Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/ß-catenin pathway

Carcinogenesis

Volumn 36, Issue 6, 2015, Pages 622-631

  Sakamaki, Akira ^a   Katsuragi, Yoshinori ^a   Otsuka, Kensuke ^b   Tomita, Masanori ^b   Obata, Miki ^a   Iwasaki, Tomohiro ^a   Abe, Manabu ^c   Sato, Toshihiro ^a   Ochiai, Masako ^d   Sakuraba, Yoshiyuki ^e   Aoyagi, Yutaka ^a   Gondo, Yoichi ^e   Sakimura, Kenji ^c   Nakagama, Hitoshi ^d   Mishima, Yukio ^a   Kominami, Ryo ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b CENTRAL RESEARCH INSTITUTE OF ELECTRIC POWER INDUSTRY   (Japan)

^c NIIGATA UNIVERSITY   (Japan)

^d NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^e RIKEN YOKOHAMA INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; MYC PROTEIN; PROTEIN; PROTEIN BCL 11B; PROTEIN SWI; TRANSCRIPTION FACTOR SNF; UNCLASSIFIED DRUG; WNT PROTEIN; BCL11B PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; LGR5 PROTEIN, HUMAN; MYC PROTEIN, HUMAN; NONHISTONE PROTEIN; REPRESSOR PROTEIN; SWI-SNF-B CHROMATIN-REMODELING COMPLEX; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ADENOMA; ALLELE; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; COLON CANCER; CONTROLLED STUDY; CRYPT CELL; DOWN REGULATION; GAMMA IRRADIATION; GENE MUTATION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; INTESTINE TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; REGENERATION; STEM CELL; WNT SIGNALING PATHWAY; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CACO 2 CELL LINE; CELL PROLIFERATION; CELL TRANSFORMATION; CLASSIFICATION; COLON TUMOR; GENETICS; HCT116 CELL LINE; HEK293 CELL LINE; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; RADIATION RESPONSE; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CELL LINE;

ADENOMA; ANIMALS; BETA CATENIN; CACO-2 CELLS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL PROTEINS, NON-HISTONE; COLONIC NEOPLASMS; CYCLIN D1; HCT116 CELLS; HEK293 CELLS; HUMANS; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-MYC; RECEPTORS, G-PROTEIN-COUPLED; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84941653201     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgv044     Document Type: Article

References (51)

