.2
Weidler, J.3
-
6
-
-
78449281431
-
Quantitative HER2 protein levels predict outcome in fluorescence in situ hybridization-positive patients with metastatic breast cancer treated with trastuzumab
-
Lipton A, Kostler WJ, Leitzel K, et al. Quantitative HER2 protein levels predict outcome in fluorescence in situ hybridization-positive patients with metastatic breast cancer treated with trastuzumab. Cancer 2010;116:5168-5178.
-
(2010)
Cancer
, vol.116
, pp. 5168-5178
-
-
Lipton, A.1
Kostler, W.J.2
Leitzel, K.3
-
7
-
-
0029814271
-
A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
-
Tzahar E, Waterman H, Chen X, et al. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 1996;16:5276-5287.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5276-5287
-
-
Tzahar, E.1
Waterman, H.2
Chen, X.3
-
8
-
-
2142843806
-
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
-
Pinkas-Kramarski R, Soussan L, Waterman H, et al. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J 1996;15:2452-2467.
-
(1996)
EMBO J
, vol.15
, pp. 2452-2467
-
-
Pinkas-Kramarski, R.1
Soussan, L.2
Waterman, H.3
-
9
-
-
0034115478
-
Blocking HER-2/HER-3 function with a dominant negative form of HER-3 in cells stimulated by heregulin and in breast cancer cells with HER-2 gene amplification
-
Ram TG, Schelling ME, Hosick HL. Blocking HER-2/HER-3 function with a dominant negative form of HER-3 in cells stimulated by heregulin and in breast cancer cells with HER-2 gene amplification. Cell Growth Differ 2000;11:173-183.
-
(2000)
Cell Growth Differ
, vol.11
, pp. 173-183
-
-
Ram, T.G.1
Schelling, M.E.2
Hosick, H.L.3
-
10
-
-
0042307325
-
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation
-
Holbro T, Beerli RR, Maurer F, et al. The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A 2003;100:8933-8938.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8933-8938
-
-
Holbro, T.1
Beerli, R.R.2
Maurer, F.3
-
11
-
-
48649092620
-
A central role for HER3 in HER2-amplified breast cancer: Implications for targeted therapy
-
Lee-Hoeflich S T, Crocker L, Yao E, et al. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res 2008;68:5878-5887.
-
(2008)
Cancer Res
, vol.68
, pp. 5878-5887
-
-
Lee-Hoeflich, S.T.1
Crocker, L.2
Yao, E.3
-
12
-
-
84884279586
-
HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer
-
Lipton A, Goodman L, Leitzel K, et al. HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer. Breast Cancer Res Treat 2013;141:43-53.
-
(2013)
Breast Cancer Res Treat
, vol.141
, pp. 43-53
-
-
Lipton, A.1
Goodman, L.2
Leitzel, K.3
-
13
-
-
79551527609
-
Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins
-
Mukherjee A, Badal Y, Nguyen XT, et al. Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins. PLoS One 2011;6:e16443.
-
(2011)
PLoS One
, vol.6
, pp. e16443
-
-
Mukherjee, A.1
Badal, Y.2
Nguyen, X.T.3
-
14
-
-
84941778726
-
Profiling HER3/ErbB3 activation in formalin-fixed, paraffin-embedded (FFPE) breast tumor samples that expresss high and low HER2/ErbB2 levels using proximitybased immunoassays. [abstract]
-
3029
-
Wallweber J, Chenna A, Ravanera R, et al. Profiling HER3/ErbB3 activation in formalin-fixed, paraffin-embedded (FFPE) breast tumor samples that expresss high and low HER2/ErbB2 levels using proximitybased immunoassays. [abstract]. Cancer Res 2013;73:Abstract 3029.
-
(2013)
Cancer Res
, vol.73
-
-
Wallweber, J.1
Chenna, A.2
Ravanera, R.3
-
15
-
-
1842605531
-
Insights into ERBB signaling from the structure of the ERBB2-pertuzumab complex
-
Franklin MC, Carey KD, Vajdos F F, et al. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 2004;5:317-328.
