Activation of mTOR signaling mediates the increased expression of AChE in high glucose condition: in vitro and in vivo evidences

Molecular Neurobiology

Volumn 53, Issue 7, 2016, Pages 4972-4980

  Liu, Yao Wu ^a   Zhang, Liang ^a,b   Li, Yu ^a   Cheng, Ya Qin ^a   Zhu, Xia ^a   Zhang, Fan ^a   Yin, Xiao Xing ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b the People s Hospital of Hebi   (China)

Author keywords

Acetylcholinesterase; High glucose; Mammalian target of rapamycin; Oxidative stress; PI3K Akt pathway

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCHOLINESTERASE; ACETYLCYSTEINE; GLUCOSE; MALONALDEHYDE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; S6 KINASE; SUPEROXIDE DISMUTASE; CHROMONE DERIVATIVE; LY 290042; MORPHOLINE DERIVATIVE; MTOR PROTEIN, RAT; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OSMOTIC PRESSURE; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TRANSFORMED CELL LINE; WISTAR RAT;

ACETYLCHOLINESTERASE; ANIMALS; CELL LINE, TRANSFORMED; CELLS, CULTURED; CEREBRAL CORTEX; CHROMONES; DIABETES MELLITUS, EXPERIMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; HIPPOCAMPUS; MALE; MICE; MORPHOLINES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84941686806     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9425-6     Document Type: Article

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