Oral administration of P. gingivalis induces dysbiosis of gut microbiota and impaired barrier function leading to dissemination of enterobacteria to the liver

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Nakajima, Mayuka ^a   Arimatsu, Kei ^a   Kato, Tamotsu ^b   Matsuda, Yumi ^a   Minagawa, Takayoshi ^a   Takahashi, Naoki ^a   Ohno, Hiroshi ^b,c   Yamazaki, Kazuhisa ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; ENDOTOXIN; OCCLUDIN; PROTEIN ZO1; RNA 16S; AUTACOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIUM CULTURE; BACTERIUM DETECTION; BACTEROIDETES; C57BL 6 MOUSE; CONTROLLED STUDY; DNA EXTRACTION; DOWN REGULATION; DYSBIOSIS; ENTEROBACTERIACEAE; FIRMICUTES; GENE EXPRESSION; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; LIVER; MALE; MICROBIAL COMMUNITY; MICROBIAL DIVERSITY; MOUSE; NONHUMAN; OCCLUDIN GENE; PHYLOGENY; POLYMERASE CHAIN REACTION; PORPHYROMONAS GINGIVALIS; PYROSEQUENCING; TJP 1 GENE; ANIMAL; BACTEROIDACEAE INFECTION; C57BL MOUSE; COMPLICATION; ENDOTOXEMIA; ENTEROBACTERIACEAE INFECTIONS; FECES; HUMAN; INFLAMMATION; METABOLISM; MICROBIOLOGY; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHYSIOLOGY;

ADMINISTRATION, ORAL; ANIMALS; BACTEROIDACEAE INFECTIONS; DYSBIOSIS; ENDOTOXEMIA; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; FECES; GASTROINTESTINAL MICROBIOME; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LIVER; MALE; MICE; MICE, INBRED C57BL; PORPHYROMONAS GINGIVALIS; RNA, RIBOSOMAL, 16S;

EID: 84941662532     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0134234     Document Type: Article

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