-
(2004)
Cancer Cell
, vol.5
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
-
16
-
-
84861576201
-
The landscape of cancer genes and mutational processes in breast cancer
-
Stephens PJ, Tarpey PS, Davies H, et al. The landscape of cancer genes and mutational processes in breast cancer. Nature 2012;486:400-404.
-
(2012)
Nature
, vol.486
, pp. 400-404
-
-
Stephens, P.J.1
Tarpey, P.S.2
Davies, H.3
-
17
-
-
84862526929
-
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
-
Shah SP, Roth A, Goya R, et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 2012;486:395-399.
-
(2012)
Nature
, vol.486
, pp. 395-399
-
-
Shah, S.P.1
Roth, A.2
Goya, R.3
-
18
-
-
77955660663
-
Diverse somatic mutation patterns and pathway alterations in human cancers
-
Kan Z, Jaiswal BS, Stinson J, et al. Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 2010;466:869-873.
-
(2010)
Nature
, vol.466
, pp. 869-873
-
-
Kan, Z.1
Jaiswal, B.S.2
Stinson, J.3
-
19
-
-
84862584058
-
Whole-genome analysis informs breast cancer response to aromatase inhibition
-
Ellis MJ, Ding L, Shen D, et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature 2012;486:353-360.
-
(2012)
Nature
, vol.486
, pp. 353-360
-
-
Ellis, M.J.1
Ding, L.2
Shen, D.3
-
20
-
-
84877028141
-
Comprehensive molecular portraits of human breast tumours
-
Cancer Genome Atlas Research Network. Comprehensive molecular portraits of human breast tumours. Nature 2012;490:61-70.
-
(2012)
Nature
, vol.490
, pp. 61-70
-
-
Cancer Genome Atlas Research Network1
-
21
-
-
31544449750
-
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas
-
Lee JW, Soung YH, Seo SH, et al. Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas. Clin Cancer Res 2006;12:57-61.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 57-61
-
-
Lee, J.W.1
Soung, Y.H.2
Seo, S.H.3
-
22
-
-
70349969478
-
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution
-
Shah S P, Morin RD, Khattra J, et al. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 2009;461:809-813.
-
(2009)
Nature
, vol.461
, pp. 809-813
-
-
Shah, S.P.1
Morin, R.D.2
Khattra, J.3
-
23
-
-
84862523863
-
Sequence analysis of mutations and translocations across breast cancer subtypes
-
Banerji S, Cibulskis K, Rangel-Escareno C, et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 2012;486:405-409.
-
(2012)
Nature
, vol.486
, pp. 405-409
-
-
Banerji, S.1
Cibulskis, K.2
Rangel-Escareno, C.3
-
24
-
-
84873918443
-
Activating HER2 mutations in HER2 gene amplification negative breast cancer
-
Bose R, Kavuri SM, Searleman AC, et al. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discov 2013;3:224-237.
-
(2013)
Cancer Discov
, vol.3
, pp. 224-237
-
-
Bose, R.1
Kavuri, S.M.2
Searleman, A.C.3
-
25
-
-
80055032877
-
Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
-
Kancha RK, von Bubnoff N, Bartosch N, et al. Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. PLoS One 2011;6:e26760.
-
(2011)
PLoS One
, vol.6
, pp. e26760
-
-
Kancha, R.K.1
Von Bubnoff, N.2
Bartosch, N.3
-
26
-
-
84865994665
-
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
-
Greulich H, Kaplan B, Mertins P, et al. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A 2012;109:14476-14481.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 14476-14481
-
-
Greulich, H.1
Kaplan, B.2
Mertins, P.3
-
27
-
-
79959838081
-
Integrated genomic analyses of ovarian carcinoma
-
Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 2011;474:609-615.
-
(2011)
Nature
, vol.474
, pp. 609-615
-
-
Cancer Genome Atlas Research Network1
-
28
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
Barretina J, Caponigro G, Stransky N, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012;483:603-607.
-
(2012)
Nature
, vol.483
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
|