Gut microbiota affects sensitivity to acute DSS-induced colitis independently of host genotype

Inflammatory Bowel Diseases

Volumn 19, Issue 12, 2013, Pages 2560-2567

  Brinkman, Brigitta M ^a   Becker, Anne ^b   Ayiseh, Rene B ^a   Hildebrand, Falk ^c,d   Raes, Jeroen ^c,d   Huys, Geert ^a,b   Vandenabeele, Peter ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Caspase; Cohousing; Colitis; DGGE; DSS; Gut microbiota; Knockout

Indexed keywords

CASPASE 11; CASPASE 3; DEXTRAN SULFATE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 33; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; RNA 16S;

AMPLICON; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENATURING GRADIENT GEL ELECTROPHORESIS; DISEASE ACTIVITY SCORE; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES MICROFLORA; FEMALE; GENE MUTATION; GENE SEQUENCE; GENOTYPE; HOST; INTESTINE FLORA; MICROBIAL COMMUNITY; MICROBIOME; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHENOTYPE; PREVOTELLA; PRIORITY JOURNAL; PROGENY; REAL TIME POLYMERASE CHAIN REACTION; WEIGHT REDUCTION;

ACUTE DISEASE; ANIMALS; CASPASE 3; CELL PROLIFERATION; COLITIS; CYTOKINES; DEXTRAN SULFATE; FECES; FEMALE; FLOW CYTOMETRY; GASTROINTESTINAL TRACT; HOST-PATHOGEN INTERACTIONS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROBIOTA; PEROXIDASE; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84888310137     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e3182a8759a     Document Type: Article

References (43)

1. Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444: 1027-1031.
2. Hammer HF. Gut microbiota and inflammatory bowel disease. Dig Dis. 2011;29:550-553.
3. Boerner BP, Sarvetnick NE. Type 1 diabetes: role of intestinal microbiome in humans and mice. Ann N Y Acad Sci. 2011;1243:103-118.
4. Clemente JC, Ursell LK, Parfrey LW, et al. The impact of the gut microbiota on human health: an integrative view. Cell. 2012;148:1258-1270.
5. Faith JJ, Rey FE, O'Donnell D, et al. Creating and characterizing communities of human gut microbes in gnotobiotic mice. ISME J. 2010;4: 1094-1098.
6. Gootenberg DB, Turnbaugh PJ. Companion animals symposium: humanized animal models of the microbiome. J Anim Sci. 2011;89:1531-1537.
7. Brinkman BM, Hildebrand F, Kubica M, et al. Caspase deficiency alters the murine gut microbiome. Cell Death Dis. 2011;2:e220.
8. Rehman A, Sina C, Gavrilova O, et al. Nod2 is essential for temporal development of intestinal microbial communities. Gut. 2011;60:1354-1362.
9. Elinav E, Strowig T, Kau AL, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011;145:745-757.
10. Henao-Mejia J, Elinav E, Jin C, et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature. 2012;482:179-185.
11. Stecher B, Chaffron S, Kappeli R, et al. Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria. PLoS Pathog. 2010;6:e1000711.
12. Berer K, Mues M, Koutrolos M, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature. 2011;479:538-541.
13. Vijay-Kumar M, Aitken JD, Carvalho FA, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science. 2010; 328:228-231.
14. Lahat G, Halperin D, Barazovsky E, et al. Immunomodulatory effects of ciprofloxacin in TNBS-induced colitis in mice. Inflamm Bowel Dis. 2007; 13:557-565.
15. Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology. 2004;126:1620-1633.
16. Wlodarska M, Willing B, Keeney KM, et al. Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis. Infect Immun. 2011;79:1536-1545.
17. Lodes MJ, Cong Y, Elson CO, et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest. 2004;113:1296-1306.
18. Nell S, Suerbaum S, Josenhans C. The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models. Nat Rev Microbiol. 2010;8:564-577.
19. Bloom SM, Bijanki VN, Nava GM, et al. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe. 2011;9:390-403.
20. Claes IJ, De Keersmaecker SC, Vanderleyden J, et al. Lessons from probiotic-host interaction studies in murine models of experimental colitis. Mol Nutr Food Res. 2011;55:1441-1453.
21. Woo M, Hakem R, Soengas MS, et al. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 1998;12:806-819.
22. Vanden Berghe T, Goethals A, Demon D, et al. An inactivating caspase-11 passenger mutation muddles sepsis research. Am J Resp Crit Care Med. 2013;188:120-121.
23. Bradley PP, Priebat DA, Christensen RD, et al. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78:206-209.
24. Zoetendal EG, Heilig HG, Klaassens ES, et al. Isolation of DNA from bacterial samples of the human gastrointestinal tract. Nat Protoc. 2006;1: 870-873.
25. Vanhoutte T, Huys G, Brandt E, et al. Temporal stability analysis of the microbiota in human feces by denaturing gradient gel electrophoresis using universal and group-specific 16S rRNA gene primers. FEMS Microbiol Ecol. 2004;48:437-446.
26. Temmerman R, Scheirlinck I, Huys G, et al. Culture-independent analysis of probiotic products by denaturing gradient gel electrophoresis. Appl Environ Microbiol. 2003;69:220-226.
27. Fierer N, Jackson JA, Vilgalys R, et al. Assessment of soil microbial community structure by use of taxon-specific quantitative PCR assays. Appl Environ Microbiol. 2005;71:4117-4120.
28. Dalwai F, Spratt DA, Pratten J. Use of quantitative PCR and culture methods to characterize ecological flux in bacterial biofilms. J Clin Microbiol. 2007;45:3072-3076.
29. Anderson MJ. Distance-based tests for homogeneity of multivariate dispersions. Biometrics. 2006;62:245-253.
30. Huys G, Vanhoutte T, Vandamme P. Application of sequence-dependent electrophoresis fingerprinting in exploring biodiversity and population dynamics of human intestinal microbiota: what can be revealed? Interdiscip Perspect Infect Dis. 2008;2008:597603.
31. Bamias G, Kaltsa G, Ladas SD. Cytokines in the pathogenesis of ulcerative colitis. Discov Med. 2011;11:459-467.
32. van Deventer SJ. Review article: chemokine production by intestinal epithelial cells: a therapeutic target in inflammatory bowel disease? Aliment Pharmacol Ther. 1997;11(suppl 3):116-120.
33. Beltran CJ, Nunez LE, Diaz-Jimenez D, et al. Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2010;16:1097-1107.
34. Lucke K, Miehlke S, Jacobs E, et al. Prevalence of Bacteroides and Prevotella spp. in ulcerative colitis. J Med Microbiol. 2006;55:617-624.
35. Heimesaat MM, Nogai A, Bereswill S, et al. MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut. 2010;59:1079-1087.
36. De Palma G, Nadal I, Medina M, et al. Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children. BMC Microbiol. 2010;10:63.
37. Sobhani I, Tap J, Roudot-Thoraval F, et al. Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS One. 2011;6:e16393.
38. Wright DP, Rosendale DI, Robertson AM. Prevotella enzymes involved in mucin oligosaccharide degradation and evidence for a small operon of genes expressed during growth on mucin. FEMS Microbiol Lett. 2000; 190:73-79.
39. Tsai HH, Dwarakanath AD, Hart CA, et al. Increased faecal mucin sulphatase activity in ulcerative colitis: a potential target for treatment. Gut. 1995;36:570-576.
40. Campbell JH, Foster CM, Vishnivetskaya T, et al. Host genetic and environmental effects on mouse intestinal microbiota. ISME J. 2012;6: 2033-2044.
41. Hildebrand F, Nguyen AT, Brinkman B, et al. Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice. Genome Biol. 2013;14:R4.
42. Friswell MK, Gika H, Stratford IJ, et al. Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice. PLoS One. 2010;5:e8584.
43. Hufeldt MR, Nielsen DS, Vogensen FK, et al. Variation in the gut microbiota of laboratory mice is related to both genetic and environmental factors. Comp Med. 2010;60:336-347.