1. Wilson, B.G. et al. (2011) SWI/SNF nucleosome remodellers and cancer. Nat. Rev. Cancer 11, 481-492.
2. Wang, X. et al. (2014) Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer-mechanisms and potential therapeutic insights. Clin. Cancer Res., 20, 21-27.
3. Hargreaves, D.C. et al. (2011) ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res., 21, 396-420.
4. Holstege, F.C. et al. (1998) Dissecting the regulatory circuitry of a eukaryotic genome. Cell, 95, 717-728.
5. Polakis, P. (2000) Wnt signaling and cancer. Genes Dev., 14, 1837-1851.
6. Clevers, H. (2006) Wnt/beta-catenin signaling in development and disease. Cell, 127, 469-480.
7. Mann, B. et al. (1999) Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc. Natl Acad. Sci. USA., 96, 1603-1608.
8. Herbst, A. et al. (2014) Comprehensive analysis of ß-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/ß-catenin signaling. BMC Genomics, 15, 74.
9. Kinzler, K.W. et al. (1996) Lessons from hereditary colorectal cancer. Cell, 87, 159-170.
10. Ilyas, M. et al. (1999) Genetic pathways in colorectal and other cancers. Eur. J. Cancer, 35, 1986-2002.
11. Moser, A.R. et al. (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science, 247, 322-324.
12. Barker, N. et al. (2009) Crypt stem cells as the cells-of-origin of intestinal cancer. Nature, 457, 608-611.
13. Barker, N. et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 449, 1003-1007.
14. Barker, N. et al. (2001) The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. EMBO J., 20, 4935-4943.
15. Mora-Blanco, E.L. et al. (2014) Activation of ß-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene, 33, 933-938.
16. Liu, P. et al. (2010) Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity. Immunol. Rev., 238, 138-149.
17. Kominami, R. (2012) Role of the transcription factor Bcl11b in development and lymphomagenesis. Proc. Jpn. Acad. Ser. B. Phys. Biol. Sci., 88, 72-87.
18. Wakabayashi, Y. et al. (2003) Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat. Immunol., 4, 533-539.
19. Arlotta, P. et al. (2005) Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron, 45, 207-221.
20. Golonzhka, O. et al. (2009) Dual role of COUP-TF-interacting protein 2 in epidermal homeostasis and permeability barrier formation. J. Invest Dermatol., 129, 1459-1470.
21. Katsuragi, Y. et al. (2013) Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors. Mech. Dev., 130, 482-492.
22. Kamimura, K. et al. (2007) Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development. Biochem. Biophys. Res. Commun., 355, 538-542.
23. Keersmaecker, K. et al. (2010) The TLX1 oncogene drives aneuploidy in T cell transformation. Nat. Med. 11, 1321-1327.
24. Gutierrez, A. et al. (2011) The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood, 118, 4169-4173.
25. Okazuka, K. et al. (2005) p53 prevents maturation of T cell development to the immature CD4-CD8+ stage in Bcl11b-/- mice. Biochem. Biophys. Res. Commun., 328, 545-549.
26. Kadoch, C. et al. (2013) Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat. Genet., 45, 592-601.
27. Young, J. et al. (1993) Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas. Oncogene, 8, 671-675.
28. Weber, T.K. et al. (1999) Genome-wide allelotyping indicates increased loss of heterozygosity on 9p and 14q in early age of onset colorectal cancer. Cytogenet. Cell Genet., 86, 142-147.
29. Mao, X. et al. (2006) Allele-specific loss of heterozygosity in multiple colorectal adenomas: toward an integrated molecular cytogenetic map II. Cancer Genet. Cytogenet., 167, 1-14.
30. Wood, L.D. et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science, 318, 1108-1113.
31. Go, R. et al. (2013) Cell of origin in radiation-induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele. Cancer Sci., 104, 1009-1016.
32. Moriyama, A. et al. (2007) GFP transgenic mice reveal active canonical Wnt signal in neonatal brain and in adult liver and spleen. Genesis, 45, 90-100.
33. Boivin, G.P. et al. (2003) Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology, 124, 762-777.
34. Obata, M. et al. (2012) BCL11B tumor suppressor inhibits HDM2 expression in a p53-dependent manner. Cell. Signal., 24, 1047-1052.
35. Ohi, H. et al. (2007) Multi-step lymphomagenesis deduced from DNA changes in thymic lymphomas and atrophic thymuses at various times after gamma-irradiation. Oncogene, 26, 5280-5289.
36. Clarke, A.R. (2006) Wnt signalling in the mouse intestine. Oncogene, 25, 7512-7521.
37. Taketo, M.M. et al. (2009) Mouse models of colon cancer. Gastroenterology, 136, 780-798.
38. Korinek, V. et al. (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science, 275, 1784-1787.
39. Tamura, M. et al. (2007) Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics, 89, 618-629.
40. March, H.N. et al. (2011) Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis. Nat. Genet., 43, 1202-1209.
41. Scoville, D.H. et al. (2008) Current view: intestinal stem cells and signaling. Gastroenterology, 134, 849-864.
42. Potten, C.S. et al. (2009) The stem cells of small intestinal crypts: where are they? Cell Prolif., 42, 731-750.
43. Montgomery, R.K. et al. (2011) Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc. Natl Acad. Sci. USA., 108, 179-184.
44. Yan, K.S. et al. (2012) The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. Proc. Natl Acad. Sci. USA., 109, 466-471.
45. Muñoz, J. et al. (2012) The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J., 31, 3079-3091.
46. Buczacki, S.J. et al. (2013) Intestinal label-retaining cells are secretory precursors expressing Lgr5. Nature, 495, 65-69.
47. Metcalfe, C. et al. (2014) Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell, 14, 149-159.
48. Berger, A.H. et al. (2011) A continuum model for tumour suppression. Nature, 476, 163-169.
49. Wiles, E.T. et al. (2013) BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma. PLoS One, 8, e59369.
50. Shi, J. et al. (2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev., 27, 2648-2662.
51. Helming, K.C. et al. (2014) ARID1B is a specific vulnerability in ARID1Amutant cancers. Nat. Med., 20, 251-254.